2001
Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2
Joseph T, Wooden R, Bryant A, Zhong M, Lu Z, Foster D. Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2. Biochemical And Biophysical Research Communications 2001, 289: 1019-1024. PMID: 11741292, DOI: 10.1006/bbrc.2001.6118.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell Transformation, NeoplasticCSK Tyrosine-Protein KinaseErbB ReceptorsGene ExpressionGenes, srcPhospholipase DProtein-Tyrosine KinasesRatsSignal TransductionSrc-Family KinasesTransfectionConceptsEpidermal growth factor receptorTransformation of cellsTyrosine kinaseElevated tyrosine kinase activityElevated expressionTyrosine kinase activityGTPase cascadeMembrane microdomainsPhospholipase D activityTransform cellsPLD genesGrowth factor receptorC-SrcMitogenic signalsGene productsDownstream targetsKinase activityOncogenic signalingPhospholipase D1PLD2Common genetic alterationsHuman cancersKinaseMalignant phenotypeGenetic alterationsNovel tumor-promoting property of tamoxifen.
Zhong M, Lu Z, Abbas T, Hornia A, Chatakondu K, Barile N, Kaplan P, Foster D. Novel tumor-promoting property of tamoxifen. Molecular Cancer Research 2001, 12: 187-92. PMID: 11331247.Peer-Reviewed Original ResearchConceptsTumor-promoting capabilitiesEstrogen antagonist propertiesEstrogen-mimetic effectsEffect of tamoxifenBreast cancer patientsYears of treatmentTumor-promoting phorbol ester TPATumor-promoting propertiesC-Src overexpressionEndometrial cancerCancer patientsRat fibroblastsTamoxifenPhorbol ester TPA
2000
Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts
Lu Z, Hornia A, Joseph T, Sukezane T, Frankel P, Zhong M, Bychenok S, Xu L, Feig L, Foster D. Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts. Molecular And Cellular Biology 2000, 20: 462-467. PMID: 10611224, PMCID: PMC85102, DOI: 10.1128/mcb.20.2.462-467.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCell LineCell Transformation, NeoplasticEnzyme ActivationEpidermal Growth FactorErbB ReceptorsFibroblastsGene ExpressionGenes, DominantGTP PhosphohydrolasesJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesMutationPhenotypePhospholipase DRal GTP-Binding ProteinsRas ProteinsRatsSignal TransductionTransfectionConceptsEGFR cellsAbsence of EGFEpidermal growth factor receptorGrowth factor receptorRas-dependent activationElevated phospholipase D activityEGF-induced activationOverexpression of PLD1Factor receptorRat fibroblastsDownstream effector moleculesRalA mutantsActivation of PLDPhospholipase D activityJun kinaseSmall GTPaseEGF receptorRalA.PLD activityPhospholipase DRalAEffector moleculesPLD1EGFMitogenic stimuli
1999
Antagonistic Effects of Protein Kinase C α and δ on Both Transformation and Phospholipase D Activity Mediated by the Epidermal Growth Factor Receptor
Hornia A, Lu Z, Sukezane T, Zhong M, Joseph T, Frankel P, Foster D. Antagonistic Effects of Protein Kinase C α and δ on Both Transformation and Phospholipase D Activity Mediated by the Epidermal Growth Factor Receptor. Molecular And Cellular Biology 1999, 19: 7672-7680. PMID: 10523655, PMCID: PMC84804, DOI: 10.1128/mcb.19.11.7672.Peer-Reviewed Original ResearchMeSH KeywordsAcetophenonesAnimalsBenzopyransCarbazolesCell Transformation, NeoplasticCells, CulturedCrosses, GeneticEpidermal Growth FactorErbB ReceptorsIndolesIsoenzymesModels, GeneticMutagenesis, InsertionalPhospholipase DProtein Kinase CProtein Kinase C-alphaProtein Kinase C-deltaRatsRecombinant ProteinsTetradecanoylphorbol Acetate