2013
Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression
Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Developmental Biology 2013, 377: 333-344. PMID: 23506836, PMCID: PMC3652235, DOI: 10.1016/j.ydbio.2013.03.008.Peer-Reviewed Original ResearchConceptsNeural crest cellsCrest cellsCraniofacial developmentNeural crestCranial neural crest cellsCore apoptotic pathwayMurine craniofacial developmentMsx gene expressionCleft secondary palateCell cycle genesCell cycle progressionEpigenomic levelsMutant embryosCraniofacial morphogenesisCycle genesCranial mesenchymeGenetic pathwaysGene expressionCycle progressionApoptotic pathwayMurine geneticsCritical regulatorHDAC3Mesodermal originSecondary palate
2011
Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle
Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle. Journal Of Biological Chemistry 2011, 286: 33301-33309. PMID: 21808063, PMCID: PMC3190900, DOI: 10.1074/jbc.m111.277707.Peer-Reviewed Original ResearchConceptsNutritional environmentProper mitochondrial functionHistone deacetylase 3Bioenergetic genesSkeletal muscleNucleosomal histonesHDAC3 geneGene expressionCovalent modificationHuman diseasesHDAC3Mitochondrial functionEmbryonic deletionCardiac mitochondriaGenesLipid metabolismDeletionMilder phenotypePhenotypeMajor cardiomyopathiesLethalityEpigenomeGenomeHistonesMouse model