2023
AAPM Task Group Report 238: 3D C‐arms with volumetric imaging capability*
Supanich M, Siewerdsen J, Fahrig R, Farahani K, Gang G, Helm P, Jans J, Jones K, Koenig T, Kuhls-Gilcrist A, Lin M, Riddell C, Ritschl L, Schafer S, Schueler B, Silver M, Timmer J, Trousset Y, Zhang J. AAPM Task Group Report 238: 3D C‐arms with volumetric imaging capability*. Medical Physics 2023, 50: e904-e945. PMID: 36710257, PMCID: PMC11584023, DOI: 10.1002/mp.16245.Peer-Reviewed Original ResearchMeSH KeywordsCone-Beam Computed TomographyImage Processing, Computer-AssistedImaging, Three-DimensionalPhantoms, ImagingRadiometryConceptsImage qualityGeometric calibrationSystem calibrationPhantom imagesService callsC-arm systemImage reconstructionVolumetric imaging capabilityImage acquisitionGeometric alignmentImage-guided radiation therapyData setsTesting approachCBCT systemC-arm cone beamC-armReconstruction characteristicsImage artifactsValuable dataC-arm CBCT systemImagesIGRT systemTask groupDifferent systemsCT image quality
2021
Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
Rexha I, Laage-Gaupp F, Chapiro J, Miszczuk MA, van Breugel JMM, Lin M, Konstantinidis M, Duran R, Gebauer B, Georgiades C, Hong K, Nezami N. Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma. Scientific Reports 2021, 11: 9337. PMID: 33927226, PMCID: PMC8085245, DOI: 10.1038/s41598-021-88426-x.Peer-Reviewed Original ResearchConceptsTotal tumor volumeConventional transarterial chemoembolizationTumor diameterIntrahepatic cholangiocarcinomaOverall survivalTumor areaICC patientsTumor volumeHigh tumor burden groupTumor analysisOS of patientsHazard ratioTransarterial chemoembolizationTumor burdenBurden groupConventional chemoembolizationHTB groupRetrospective analysisPatientsSurvival curvesMultivariate analysisChemoembolizationCholangiocarcinomaETVBaseline images
2020
Quantification of contrast-uptake as imaging biomarker for disease progression of renal cell carcinoma after tumor ablation
Tegel BR, Huber S, Savic LJ, Lin M, Gebauer B, Pollak J, Chapiro J. Quantification of contrast-uptake as imaging biomarker for disease progression of renal cell carcinoma after tumor ablation. Acta Radiologica 2020, 61: 1708-1716. PMID: 32216452, PMCID: PMC7529766, DOI: 10.1177/0284185120909964.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Renal CellContrast MediaDisease ProgressionFemaleHumansImaging, Three-DimensionalKidney NeoplasmsMaleMiddle AgedNeoplasm StagingRadiography, InterventionalRetrospective StudiesSensitivity and SpecificityTumor BurdenUltrasonography, InterventionalConceptsProgression-free survivalTotal tumor volumeRenal cell carcinomaCell carcinomaOdds ratioTumor volumeImaging biomarkersImage-guided thermal ablationPrognosis of patientsRENAL nephrometry scoreCox regression modelLargest tumor diameterLog-rank testKaplan-Meier plotsCross-sectional imagingSensitive imaging biomarkerMetastatic diseaseSecondary outcomesPrimary outcomeDistant metastasisNephrometry scoreTumor diameterOutcome parametersLesion vascularityTNM stage
2019
Quantitative Imaging Biomarkers for 90Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization
Schobert I, Chapiro J, Nezami N, Hamm CA, Gebauer B, Lin M, Pollak J, Saperstein L, Schlachter T, Savic LJ. Quantitative Imaging Biomarkers for 90Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization. Journal Of Nuclear Medicine 2019, 60: 1066-1072. PMID: 30655331, PMCID: PMC6681698, DOI: 10.2967/jnumed.118.219691.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiographyBiomarkersCarcinoma, HepatocellularEmbolization, TherapeuticFeasibility StudiesFemaleHumansImaging, Three-DimensionalLiverLiver NeoplasmsMagnetic Resonance ImagingMaleMicrospheresMiddle AgedMultimodal ImagingPrognosisRegression AnalysisRetrospective StudiesTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedTreatment OutcomeYttrium RadioisotopesConceptsNon-HCC patientsTransarterial radioembolizationHepatocellular carcinomaBaseline imagingTumor responseTumor volumeChild-Pugh class B patientsBaseline imaging featuresClass B patientsNormal liver ratiosTotal tumor volumeSPECT/CTContrast-enhanced MRIQuantitative European AssociationMultiphasic contrast-enhanced MRIInstitutional review boardHigh TNRPreprocedural MRIChild-PughB patientsLiver criteriaTumor burdenClinical parametersHepatic malignanciesRetrospective study
