2017
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity. Current Biology 2017, 27: 1915-1927.e5. PMID: 28669757, PMCID: PMC5698909, DOI: 10.1016/j.cub.2017.05.089.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCircadian ClocksDrosophila melanogasterDrosophila ProteinsLocomotionMaleNeuropeptidesReceptors, Cell SurfaceConceptsLocomotor activitySubesophageal zonePeptidergic circuitsPars intercerebralisCorticotropin-releasing factorVentral nerve cordSite of actionReceptor 1Motor outputCircadian locomotor activityNerve cordNeuronsRelevant receptorsDrosophila brainHr rhythmsCircadian driveRhythmFeeding rhythmDiuretic hormone 44Minimal effectActivity rhythmsBehavioral rhythmsCircadian locomotionCircadian controlCord
2016
Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics
Raccuglia D, McCurdy LY, Demir M, Gorur-Shandilya S, Kunst M, Emonet T, Nitabach MN. Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. ENeuro 2016, 3: eneuro.0080-16.2016. PMID: 27588305, PMCID: PMC4994068, DOI: 10.1523/eneuro.0080-16.2016.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPeripheral responsesGABA receptorsSensory neuronsContrast enhancementOSN axon terminalsInhibitory GABA receptorsPresynaptic GABAAxon terminalsDrosophila olfactory sensory neuronsPresynaptic terminalsNervous systemAuditory stimuliTemporal edgeOlfactory systemTime courseNeuronsInnate behavioral responsesReceptorsOptical electrophysiologyTemporal contrast enhancementBehavioral responsesLateral inhibitionResponseGABA
2015
Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body
Sitaraman D, Aso Y, Rubin GM, Nitabach MN. Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body. Frontiers In Neural Circuits 2015, 9: 73. PMID: 26617493, PMCID: PMC4637407, DOI: 10.3389/fncir.2015.00073.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedDopaminergic NeuronsDrosophila melanogasterImmunohistochemistryModels, AnimalMushroom BodiesNeural PathwaysSleep
2014
Sensory determinants of behavioral dynamics in Drosophila thermotaxis
Klein M, Afonso B, Vonner AJ, Hernandez-Nunez L, Berck M, Tabone CJ, Kane EA, Pieribone VA, Nitabach MN, Cardona A, Zlatic M, Sprecher SG, Gershow M, Garrity PA, Samuel AD. Sensory determinants of behavioral dynamics in Drosophila thermotaxis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 112: e220-e229. PMID: 25550513, PMCID: PMC4299240, DOI: 10.1073/pnas.1416212112.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBehavior, AnimalCalcium SignalingDrosophila melanogasterGangliaLarvaLocomotionOptogeneticsThermoreceptorsThermosensingMiniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation
Choi BJ, Imlach WL, Jiao W, Wolfram V, Wu Y, Grbic M, Cela C, Baines RA, Nitabach MN, McCabe BD. Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation. Neuron 2014, 82: 618-634. PMID: 24811381, PMCID: PMC4022839, DOI: 10.1016/j.neuron.2014.03.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedDrosophilaMiniature Postsynaptic PotentialsNeuromuscular JunctionPresynaptic TerminalsSynapsesSynaptic TransmissionConceptsSynaptic terminal growthMiniature neurotransmissionStructural maturationSingle synaptic vesiclesExchange factorDevelopmental roleRac1 GTPaseEssential functionsMiniature eventsSynaptic vesiclesSynapse maturationMiniature postsynaptic potentialsTerminal growthMaturationTranssynaptic processSmall amplitude eventsPostsynaptic potentialsGlutamatergic synapsesPresynaptic neuronsChemical synapseNeurotransmissionGTPaseVesiclesGuanineSynapses