2016
Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil gelatinase-associated lipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-associated lipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion
2015
The North American Fetal Therapy Network Consensus Statement
Emery SP, Bahtiyar MO, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 125: 1236-1243. PMID: 25932853, DOI: 10.1097/aog.0000000000000723.Peer-Reviewed Original ResearchConceptsMonochorionic gestationsNorth American Fetal Therapy NetworkUnequal placental sharingDetection of complicationsUnique disease processDichorionic gestationsUltrasonographic surveillanceEarly referralPlacental sharingPermanent disabilityConsensus statementPrenatal managementBetter outcomesDisease processClinical practiceGestationSingle placentaTherapy NetworkEarly detectionComplicationsVascular connectionsDeathSurveillanceReferralAngioarchitectureAmniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth
Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Abdel-Razeq SS, Shook LL, Bahtiyar MO, Buhimschi IA. Amniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth. American Journal Of Reproductive Immunology 2015, 73: 507-521. PMID: 25605324, PMCID: PMC4430418, DOI: 10.1111/aji.12362.Peer-Reviewed Original ResearchConceptsMyeloid differentiation 2Preterm birthSMD-2Fetal membranesInflammation-induced preterm birthHuman AFIntra-amniotic inflammatory responseInfection-induced preterm birthIntra-amniotic inflammationIL-6 levelsNormal pregnancy outcomeDifferentiation 2MD-2 mRNATime-dependent fashionPregnancy outcomesImmunohistochemistry findingsTLR4 ligandInflammatory cytokinesInflammatory responseHost responseMRNA expressionLevel of expressionWestern blottingHistological localizationAF samplesThe North American Fetal Therapy Network Consensus Statement
Bahtiyar MO, Emery SP, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 125: 118-123. PMID: 25560113, DOI: 10.1097/aog.0000000000000599.Peer-Reviewed Original ResearchConceptsMonochorionic gestationsNorth American Fetal Therapy NetworkOverall perinatal morbidityUnique disease processBetter patient outcomesDisproportionate disease burdenPerinatal morbidityPregnancy complicationsPrompt referralRegional treatment centreMultidisciplinary careCommon placentaDisease burdenPatient outcomesComprehensive counselingConsensus statementFetal disordersFetal surgeryDisease processTreatment centersTherapy NetworkGestationEarly detectionComplicationsMedical institutions