2016
3D Quantitative tumour burden analysis in patients with hepatocellular carcinoma before TACE: comparing single-lesion vs. multi-lesion imaging biomarkers as predictors of patient survival
Fleckenstein FN, Schernthaner RE, Duran R, Sohn JH, Sahu S, Zhao Y, Hamm B, Gebauer B, Lin M, Geschwind JF, Chapiro J. 3D Quantitative tumour burden analysis in patients with hepatocellular carcinoma before TACE: comparing single-lesion vs. multi-lesion imaging biomarkers as predictors of patient survival. European Radiology 2016, 26: 3243-3252. PMID: 26762942, PMCID: PMC4942412, DOI: 10.1007/s00330-015-4168-3.Peer-Reviewed Original ResearchConceptsHazard ratioOverall survivalTransarterial chemoembolizationBaseline MRIHepatocellular carcinomaTumor burdenDominant lesionTumor assessmentTumor volumeMultivariate cox proportional hazard ratiosCox proportional hazard ratiosCurrent radiological methodMethodsThis retrospective analysisProportional hazard ratiosBCLC staging systemKaplan-Meier plotsTumor diameterPatient survivalStaging systemHCC patientsMultiple lesionsLiver volumeRetrospective analysisLesion assessmentPatients
2015
Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma
Wang Z, Chen R, Duran R, Zhao Y, Yenokyan G, Chapiro J, Schernthaner R, Radaelli A, Lin M, Geschwind JF. Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma. CardioVascular And Interventional Radiology 2015, 38: 1548-1556. PMID: 26001366, PMCID: PMC4651808, DOI: 10.1007/s00270-015-1129-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyContrast MediaEthiodized OilFemaleFollow-Up StudiesHumansImage EnhancementImaging, Three-DimensionalLiverLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesTreatment OutcomeConceptsLipiodol depositionConventional transarterial chemoembolizationTumor responseOverall tumor volumeTumor volumeCE-MRIHepatocellular carcinomaTransarterial chemoembolizationTumor necrosisContrast-enhanced magnetic resonance imagingNecrotic tumour volumeResponse Evaluation CriteriaT-testMagnetic resonance imagingStudent's t-testMethodsThis IRBTarget lesionsRetrospective analysisSolid tumorsResonance imagingSpearman rank-order correlationPatientsCone-beam CTCBCTChemoembolizationRadiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement
Chockalingam A, Duran R, Sohn JH, Schernthaner R, Chapiro J, Lee H, Sahu S, Nguyen S, Geschwind JF, Lin M. Radiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement. European Radiology 2015, 26: 103-113. PMID: 25994198, PMCID: PMC4654989, DOI: 10.1007/s00330-015-3812-2.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationHCC patientsIpsilateral placementTumor enhancementHepatocellular carcinoma patientsROI placementContrast-enhanced MR imagingRadiologic-pathologic analysisArterial chemoembolizationCarcinoma patientsPathological correlationIntra-class correlationPatientsMR imagingClinical methodsMedian differencePathologyInterest placementHistopathologyMultimodality 3D Tumor Segmentation in HCC Patients Treated with TACE
