2002
Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts
Zhong M, Joseph T, Jackson D, Beychenok S, Foster D. Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts. Biochemical And Biophysical Research Communications 2002, 298: 474-477. PMID: 12408976, DOI: 10.1016/s0006-291x(02)02495-6.Peer-Reviewed Original ResearchConceptsElevated PLD expressionPLD expressionPhospholipase DRat fibroblastsElevated expressionProtein kinase C deltaNormal rat fibroblastsElevated phospholipase D activityInducible expression systemCytochrome c releaseMitochondrial apoptosis pathwayADP-ribose polymerasePhospholipase D activityC deltaApoptotic insultsC releaseExpression systemTyrosine kinase expressionTransient transfectionTyrosine kinaseApoptosis pathwayCell transformationPLD activityAbsence of serumCaspase-3
2000
Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts
Lu Z, Hornia A, Joseph T, Sukezane T, Frankel P, Zhong M, Bychenok S, Xu L, Feig L, Foster D. Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts. Molecular And Cellular Biology 2000, 20: 462-467. PMID: 10611224, PMCID: PMC85102, DOI: 10.1128/mcb.20.2.462-467.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCell LineCell Transformation, NeoplasticEnzyme ActivationEpidermal Growth FactorErbB ReceptorsFibroblastsGene ExpressionGenes, DominantGTP PhosphohydrolasesJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesMutationPhenotypePhospholipase DRal GTP-Binding ProteinsRas ProteinsRatsSignal TransductionTransfectionConceptsEGFR cellsAbsence of EGFEpidermal growth factor receptorGrowth factor receptorRas-dependent activationElevated phospholipase D activityEGF-induced activationOverexpression of PLD1Factor receptorRat fibroblastsDownstream effector moleculesRalA mutantsActivation of PLDPhospholipase D activityJun kinaseSmall GTPaseEGF receptorRalA.PLD activityPhospholipase DRalAEffector moleculesPLD1EGFMitogenic stimuli