2021
Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles
Hu JK, Suh HW, Qureshi M, Lewis JM, Yaqoob S, Moscato ZM, Griff S, Lee AK, Yin ES, Saltzman WM, Girardi M. Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2020575118. PMID: 33526595, PMCID: PMC7896333, DOI: 10.1073/pnas.2020575118.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaNonsurgical treatmentSkin cancerTumor cell surfaceIntratumoral drug deliveryHistologic cureCutaneous malignanciesSurgical excisionTherapeutic standardTumor burdenTumor immunotherapyTumor injectionCommon malignancyCell carcinomaSCC tumorsNonsurgical alternativeTherapeutic efficacyD postinjectionNanoparticle drug delivery systemsChemotherapeutic agentsSuperficial tumorsTumorsLocal deliveryEnhanced survivalPercutaneous delivery
2002
Transimmunization, a novel approach for tumor immunotherapy
Berger CL, Hanlon D, Kanada D, Girardi M, Edelson RL. Transimmunization, a novel approach for tumor immunotherapy. Transfusion And Apheresis Science 2002, 26: 205-216. PMID: 12126207, DOI: 10.1016/s1473-0502(02)00014-9.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaImmune responseTumor antigensPotent antigen presenting cellsAnti-tumor immune responseExtracorporeal photopheresis (ECP) treatmentDendritic cell immunotherapyT-cell lymphomaAntigen presenting cellsPeripheral blood monocytesApoptotic tumor cellsApoptotic CTCL cellsPhotopheresis treatmentRejection episodesHost diseaseOvernight incubation periodTumor epitopesImmature DCsCell immunotherapyTumor immunotherapyAutoimmune diseasesDC differentiationInflammatory cytokinesPresenting cellsCell lymphoma