Wang Z, Chapiro J, Schernthaner R, Duran R, Chen R, Geschwind JF, Lin M. Multimodality 3D Tumor Segmentation in HCC Patients Treated with TACE. Academic Radiology 2015, 22: 840-845. PMID: 25863795, PMCID: PMC4464945, DOI: 10.1016/j.acra.2015.03.001.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overAlgorithmsAntibiotics, AntineoplasticCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyDoxorubicinFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalKidney NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedMultidetector Computed TomographyMultimodal ImagingPattern Recognition, AutomatedPrognosisReproducibility of ResultsRetrospective StudiesSensitivity and SpecificitySubtraction TechniqueTreatment OutcomeThree-Dimensional Quantitative Assessment of Uterine Fibroid Response after Uterine Artery Embolization Using Contrast-Enhanced MR Imaging
Chapiro J, Duran R, Lin M, Werner JD, Wang Z, Schernthaner R, Savic LJ, Lessne ML, Geschwind JF, Hong K. Three-Dimensional Quantitative Assessment of Uterine Fibroid Response after Uterine Artery Embolization Using Contrast-Enhanced MR Imaging. Journal Of Vascular And Interventional Radiology 2015, 26: 670-678.e2. PMID: 25638750, PMCID: PMC4414730, DOI: 10.1016/j.jvir.2014.11.020.Peer-Reviewed Original ResearchMeSH KeywordsAdultContrast MediaEmbolization, TherapeuticFemaleHumansImaging, Three-DimensionalLeiomyomaMagnetic Resonance ImagingMiddle AgedRetrospective StudiesUterine ArteryUterine Neoplasms
2014
Identifying Staging Markers for Hepatocellular Carcinoma before Transarterial Chemoembolization: Comparison of Three-dimensional Quantitative versus Non–three-dimensional Imaging Markers
Chapiro J, Duran R, Lin M, Schernthaner RE, Wang Z, Gorodetski B, Geschwind JF. Identifying Staging Markers for Hepatocellular Carcinoma before Transarterial Chemoembolization: Comparison of Three-dimensional Quantitative versus Non–three-dimensional Imaging Markers. Radiology 2014, 275: 438-47. PMID: 25531387, PMCID: PMC4409467, DOI: 10.1148/radiol.14141180.Peer-Reviewed Original ResearchConceptsUnresectable hepatocellular carcinomaTransarterial chemoembolizationHepatocellular carcinomaTumor diameterHazard ratioTumor responseTumor volumeResponse rateCox proportional hazard ratiosStaging markersTumor response rateProportional hazard ratiosResponse Evaluation CriteriaSurvival of patientsKaplan-Meier analysisSingle-institution analysisBaseline magnetic resonance imagesHigh response rateInstitutional review boardOverall survivalLiver (EASL) guidelinesPatient cohortImaging markerRadiologic measurementsLarge lesionsAssessing tumor response after loco-regional liver cancer therapies: the role of 3D MRI
Chapiro J, Lin M, Duran R, Schernthaner RE, Geschwind JF. Assessing tumor response after loco-regional liver cancer therapies: the role of 3D MRI. Expert Review Of Anticancer Therapy 2014, 15: 199-205. PMID: 25371052, PMCID: PMC4304995, DOI: 10.1586/14737140.2015.978861.Peer-Reviewed Original ResearchMeSH KeywordsChemoembolization, TherapeuticHumansImaging, Three-DimensionalLiver NeoplasmsMagnetic Resonance ImagingReproducibility of ResultsTreatment OutcomeConceptsTumor responseResponse Evaluation CriteriaTumor response criteriaMajor clinical interestLiver cancer therapyLiver cancer lesionsClinical evidenceIntraarterial therapyCancer lesionsSolid tumorsResponse criteriaAnatomic methodsClinical interestImaging modalitiesCancer therapyTumor analysisTherapyMRILesionsTumorsRadiologic-Pathologic Analysis of Contrast-enhanced and Diffusion-weighted MR Imaging in Patients with HCC after TACE: Diagnostic Accuracy of 3D Quantitative Image Analysis
Chapiro J, Wood LD, Lin M, Duran R, Cornish T, Lesage D, Charu V, Schernthaner R, Wang Z, Tacher V, Savic LJ, Kamel IR, Geschwind JF. Radiologic-Pathologic Analysis of Contrast-enhanced and Diffusion-weighted MR Imaging in Patients with HCC after TACE: Diagnostic Accuracy of 3D Quantitative Image Analysis. Radiology 2014, 273: 746-758. PMID: 25028783, PMCID: PMC4263418, DOI: 10.1148/radiol.14140033.