2015
Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis
Karvellas CJ, Stravitz R, Battenhouse H, Lee WM, Schilsky ML, Group F. Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis. Liver Transplantation 2015, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAnalgesics, Non-NarcoticBrain EdemaChemical and Drug Induced Liver InjuryChi-Square DistributionFemaleHumansHypothermia, InducedLiver Failure, AcuteLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioRegistriesRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute liver failureNon-APAP patientsALF patientsTherapeutic hypothermiaAPAP patientsLiver failureUS Acute Liver Failure Study GroupAcute Liver Failure Study GroupImpact of THMulticenter retrospective cohort analysisTransplant-free survival rateEnd-stage liver diseaseAPAP-ALF patientsRetrospective cohort studyRetrospective cohort analysisAcetaminophen patientsSpontaneous survivalCerebral edemaCohort studyProspective trialHepatic encephalopathyLiver diseaseTracheal infectionGrade IIIWorse outcomes
2013
730
McGinniss J, Marshall P, Schilsky M, Honiden S. 730. Critical Care Medicine 2013, 41: a180-a181. DOI: 10.1097/01.ccm.0000439968.28678.d4.Peer-Reviewed Original ResearchCerebral edemaInvasive ICP monitorTH groupICP monitorALF patientsIntracranial pressureExact testMolecular adsorbent recirculating system dialysisRed blood cell transfusion requirementsYale-New Haven HospitalHepatic synthetic functionNon-TH groupMcg/dlChronic liver diseaseSimilar demographic dataFresh frozen plasmaUncontrolled intracranial pressureFeasible therapeutic modalityFisher's exact testNew Haven HospitalAdvanced hepatic encephalopathyT-testStudent's t-testTH initiationTransfusion requirements