2023
Synthetic preimplantation factor plus hypothermia treatment reverses perinatal hypoxic-ischemic encephalopathy in rats
Paidas M, Ranganathan R, Melians M, Hussain H, Sriramajayam K, Muller M, Ahmad A, Dietrich D, Bramlett H, Barnea E, Jayakumar A. Synthetic preimplantation factor plus hypothermia treatment reverses perinatal hypoxic-ischemic encephalopathy in rats. American Journal Of Obstetrics And Gynecology 2023, 228: s365. DOI: 10.1016/j.ajog.2022.11.639.Peer-Reviewed Original Research
2015
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
Barnea E, Almogi-Hazan O, Or R, Mueller M, Ria F, Weiss L, Paidas M. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult. Pharmacology & Therapeutics 2015, 156: 10-25. PMID: 26546485, DOI: 10.1016/j.pharmthera.2015.10.008.Peer-Reviewed Original ResearchConceptsPreImplantation FactorNeurological disordersAdverse maternal environmentSynthetic preimplantation factorEarly adverse eventsHigh safety profileFast track designationComplex neurological disorderEmbryonic-maternal interactionColon ulcerationPIF's effectHost diseaseLeukemia effectAdverse eventsLiver inflammationTransplant acceptanceBrain infectionNeuroprotective effectsAutoimmune disordersImmune suppressionNeuroprotective propertiesImmune modulationNeonatal prematuritySupraphysiological dosesSkin ulceration
2013
Synthetic PreImplantation Factor (sPIF)# neuroprotective role in intracranial stem cell transplantation: Encephalopathy of prematurity rat model
Müller M, Paidas M, Schöberlein A, Messerli M, Barnea E, Surbek D. Synthetic PreImplantation Factor (sPIF)# neuroprotective role in intracranial stem cell transplantation: Encephalopathy of prematurity rat model. Zeitschrift Für Geburtshilfe Und Neonatologie 2013, 217 DOI: 10.1055/s-0033-1361330.Peer-Reviewed Original ResearchSynthetic preimplantation factorStem cell transplantationPreImplantation FactorNeuroprotective roleCell transplantationRat model
2012
PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells
Barnea ER, Kirk D, Ramu S, Rivnay B, Roussev R, Paidas MJ. PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells. American Journal Of Obstetrics And Gynecology 2012, 207: 313.e1-313.e11. PMID: 23021695, DOI: 10.1016/j.ajog.2012.07.017.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsPreImplantation FactorSynthetic PIFBlood mononuclear cellsLymphocyte reactionMononuclear cellsImmune cellsSystemic effectsNaïve peripheral blood mononuclear cellsSynthetic preimplantation factorSystemic antiinflammatory effectMixed lymphocyte reactionImmune-modulatory propertiesTumor necrosis factorGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSPIF effectNonpregnant patientsDiabetes mellitusMale patientsAntiinflammatory effectsIL-4Immune modulationSubset populationsAntiinflammatory response
2010
A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells
Paidas MJ, Krikun G, Huang SJ, Jones R, Romano M, Annunziato J, Barnea ER. A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells. American Journal Of Obstetrics And Gynecology 2010, 202: 459.e1-459.e8. PMID: 20452489, PMCID: PMC2867836, DOI: 10.1016/j.ajog.2010.03.024.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsDown syndrome cell adhesion moleculeSyndrome cell adhesion moleculeGlobal gene expressionProtein arraysQuantitative mass spectrometryPreImplantation FactorBinding protein 1B-cell lymphoma protein 2PIF interactionProteomic analysisProteomic investigationCell adhesion moleculeInsulin-degrading enzymeGene expressionPathway analysisApoptotic pathwayApoptotic processToll-like receptor 5Protein 2Amino acid peptideProtein 1Protein 15Synthetic preimplantation factorEndometrial stromal cells