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularChemoembolization, TherapeuticContrast MediaDiffusion Magnetic Resonance ImagingFemaleGadolinium DTPAHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalLiver NeoplasmsMaleMiddle AgedNeoplasm StagingRetrospective StudiesSoftwareTreatment OutcomeConceptsPathologic tumor necrosisHepatocellular carcinoma lesionsTumor necrosisTransarterial chemoembolizationCarcinoma lesionsRadiologic–pathologic correlation studyTumor tissueMagnetic Resonance Imaging AssessmentDiagnostic accuracyInstitutional review board-approved retrospective studyOrthotopic liver transplantationTotal tumor volumeDiffusion-weighted MR imagingApparent diffusion coefficient (ADC) mapsNecrotic tumor tissueArterial phase MR imagesDiffusion coefficient mapsLast MR examinationLiver transplantationSurgical resectionLiver criteriaPathologic examinationRetrospective studyPhase MR imagesHistopathologic examinationThree-dimensional Evaluation of Lipiodol Retention in HCC after Chemoembolization A Quantitative Comparison between CBCT and MDCT
Wang Z, Lin M, Lesage D, Chen R, Chapiro J, Gu T, Tacher V, Duran R, Geschwind JF. Three-dimensional Evaluation of Lipiodol Retention in HCC after Chemoembolization A Quantitative Comparison between CBCT and MDCT. Academic Radiology 2014, 21: 393-399. PMID: 24507426, PMCID: PMC3979929, DOI: 10.1016/j.acra.2013.11.006.Peer-Reviewed Original ResearchAgedAntineoplastic AgentsCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyEthiodized OilFemaleHemostaticsHumansImaging, Three-DimensionalLiver NeoplasmsMaleMetabolic Clearance RateMiddle AgedMultidetector Computed TomographyReproducibility of ResultsSensitivity and SpecificityTissue DistributionTreatment Outcome
2013
Quantitative Assessment of Lipiodol Deposition after Chemoembolization: Comparison between Cone-Beam CT and Multidetector CT
Chen R, Geschwind J, Wang Z, Tacher V, Lin M. Quantitative Assessment of Lipiodol Deposition after Chemoembolization: Comparison between Cone-Beam CT and Multidetector CT. Journal Of Vascular And Interventional Radiology 2013, 24: 1837-1844. PMID: 24094672, PMCID: PMC3840104, DOI: 10.1016/j.jvir.2013.08.017.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyContrast MediaEthiodized OilFemaleHumansImaging, Three-DimensionalLinear ModelsLiver NeoplasmsMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesTumor BurdenWorkflowConceptsTransarterial chemoembolizationLipiodol depositionHepatocellular carcinomaMultidetector CTConventional transarterial chemoembolizationVolume of tumorMargin of tumorUnenhanced multidetector CTUnenhanced multidetectorLipiodol retentionChemoembolizationLiver parenchymaTumorsEntire tumorLiver contrastCone beamCone-beam CTCTImaging modalitiesCBCTPatientsLipiodolWhole tumorVolumetric measurementsTomographyImage Guidance for Endovascular Repair of Complex Aortic Aneurysms: Comparison of Two-dimensional and Three-dimensional Angiography and Image Fusion
Tacher V, Lin M, Desgranges P, Deux J, Grünhagen T, Becquemin J, Luciani A, Rahmouni A, Kobeiter H. Image Guidance for Endovascular Repair of Complex Aortic Aneurysms: Comparison of Two-dimensional and Three-dimensional Angiography and Image Fusion. Journal Of Vascular And Interventional Radiology 2013, 24: 1698-1706. PMID: 24035418, PMCID: PMC3888792, DOI: 10.1016/j.jvir.2013.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnatomic LandmarksAngiography, Digital SubtractionAortic AneurysmAortographyBlood Vessel Prosthesis ImplantationCone-Beam Computed TomographyContrast MediaEndovascular ProceduresFeasibility StudiesFemaleFluoroscopyHumansImaging, Three-DimensionalMaleMiddle AgedMultidetector Computed TomographyOperative TimePredictive Value of TestsRadiation DosageRadiographic Image Interpretation, Computer-AssistedRadiography, InterventionalRetrospective StudiesSoftwareTime FactorsTreatment OutcomeConceptsComplex aortic aneurysmsContrast medium volumeAortic aneurysmProcedure timeEndovascular repairComplex aneurysm repairJuxtarenal aortic aneurysmsContrast agent volumeSignificant differencesX-ray exposureSignificant reductionImage guidance groupThree-dimensional angiographyIntraprocedural fluoroscopyAneurysm repairConsecutive patientsPatient characteristicsEndovascular techniquesRenal arteryIF groupAneurysmsDAP valuesAngiographyGuidance groupStatistical differenceImage quality improvements in C-Arm CT (CACT) for liver oncology applications: Preliminary study in rabbits
