2008
Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade
ÅNEMAN A, TREGGIARI MM, BURGENER D, LAESSER M, STRASSER S, HADENGUE A. Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. Acta Anaesthesiologica Scandinavica 2008, 53: 203-209. PMID: 19094177, DOI: 10.1111/j.1399-6576.2008.01834.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCardiac Output, LowCardiac TamponadeDrug Evaluation, PreclinicalEndothelin Receptor AntagonistsEndothelin-1FemaleLactatesLiver CirculationMaleModels, AnimalOxygenOxygen ConsumptionPyridinesSplanchnic CirculationSus scrofaTetrazolesVascular ResistanceVasoconstrictionConceptsLaser Doppler flowMesenteric oxygen deliveryLow CO stateBaseline valuesCardiac tamponadeOxygen deliveryBlood flowPorcine modelPortal venous blood flowHepatic artery blood flowLow cardiac output stateET-1 blockadeMesenteric oxygen extractionMesenteric vascular resistanceArtery blood flowCardiac output stateNormal saline vehicleVenous blood flowMesenteric vasoconstrictionPortal pressureSplanchnic hypoperfusionVascular resistanceHepatic arterialEndothelin-1Liver protection
2006
Cerebral Autoregulation and CO2 Reactivity in Anterior and Posterior Cerebral Circulation During Sevoflurane Anesthesia
Rozet I, Vavilala MS, Lindley AM, Visco E, Treggiari M, Lam AM. Cerebral Autoregulation and CO2 Reactivity in Anterior and Posterior Cerebral Circulation During Sevoflurane Anesthesia. Anesthesia & Analgesia 2006, 102: 560-564. PMID: 16428561, DOI: 10.1213/01.ane.0000184817.10595.62.Peer-Reviewed Original ResearchConceptsCerebral autoregulationAutoregulatory indexBasilar arterySevoflurane anesthesiaHg PaCO2ASA physical status I patientsSmall-dose remifentanilCO2 reactivityElective orthopaedic surgeryArterial blood pressureMiddle cerebral arteryPosterior cerebral circulationStatus I patientsTranscranial Doppler ultrasonographyMAC of sevofluraneBlood flow velocityBlood pressurePosterior circulationCerebral arteryCerebral circulationI patientsPhenylephrine infusionDoppler ultrasonographyHealthy individualsLinear regression analysis