2022
Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders
Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V, Bunick CG. Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human Genomics 2022, 16: 1. PMID: 34991727, PMCID: PMC8733776, DOI: 10.1186/s40246-021-00374-9.Peer-Reviewed Original ResearchConceptsTissue-specific expression patternsKeratin genesExpression patternsHuman disease-causing variantsType II keratin genesGenotype-Tissue Expression (GTEx) projectIntermediate filament genesKeratin gene familyEarly metazoan evolutionGene expression patternsAmphibian genomesZebrafish genomeAnimal genomesParalogous proteinsMetazoan evolutionGene expansionChromosome 17q21.2Gene familyFilament genesSpecies survivalDivergent functionsExpression projectChromosomal segmentsChr 11Chr 15
2020
Recent insight into intermediate filament structure
Eldirany SA, Lomakin IB, Ho M, Bunick CG. Recent insight into intermediate filament structure. Current Opinion In Cell Biology 2020, 68: 132-143. PMID: 33190098, PMCID: PMC7925366, DOI: 10.1016/j.ceb.2020.10.001.Peer-Reviewed Original ResearchConceptsIntermediate filamentsAssembly mechanismVariable N-terminalMultiple cellular processesCentral rod domainIntermediate filament structureCoil 1BCellular processesStudy of keratinsTail domainFilament assemblyRod domainC-terminalN-terminalElectrostatic surfacePathologic mutationsKey playersFilament structureRecent insightsComplex formationProteinHuman tissuesGlial fibrillary acidic proteinAcidic proteinDomain