2015
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
Barnea E, Almogi-Hazan O, Or R, Mueller M, Ria F, Weiss L, Paidas M. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult. Pharmacology & Therapeutics 2015, 156: 10-25. PMID: 26546485, DOI: 10.1016/j.pharmthera.2015.10.008.Peer-Reviewed Original ResearchConceptsPreImplantation FactorNeurological disordersAdverse maternal environmentSynthetic preimplantation factorEarly adverse eventsHigh safety profileFast track designationComplex neurological disorderEmbryonic-maternal interactionColon ulcerationPIF's effectHost diseaseLeukemia effectAdverse eventsLiver inflammationTransplant acceptanceBrain infectionNeuroprotective effectsAutoimmune disordersImmune suppressionNeuroprotective propertiesImmune modulationNeonatal prematuritySupraphysiological dosesSkin ulceration
2012
PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells
Barnea ER, Kirk D, Ramu S, Rivnay B, Roussev R, Paidas MJ. PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells. American Journal Of Obstetrics And Gynecology 2012, 207: 313.e1-313.e11. PMID: 23021695, DOI: 10.1016/j.ajog.2012.07.017.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsPreImplantation FactorSynthetic PIFBlood mononuclear cellsLymphocyte reactionMononuclear cellsImmune cellsSystemic effectsNaïve peripheral blood mononuclear cellsSynthetic preimplantation factorSystemic antiinflammatory effectMixed lymphocyte reactionImmune-modulatory propertiesTumor necrosis factorGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSPIF effectNonpregnant patientsDiabetes mellitusMale patientsAntiinflammatory effectsIL-4Immune modulationSubset populationsAntiinflammatory response