2002
Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts
Zhong M, Joseph T, Jackson D, Beychenok S, Foster D. Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts. Biochemical And Biophysical Research Communications 2002, 298: 474-477. PMID: 12408976, DOI: 10.1016/s0006-291x(02)02495-6.Peer-Reviewed Original ResearchConceptsElevated PLD expressionPLD expressionPhospholipase DRat fibroblastsElevated expressionProtein kinase C deltaNormal rat fibroblastsElevated phospholipase D activityInducible expression systemCytochrome c releaseMitochondrial apoptosis pathwayADP-ribose polymerasePhospholipase D activityC deltaApoptotic insultsC releaseExpression systemTyrosine kinase expressionTransient transfectionTyrosine kinaseApoptosis pathwayCell transformationPLD activityAbsence of serumCaspase-3
1999
Antagonistic Effects of Protein Kinase C α and δ on Both Transformation and Phospholipase D Activity Mediated by the Epidermal Growth Factor Receptor
Hornia A, Lu Z, Sukezane T, Zhong M, Joseph T, Frankel P, Foster D. Antagonistic Effects of Protein Kinase C α and δ on Both Transformation and Phospholipase D Activity Mediated by the Epidermal Growth Factor Receptor. Molecular And Cellular Biology 1999, 19: 7672-7680. PMID: 10523655, PMCID: PMC84804, DOI: 10.1128/mcb.19.11.7672.Peer-Reviewed Original ResearchMeSH KeywordsAcetophenonesAnimalsBenzopyransCarbazolesCell Transformation, NeoplasticCells, CulturedCrosses, GeneticEpidermal Growth FactorErbB ReceptorsIndolesIsoenzymesModels, GeneticMutagenesis, InsertionalPhospholipase DProtein Kinase CProtein Kinase C-alphaProtein Kinase C-deltaRatsRecombinant ProteinsTetradecanoylphorbol Acetate