Tacher V, Bhagat N, Rao P, Lin M, SchÄfer D, Noordhoek N, Eshuis P, Radaelli A, Liapi E, Grass M, Geschwind J. Image quality improvements in C-Arm CT (CACT) for liver oncology applications: Preliminary study in rabbits. Minimally Invasive Therapy & Allied Technologies 2013, 22: 297-303. PMID: 23837536, PMCID: PMC3859124, DOI: 10.3109/13645706.2013.788028.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsImaging, Three-DimensionalLiver Neoplasms, ExperimentalMaleMotionRabbitsTime FactorsTomography, X-Ray ComputedConceptsC-arm CTAdult male New Zealand white rabbitsMale New Zealand white rabbitsIntra-arterial therapyNon-target embolizationNew Zealand white rabbitsZealand white rabbitsFuture animal studiesLiver tumorsControl rabbitsNew imaging modalityOncology therapyAnimal studiesWhite rabbitsImaging protocolImaging modalitiesRabbitsSelective deliveryTherapyLesion detectionCTClinical environmentStudy improvementRespiratory motionPreliminary studySemiautomatic Volumetric Tumor Segmentation for Hepatocellular Carcinoma Comparison between C-arm Cone Beam Computed Tomography and MRI
Tacher V, Lin M, Chao M, Gjesteby L, Bhagat N, Mahammedi A, Ardon R, Mory B, Geschwind J. Semiautomatic Volumetric Tumor Segmentation for Hepatocellular Carcinoma Comparison between C-arm Cone Beam Computed Tomography and MRI. Academic Radiology 2013, 20: 446-452. PMID: 23498985, PMCID: PMC3602801, DOI: 10.1016/j.acra.2012.11.009.Peer-Reviewed Original Research
2012
Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization
Lin M, Pellerin O, Bhagat N, Rao P, Loffroy R, Ardon R, Mory B, Reyes D, Geschwind J. Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization. Journal Of Vascular And Interventional Radiology 2012, 23: 1629-1637. PMID: 23177109, PMCID: PMC3579576, DOI: 10.1016/j.jvir.2012.08.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic AgentsCarcinoma, HepatocellularChemoembolization, TherapeuticFemaleHumansImaging, Three-DimensionalLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPattern Recognition, AutomatedReproducibility of ResultsSensitivity and SpecificitySoftwareSoftware ValidationTreatment OutcomeTumor BurdenConceptsTranscatheter arterial chemoembolizationArterial chemoembolizationHepatocellular carcinomaDrug-eluting bead transcatheter arterial chemoembolizationSingle-institution prospective studyResponse Evaluation CriteriaContrast-enhanced magnetic resonanceHepatic tumor volumeSolid tumor measurementsThree-dimensional volumetric assessmentMagnetic resonanceIntraarterial therapyProspective studyTumor responseClinical correlationTumor measurementsTumor volumeTumor enhancementInterventional radiologistsPatientsVolumetric assessmentChemoembolizationEuropean AssociationVolume assessmentVoxel basis
2010
Evaluating tumors in transcatheter arterial chemoembolization (TACE) using dual-phase cone-beam CT
Lin M, Loffroy R, Noordhoek N, Taguchi K, Radaelli A, Blijd J, Balguid A, Geschwind J. Evaluating tumors in transcatheter arterial chemoembolization (TACE) using dual-phase cone-beam CT. Minimally Invasive Therapy & Allied Technologies 2010, 20: 276-281. PMID: 21082901, PMCID: PMC4337876, DOI: 10.3109/13645706.2010.536243.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationTumor-feeding vesselsParenchymal stainingTACE treatmentArterial chemoembolizationContrast injectionDual-phase cone-beam CTTumor feeding vesselsDrug-eluting beadsContrast-enhanced scansDegree of embolizationFeeding vesselsMR/CTSingle injectionCatheter positionInitial experienceCBCT scansCone-beam CTEmbolization effectConventional CTCTChemoembolizationC-armInjectionCBCT system