Michael Nanna, MD, MHS, FSCAI, FACC
Assistant Professor of Internal Medicine (Cardiovascular Medicine)Cards
About
Research
Overview
Medical Research Interests
Cardiology
Publications
2025
Moving towards precision medicine for older adults with non-ST-segment elevation myocardial infarction
Nouri A, Nanna M. Moving towards precision medicine for older adults with non-ST-segment elevation myocardial infarction. Heart 2025, heartjnl-2025-325817. PMID: 40037762, DOI: 10.1136/heartjnl-2025-325817.Peer-Reviewed Original ResearchCombined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis.
Singh S, Garg A, Tantry U, Bliden K, Gurbel P, Kochar A, Nanna M, Damluji A. Combined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis. Journal Of Invasive Cardiology 2025 PMID: 39993271, DOI: 10.25270/jic/24.00312.Peer-Reviewed Original ResearchCalcified coronary lesionsProcedural success rateCoronary lesionsIntravascular lithotripsyCoronary perforationRisk of procedural complicationsRisk of adverse CV eventsAcute procedural successSuccess rateAcute coronary syndromeAdverse CV eventsTarget vessel revascularizationSeverely calcified coronary lesionsRandom-effects modelTreatment of severely calcified coronary lesionsPeriprocedural complicationsPooled proportionProcedural complicationsProcedural successCV deathCoronary syndromeCV eventsFollow-upProcedural outcomesCV outcomesAnticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis
Chi K, Zarif T, Varrias D, Lee P, Chang Y, Song J, Osabutey A, Borkowski P, Chiang C, Chang Y, Lin Y, Nanna M, Nanna M. Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis. Heart 2025, heartjnl-2024-325288. PMID: 39915077, DOI: 10.1136/heartjnl-2024-325288.Peer-Reviewed Original ResearchPresence of patent foramen ovaleOral anticoagulantsRandomised controlled trialsCryptogenic strokeAtrial cardiopathyIschaemic strokeIschaemic stroke riskSafety of oral anticoagulantsRisk factorsSecondary prevention of cryptogenic strokeStroke riskMeta-analysisOptimal antithrombotic strategyRisk of recurrent ischaemic strokePatent foramen ovaleInteraction p valuePersonalised treatment strategiesSystematic reviewRecurrent ischaemic strokePreventing ischaemic strokeBleeding riskNo significant differenceAntithrombotic strategiesClinical characteristicsForamen ovaleQuality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial
Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Rogers C, Patel M, Baloch K, Chow B, Anstrom K, Vemulapalli S, Weir-McCall J, Stone G, Chew D, Douglas P, Investigators O. Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011414. PMID: 39895494, PMCID: PMC11837958, DOI: 10.1161/circoutcomes.124.011414.Peer-Reviewed Original ResearchConceptsQuality of lifeSAQ Summary ScoreSummary scoreOveral quality of lifeAssess quality of lifeGeneric health statusQuality of life outcomesBaseline SAQ scoresCoronary artery diseaseQuality of life assessmentFollow-up time pointsClinically meaningful differencesStable patientsFollow-upArtery diseaseEQ-5DHealth statusMonths postrandomizationSuspected coronary diseaseComponent scoresSatisfaction surveySuspected coronary artery diseaseTrial participantsStable chest painTest groupEconomic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial
Chew D, Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Davidson-Ray L, Baloch K, Rogers C, Patel M, Anstrom K, Curzen N, Vemulapalli S, Douglas P, Investigators O. Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011008. PMID: 39895495, PMCID: PMC11837965, DOI: 10.1161/circoutcomes.123.011008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, StableComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCost SavingsCost-Benefit AnalysisFemaleFractional Flow Reserve, MyocardialHospital CostsHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsChest painObstructive coronary artery diseaseCoronary computed tomographic angiographyStable chest painCoronary artery bypass surgeryLow-risk patientsSecondary end pointsPrimary composite of deathPrecision strategyComputed tomographic angiographyHealth care system perspectiveComposite of deathUS health care system perspectiveArtery bypass surgeryMedical costsMean cost differenceNonfatal myocardial infarctionCoronary artery diseaseIntention-to-treatPercutaneous coronary interventionUsual testsEstimated total medical costTotal medical costsClinical practice guidelinesRisk patientsSex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention
Gomez J, Park D, Eder M, An S, Lowenstern A, Kelsey M, Rymer J, Douglas P, Nanna M. Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention. Baylor University Medical Center Proceedings 2025, 38: 159-169. PMID: 39990004, PMCID: PMC11845020, DOI: 10.1080/08998280.2025.2452113.Peer-Reviewed Original ResearchIn-hospital outcomesIn-hospital mortalitySecondary outcomesReadmission ratesOdds of in-hospital mortalityPercutaneous coronary interventionCalculate odds ratiosInpatient percutaneous coronary interventionHazard of readmissionUnited States National Readmission DatabaseIn-hospital adverse outcomesPropensity score matchingHealth systemHospital characteristicsOdds of cardiac arrestSocioeconomic statusReimbursement implicationsSex differencesYears of ageOdds ratioReadmission riskCox proportional-hazardsLogistic regressionIn-hospital complicationsScore matchingInvasive Strategy for Older Patients with MI
Nanna M, Kochar A, Damluji A. Invasive Strategy for Older Patients with MI. New England Journal Of Medicine 2025, 392: 516-518. PMID: 39879601, PMCID: PMC11921868, DOI: 10.1056/nejmc2415597.Peer-Reviewed Original ResearchStabilizing Stable Coronary Artery Disease No Beta-Blocker, No Problem?
