2017
Membrane Currents, Gene Expression, and Circadian Clocks
Allen CN, Nitabach MN, Colwell CS. Membrane Currents, Gene Expression, and Circadian Clocks. Cold Spring Harbor Perspectives In Biology 2017, 9: a027714. PMID: 28246182, PMCID: PMC5411696, DOI: 10.1101/cshperspect.a027714.Peer-Reviewed Original ResearchConceptsCircadian clockGene ClockMembrane electrical activityCyclic adenosine monophosphateCircadian clock neuronsCircadian outputClock neuronsGenetic clockGene expressionCircadian oscillatorIntracellular CaAdenosine monophosphateFeedback loopPathwayClockHuman healthAction potential firing patternsMammalianActivityAction potential firingNightly reductionsMultiple typesExpressionMembrane currentsCircadian pattern
2013
O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination
Li MD, Ruan HB, Hughes ME, Lee JS, Singh JP, Jones SP, Nitabach MN, Yang X. O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination. Cell Metabolism 2013, 17: 303-310. PMID: 23395176, PMCID: PMC3647362, DOI: 10.1016/j.cmet.2012.12.015.Peer-Reviewed Original ResearchConceptsCircadian clockProtein modificationNutrient-sensing pathwaysO-GlcNAc signalingHexosamine biosynthesis pathwayCovalent protein modificationBiosynthesis pathwayGlcNAc transferaseNutritional signalsClock oscillationsO-GlcNAcylationAberrant circadian rhythmsClock targetsOGT expressionCircadian oscillationsUbiquitinationN-acetylglucosamineNutrient fluxesMetabolic oscillationsBMAL1GenesPathwayCircadian rhythmKey mechanismClock