2021
Computer vision applied to dual-energy computed tomography images for precise calcinosis cutis quantification in patients with systemic sclerosis
Chandrasekaran AC, Fu Z, Kraniski R, Wilson FP, Teaw S, Cheng M, Wang A, Ren S, Omar IM, Hinchcliff ME. Computer vision applied to dual-energy computed tomography images for precise calcinosis cutis quantification in patients with systemic sclerosis. Arthritis Research & Therapy 2021, 23: 6. PMID: 33407814, PMCID: PMC7788847, DOI: 10.1186/s13075-020-02392-9.Peer-Reviewed Original ResearchMeSH KeywordsCalcinosisComputersHumansImage Processing, Computer-AssistedNeural Networks, ComputerScleroderma, SystemicTomographyConceptsSSc patientsCalcinosis cutisCC lesionsSystemic sclerosisBland-Altman plotsConcordance correlation coefficientIndependent radiologistsLin's concordance correlation coefficientConfidence intervalsValid clinical trialsExpert musculoskeletal radiologistsSpearman correlation coefficientClinical trialsMusculoskeletal radiologistsPatientsBurden quantificationLesionsMean differenceGold standardRadiologistsCorrelation coefficientLonger lengthPhalanxSpearman's rhoValidation study
2020
High-throughput quantitative histology in systemic sclerosis skin disease using computer vision
Correia C, Mawe S, Lofgren S, Marangoni RG, Lee J, Saber R, Aren K, Cheng M, Teaw S, Hoffmann A, Goldberg I, Cowper SE, Khatri P, Hinchcliff M, Mahoney JM. High-throughput quantitative histology in systemic sclerosis skin disease using computer vision. Arthritis Research & Therapy 2020, 22: 48. PMID: 32171325, PMCID: PMC7071594, DOI: 10.1186/s13075-020-2127-0.Peer-Reviewed Original ResearchConceptsSystemic sclerosisFibrosis scoreQuantitative image featuresBiopsy scorePrimary cohortOutcome measuresSecondary cohortDiagnostic scoreSkin severity scoreSSc clinical trialsRodnan skin scoreLogistic regression modelsControl biopsiesRegression modelsSkin scoreSeverity scoreClinical hallmarkClinical trialsForearm biopsiesSSc skinBiopsy sectionsIndependent cohortPatient basisSSc biopsiesCollagen deposition