2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaEmotionsFemaleHumansMagnetic Resonance ImagingMalePainReceptor, Cannabinoid, CB1Stress Disorders, Post-TraumaticYoung Adult
2023
Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Korem N, Ben-Zion Z, Spiller T, Duek O, Harpaz-Rotem I, Pietrzak R. Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 339: 89-97. PMID: 37437721, DOI: 10.1016/j.jad.2023.07.036.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalEmotionsHumansRisk FactorsStress Disorders, Post-TraumaticVeteransConceptsPosttraumatic stress disorderAvoidance copingTraumatic eventsU.S. military veteransEmotional stabilityNegative affect symptomsEmotional neglectSexual abuseAffect symptomsMilitary veteransAvoidant coping strategiesGreater emotional stabilityPhysical health outcomesPsychosocial risk factorsConsolidated memoryStress disorderCoping strategiesAdverse childhood experiencesStressful experiencesCopingVeterans StudyChildhood experiencesStrong feelingsNetwork analytic approachConscientiousnessLong term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.Peer-Reviewed Original ResearchMeSH KeywordsExtinction, PsychologicalHumansKetamineMidazolamPilot ProjectsPsychotherapyStress Disorders, Post-TraumaticConceptsKetamine recipientsSingle infusionMain study outcomeTiming of administrationEnd of treatmentNMDA receptor antagonistFunctional neural changesFrequency of administrationSignificant clinical implicationsTrauma-focused psychotherapyBrief exposure therapyAmygdala-vmPFC connectivityPost-retrieval extinctionKetamine doseKetamine administrationReceptor antagonistTrauma scriptsNeural changesClinical implicationsDecreased connectivityExposure therapyKetamineTrauma memoriesStudy outcomesUncinate fasciculus
2022
Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors
Ben-Zion Z, Korem N, Spiller TR, Duek O, Keynan JN, Admon R, Harpaz-Rotem I, Liberzon I, Shalev AY, Hendler T. Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors. Molecular Psychiatry 2022, 28: 657-667. PMID: 36280750, PMCID: PMC9918676, DOI: 10.1038/s41380-022-01842-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaBayes TheoremFemaleHippocampusHumansMagnetic Resonance ImagingStress Disorders, Post-TraumaticSurvivorsYoung AdultConceptsEmergency departmentAmygdala subregionsPTSD diagnosisGeneral hospital emergency departmentLeft amygdala volumeHospital emergency departmentRight hippocampus volumeCA1 hippocampal subregionRecent trauma survivorsTrauma survivorsCivilian trauma survivorsED admissionEligible participantsHippocampus volumeAmygdala volumeHippocampal subregionsVulnerability traitsDisorder pathogenesisClinical InterviewModerate evidenceHippocampus subregionsTrauma exposureStructural MRIRobust evidenceLower initial volumeEmotional numbing in PTSD is associated with lower amygdala reactivity to pain
Korem N, Duek O, Ben-Zion Z, Kaczkurkin AN, Lissek S, Orederu T, Schiller D, Harpaz-Rotem I, Levy I. Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology 2022, 47: 1913-1921. PMID: 35945274, PMCID: PMC9485255, DOI: 10.1038/s41386-022-01405-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAmygdala reactivityLower amygdala reactivityHigher pain responseLower amygdala activationAltered pain perceptionAmygdala activationProcessing of painAmygdala responseEmotional numbingPain correlateMild painPain processingPain thresholdPain responsePain perceptionPainControl groupPTSD groupStress disorderRobust reductionAmygdala activityCombat controlsAmygdalaEmotional numbing symptoms
2017
Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders
Korem N, Lange R, Hillard C, Akirav I. Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders. Neuroscience 2017, 357: 285-294. PMID: 28624572, DOI: 10.1016/j.neuroscience.2017.06.015.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderWnt/β-catenin pathwayNucleus accumbensΒ-catenin pathwayΒ-catenin levelsΒ-cateninCannabinoid CB1/2 receptor agonistCB1/2 receptor agonistEndocannabinoid N-arachidonylethanolamineStress-related disordersΒ-catenin expressionReceptor agonistEndocannabinoid systemTherapeutic effectN-arachidonylethanolamineDepressive symptomsDevelopment of psychopathologyImpaired extinctionRatsStress disorderFear memoryTrauma memoriesRapid recoveryReminders modelAccumbens
2015
Targeting the endocannabinoid system to treat anxiety-related disorders
Korem N, Zer-Aviv T, Ganon-Elazar E, Abush H, Akirav I. Targeting the endocannabinoid system to treat anxiety-related disorders. Journal Of Basic And Clinical Physiology And Pharmacology 2015, 27: 193-202. PMID: 26426887, DOI: 10.1515/jbcpp-2015-0058.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-traumatic stress disorderEndocannabinoid systemAnxiety-related disordersCommon self-reported reasonsAdministration of cannabinoidsEncouraging preclinical dataEffects of cannabinoidsAnxiety-like behaviorExogenous cannabinoidsPreclinical dataSelf-reported reasonsChronic usageUntoward effectsAnxiogenic effectsMouse modelPsychiatric disordersAnimal modelsPTSD patientsClinical settingPreclinical researchStress disorderAnxiety disordersCannabinoidsDisordersControl of emotions
2014
Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
Korem N, Akirav I. Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing. Neuropsychopharmacology 2014, 39: 2709-2722. PMID: 24897957, PMCID: PMC4200492, DOI: 10.1038/npp.2014.132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoxazinesBrainCannabinoid Receptor AgonistsCannabinoidsCuesDisease Models, AnimalElectroshockEmotionsExtinction, PsychologicalLong-Term PotentiationMaleMorpholinesNaphthalenesNeuronal PlasticityRats, Sprague-DawleyReceptors, CannabinoidReceptors, GlucocorticoidReflex, StartleSpace PerceptionStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderSituational remindersEmotional processingPrefrontal cortexTrauma exposureTraumatic eventsBasolateral amygdalaPTSD-like symptomsTrajectory of PTSDCB1/2 receptor agonistCB1 receptorsGlucocorticoid receptorImpaired extinctionSingle footshockStress disorderBrain areasFootshockCB1R expressionImpaired plasticityReceptor agonistDay 1Day 3ProcessingCA1Altered expression