2024
Changes in Hoarding-Related Beliefs and Associated Neural Changes during a Simulated Discarding Task after Cognitive-Behavioral Treatment for Hoarding Disorder
Knowles K, Stevens M, Levy H, Tolin D. Changes in Hoarding-Related Beliefs and Associated Neural Changes during a Simulated Discarding Task after Cognitive-Behavioral Treatment for Hoarding Disorder. Journal Of Psychiatric Research 2024, 180: 473-481. PMID: 39547046, DOI: 10.1016/j.jpsychires.2024.11.017.Peer-Reviewed Original ResearchCognitive-behavioral therapyHoarding-related beliefsFunctional magnetic resonance imagingHoarding disorderNeural activityMaladaptive beliefsCourse of CBTGroup cognitive-behavioral therapyLeft anterior cingulate cortexLeft middle frontal gyrusAssociated with cognitive changesCognitive-behavioral treatmentAssociated with increased activityAnterior ventral insulaAnterior cingulate cortexMiddle frontal gyrusInferior temporal lobeLeft middle insulaCognitive-behavioralAssociated with specific changesFrontal gyrusCingulate cortexMiddle insulaNeural regionsVentral insula
2023
Changes in Neural Activity Following a Randomized Trial of Cognitive Behavioral Therapy for Hoarding Disorder
Tolin D, Levy H, Hallion L, Wootton B, Jaccard J, Diefenbach G, Stevens M. Changes in Neural Activity Following a Randomized Trial of Cognitive Behavioral Therapy for Hoarding Disorder. Journal Of Consulting And Clinical Psychology 2023, 91: 242-250. PMID: 36877480, PMCID: PMC10175200, DOI: 10.1037/ccp0000804.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyMedial intraparietal areaDorsal anterior cingulate cortexIntraparietal areaHD patientsRostral cingulateDorsolateral prefrontalBehavioral therapyVentral insular cortexDACC activationAnterior intraparietal areaNeural activityGroup cognitive behavioral therapyAnterior cingulate cortexRight dorsolateral prefrontalFunctional magnetic resonance imagingMagnetic resonance imagingCaudal cingulateClinical trialsInsular cortexRight amygdalaTherapeutic benefitSymptom reductionCingulate cortexResonance imaging
2013
Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Research 2013, 221: 142-148. PMID: 24389161, PMCID: PMC3946244, DOI: 10.1016/j.pscychresns.2013.11.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGo/NoGo taskFunctional magnetic resonance imagingOCD patientsHD patientsResponse inhibitionNoGo taskHealthy controlsGo/NoGo task performanceDistinct neural underpinningsRight orbitofrontal gyrusErrors of commissionNeural underpinningsOrbitofrontal activationTask performanceCorrect rejectsMagnetic resonance imagingHemodynamic activityFrontal hypoactivityNeural activityOrbitofrontal gyrusBehavioral dataHemodynamic responsePatientsPreliminary evidenceError processing in current and former cocaine users
Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging And Behavior 2013, 8: 87-96. PMID: 23949893, PMCID: PMC3925762, DOI: 10.1007/s11682-013-9247-y.Peer-Reviewed Original ResearchConceptsFormer cocaine usersError processingSupramarginal gyrusCocaine usersBOLD responseRight inferior parietal lobuleAspects of impulsivityAbstinent cocaine usersCocaine abuse/dependenceInferior parietal lobuleCocaine-dependent individualsCurrent cocaine usersCognitive compensationNeural differencesPrepotent responsesResponse inhibitionAbuse/dependenceCorrect rejectionsSpecific deficitsBOLD activityTrait measuresMaladaptive behaviorsParietal lobuleAddictive behaviorsNeural activity
2012
RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder.
Wegbreit E, Passarotti AM, Ellis JA, Wu M, Witowski N, Fitzgerald JM, Stevens MC, Pavuluri MN. RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder. Journal Of Affective Disorders 2012, 147: 304-311. PMID: 23261134, PMCID: PMC3606663, DOI: 10.1016/j.jad.2012.11.025.Peer-Reviewed Original ResearchConceptsFearful facesPrefrontal cortexNeutral facesRight dorsolateral prefrontal cortexEmotion-attention interactionsEnhanced neural processingVentrolateral prefrontal cortexEmotional processing regionsDorsolateral prefrontal cortexAdolescent bipolar disorderProbe taskEmotional facesPrefrontal activityNeural processingSpaced stimuliABD groupEmotional responsesProcessing regionsBilateral amygdalaDisorder exhibitMixed mood statesMood statesHealthy controlsNeural activityBipolar disorder exhibitNeural Mechanisms of Decision Making in Hoarding Disorder
Tolin DF, Stevens MC, Villavicencio AL, Norberg MM, Calhoun VD, Frost RO, Steketee G, Rauch SL, Pearlson GD. Neural Mechanisms of Decision Making in Hoarding Disorder. JAMA Psychiatry 2012, 69: 832-841. PMID: 22868937, PMCID: PMC3506167, DOI: 10.1001/archgenpsychiatry.2011.1980.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral CortexDecision MakingDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsExpressed EmotionFemaleGyrus CinguliHoarding DisorderHospitals, VoluntaryHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysObsessive BehaviorSickness Impact ProfileConceptsHealthy control subjectsObsessive-compulsive disorderAnterior cingulate cortexNeural mechanismsCingulate cortexBrain regionsNeural activityAppropriate emotional responsesFrontal brain regionsFunctional magnetic resonance imaging (fMRI) signalsPrevious neuroimaging studiesUnique diagnostic entityFunctional magnetic resonanceMagnetic resonance imaging signalsControl subjectsImpaired decisionInsula functionEmotional significanceAffective statesDepressive symptomsHoarding DisorderEmotional responsesNeuroimaging studiesPatientsPoor insight
2005
Low-dose estradiol alters brain activity
Stevens MC, Clark VP, Prestwood KM. Low-dose estradiol alters brain activity. Psychiatry Research 2005, 139: 199-217. PMID: 16084069, DOI: 10.1016/j.pscychresns.2005.04.004.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSustained attention taskAttention taskEvent-related functional magnetic resonance imagingThree-stimulus oddball taskTasks of learningAlters brain activityEstrogen replacement therapyCortical brain regionsOddball taskBehavioral performanceBrain activityPrefrontal cortexHemodynamic activityAnterior cingulateDose estrogen replacement therapyNeural activityParietal lobeBrain regionsBrain functionReplacement therapyTaskGroup participantsDouble-blind studyMotor cortex