Chi K, Nanna M. Stabilizing Stable Coronary Artery Disease No Beta-Blocker, No Problem? JACC Advances 2025, 4: 101569. PMID: 39826439, PMCID: PMC11787414, DOI: 10.1016/j.jacadv.2024.101569.Peer-Reviewed Original ResearchThe DanGer of Using Age to Decide About Using Microaxial Flow Pumps in Cardiogenic Shock
Samsky M, Kadosh B, Nanna M, Rao S. The DanGer of Using Age to Decide About Using Microaxial Flow Pumps in Cardiogenic Shock. Journal Of The American College Of Cardiology 2025, 85: 604-605. PMID: 39818661, DOI: 10.1016/j.jacc.2024.11.035.Peer-Reviewed Original ResearchRisk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.
Mosher C, Osazuwa-Peters O, Nanna M, MacIntyre N, Que L, Palmer S, Jones W, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal Of The American Heart Association 2025, 14: e035010. PMID: 39791395, DOI: 10.1161/jaha.124.035010.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseSecondary prevention cohortPrevention cohortASCVD hospitalizationRisk of atherosclerotic cardiovascular diseaseHazard ratioHospital outcomesHigh riskRisk factorsCardiovascular disease eventsCardiovascular diseasePrimary prevention cohortIdentified multiple risk factorsRisk of cardiovascular disease eventsMultiple risk factorsPulmonary disease hospitalizationsObstructive pulmonary diseaseOlder AdultsHigh-risk patient cohortASCVD eventsDisease eventsHigh-risk patientsMeta-analyses
Clinical Trials
Current Trials
LIVEBETTER (a trial comparing the effectiveness and tolerability of medications in older adults with stable angina and multiple chronic conditions)
HIC ID2000034470RolePrincipal InvestigatorPrimary Completion Date05/30/2027Recruiting Participants
Academic Achievements & Community Involvement
Clinical Care
Overview
Michael Nanna, MD, is an interventional cardiologist specializing in coronary interventions, with a focus on treating older adults who have multiple chronic conditions. He provides treatments aimed at managing heart disease in simple, patient-friendly ways, ensuring that complex conditions are addressed comprehensively.
As an assistant professor of internal medicine at Yale School of Medicine, Dr. Nanna's research is centered on enhancing risk prediction, optimizing treatment utilization, and facilitating shared decision-making for older adults with cardiovascular concerns. His work includes developing predictive models to assess the risk of future cardiovascular and cognitive issues, thereby aiding in more informed treatment decisions.
“Preventive medication decisions in older adults are inherently more complex than in younger populations,” he explains. “The first step toward informed shared decision-making is an accurate estimate of upfront risk to inform potential benefits of therapy.”
Dr. Nanna received his medical training from Stony Brook University School of Medicine and completed his internal medicine residency at Yale New Haven Hospital. He pursued further training in cardiology and interventional cardiology at Duke University Medical Center.
Clinical Specialties
Interventional Cardiology; Cardiovascular Medicine
Fact Sheets
Heart Attack (Myocardial Infarction)
Learn More on Yale MedicineHeart Disease in Women
Learn More on Yale MedicineBlood Clots in Veins, Heart and Lungs
Learn More on Yale MedicineOff-pump Coronary Artery Bypass Grafting (CABG) with Multiple Arterial Grafts
Learn More on Yale Medicine
Yale Medicine News
News
News
- January 03, 2025
Building Clinical Capacity in Cardiovascular Medicine Across the Caribbean
- November 18, 2024Source: The Seattle Times
8 Factors That Can Raise Your Heart Disease Risk
- November 07, 2024Source: The New York Times
8 Factors That Can Raise Your Heart Disease Risk
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
Get In Touch
Contacts
Appointment Number
Mailing Address
Cardiovascular Medicine
333 Cedar St.
New Haven, CT 06510
United States
Locations
Patient Care Locations
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