2021
Chronic UV radiation–induced RORγt+ IL-22–producing lymphoid cells are associated with mutant KC clonal expansion
Lewis JM, Monico PF, Mirza FN, Xu S, Yumeen S, Turban JL, Galan A, Girardi M. Chronic UV radiation–induced RORγt+ IL-22–producing lymphoid cells are associated with mutant KC clonal expansion. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2016963118. PMID: 34504008, PMCID: PMC8449378, DOI: 10.1073/pnas.2016963118.Peer-Reviewed Original ResearchConceptsChronic UV exposureLangerhans cellsIL-22Cutaneous carcinogenesisCutaneous squamous cell carcinoma (cSCC) developmentChronic ultraviolet radiation exposureSquamous cell carcinoma developmentClonal expansionEpidermal Langerhans cellsToll-like receptorsSkin cancer preventionGreatest risk factorDouble-deficient miceUltraviolet radiation exposureKey immune componentsImmune shiftKC growthIL-17ARisk factorsCancer preventionT cellsImmune responseCarcinoma developmentIntracellular CD3Immune components
2020
Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies.
Suozzi K, Turban J, Girardi M. Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies. The Yale Journal Of Biology And Medicine 2020, 93: 55-67. PMID: 32226337, PMCID: PMC7087054.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaBasal cell carcinomaCell carcinomaRisk factorsMajor environmental risk factorSquamous cell carcinomaAdditional risk factorsEnvironmental risk factorsDevelopment of melanomaUltraviolet radiation exposureLifestyle modificationTopical therapyImmune statusCutaneous carcinogenesisImmune factorsCell malignant transformationDrug Administration regulationsInsufficient evidenceMultifactorial mechanismsSkin cancerMalignant transformationFavorable aestheticsTumor developmentClonal expansionRadiation exposure
2018
Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents
Suh H, Lewis J, Fong L, Ramseier JY, Carlson K, Peng Z, Yin ES, Saltzman WM, Girardi M. Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents. Bioengineering & Translational Medicine 2018, 4: 129-140. PMID: 30680324, PMCID: PMC6336670, DOI: 10.1002/btm2.10092.Peer-Reviewed Original ResearchPredicting non-melanoma skin cancer via a multi-parameterized artificial neural network
Roffman D, Hart G, Girardi M, Ko CJ, Deng J. Predicting non-melanoma skin cancer via a multi-parameterized artificial neural network. Scientific Reports 2018, 8: 1701. PMID: 29374196, PMCID: PMC5786038, DOI: 10.1038/s41598-018-19907-9.Peer-Reviewed Original ResearchConceptsNon-melanoma skin cancerFamily historySkin cancerUVR exposureHistory of strokePotential predictive parametersNon-cancer casesFamily history informationUltraviolet radiation exposureDiabetic statusSmoking statusHeart diseaseRisk factorsExercise habitsHispanic ethnicityPredictive parametersAdult survey dataEarly detectionRadiation exposureROC curveHealth informationPersonal health informationNovel associationsCancerExposure