2002
Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
Zhong M, Lu Z, Foster D. Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 2002, 21: 1071-1078. PMID: 11850824, DOI: 10.1038/sj.onc.1205165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCaspase 9CaspasesCell LineCell Line, TransformedCell SurvivalCulture Media, Serum-FreeCytochrome c GroupDown-RegulationIsoenzymesPhosphatidylinositol 3-KinasesProtein Kinase CProtein Kinase C-deltaProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins pp60(c-src)RatsSignal TransductionTetradecanoylphorbol AcetateConceptsSurvival signalsSerum withdrawalPKC δApoptotic signalsTyrosine kinase c-SrcProtein kinase C δC-Src overexpressionKinase c-SrcCaspase-9 pathwayV-SrcRenders cellsApoptotic phenotypeApoptotic stressC-SrcSurvival pathwaysRat fibroblastsDownregulationApoptosisCellsPathwayOverexpressionPhenotypeFibroblastsSignals
2001
Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2
Joseph T, Wooden R, Bryant A, Zhong M, Lu Z, Foster D. Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2. Biochemical And Biophysical Research Communications 2001, 289: 1019-1024. PMID: 11741292, DOI: 10.1006/bbrc.2001.6118.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorTransformation of cellsTyrosine kinaseElevated tyrosine kinase activityElevated expressionTyrosine kinase activityGTPase cascadeMembrane microdomainsPhospholipase D activityTransform cellsPLD genesGrowth factor receptorC-SrcMitogenic signalsGene productsDownstream targetsKinase activityOncogenic signalingPhospholipase D1PLD2Common genetic alterationsHuman cancersKinaseMalignant phenotypeGenetic alterations
2000
Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts
Lu Z, Hornia A, Joseph T, Sukezane T, Frankel P, Zhong M, Bychenok S, Xu L, Feig L, Foster D. Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts. Molecular And Cellular Biology 2000, 20: 462-467. PMID: 10611224, PMCID: PMC85102, DOI: 10.1128/mcb.20.2.462-467.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCell LineCell Transformation, NeoplasticEnzyme ActivationEpidermal Growth FactorErbB ReceptorsFibroblastsGene ExpressionGenes, DominantGTP PhosphohydrolasesJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesMutationPhenotypePhospholipase DRal GTP-Binding ProteinsRas ProteinsRatsSignal TransductionTransfectionConceptsEGFR cellsAbsence of EGFEpidermal growth factor receptorGrowth factor receptorRas-dependent activationElevated phospholipase D activityEGF-induced activationOverexpression of PLD1Factor receptorRat fibroblastsDownstream effector moleculesRalA mutantsActivation of PLDPhospholipase D activityJun kinaseSmall GTPaseEGF receptorRalA.PLD activityPhospholipase DRalAEffector moleculesPLD1EGFMitogenic stimuli