2001
Methylprednisolone and Acute Spinal Cord Injury
Bracken M. Methylprednisolone and Acute Spinal Cord Injury. Spine 2001, 26: s47-s54. PMID: 11805609, DOI: 10.1097/00007632-200112151-00010.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryMethodologic qualitySystematic reviewImproved functional recoveryHigh methodologic qualityNeurologic recoveryClinical recoveryPharmacologic therapyFunctional recoveryRandomized trialsInjury trialsCochrane LibraryEffective therapySurgical trialsEarly treatmentFurther trialsTherapeutic interventionsInjuryMeSH headingsMethylprednisoloneScore improvementPatientsEvidence base
1992
The Second National Acute Spinal Cord Injury Study.
Young W, Bracken M. The Second National Acute Spinal Cord Injury Study. Journal Of Neurotrauma 1992, 9 Suppl 1: s397-405. PMID: 1588630.Peer-Reviewed Original ResearchConceptsSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudySpinal cord injuryNeurologic scoresCord injuryInjury studiesHuman spinal cord injurySpinal cord injury careSevere spinal cord injuryBeneficial effectsSignificant beneficial effectNeurologic recoverySuch patientsPatient populationInjury careLumbosacral segmentsFunctional assessmentLesion siteInjury severityPatientsSensory functionMultivariate analysisMethylprednisolone
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose