2017
Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery
Wilpers AB, Kennedy HP, Wall D, Funk M, Bahtiyar MO. Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery. Journal Of Obstetric Gynecologic & Neonatal Nursing 2017, 46: 456-464. PMID: 28390224, DOI: 10.1016/j.jogn.2017.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxiety DisordersCase-Control StudiesCongenital AbnormalitiesFemaleFetusHumansMaternal AgeMothersNew EnglandPilot ProjectsPregnancyPregnancy OutcomePregnancy Trimester, SecondPregnancy Trimester, ThirdPregnancy, High-RiskPrenatal DiagnosisProspective StudiesReference ValuesRisk AssessmentUltrasonography, PrenatalConceptsNurse care coordinatorsFetal anomaliesMaternal ageMaternal anxietyAnxiety scoresComparison pilot studyOlder maternal ageEarly third trimesterHealth history dataU.S. academic medical centersFetal care centersAcademic medical centerMean state anxiety scoreSpielberger State-Trait Anxiety InventoryMental health issuesState-Trait Anxiety InventoryEmotional supportThird trimesterCare coordinatorsMedical recordsRisk factorsCare centerMedical CenterState anxiety scoresPregnancy
2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, PMCID: PMC11588317, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroupEvidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil gelatinase-associated lipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-associated lipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion
2011
Neoadjuvant and Adjuvant Chemotherapy of Cervical Cancer
McCaffrey R, Bahtiyar M, Kohorn EI, Chambers JT, Schwartz PE, Chambers SK. Neoadjuvant and Adjuvant Chemotherapy of Cervical Cancer. International Journal Of Gynecological Cancer 2011, 21: 535-544. PMID: 21436702, DOI: 10.1097/igc.0b013e31820c4c8d.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAntineoplastic Combined Chemotherapy ProtocolsBleomycinCarcinoma, AdenosquamousCarcinoma, Squamous CellChemotherapy, AdjuvantCisplatinFemaleFluorouracilHumansLeucovorinMaximum Tolerated DoseMethotrexateMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingProspective StudiesSurvival RateTreatment OutcomeUterine Cervical NeoplasmsYoung AdultConceptsLymph nodesRadiation therapyResponse rateSurvival ratePathologic complete response rateCisplatin-based neoadjuvant chemotherapyAdjuvant chemotherapy armComplete response rateConsolidation radiation therapyStage IIB cancerDisease-free survivalHigh-risk featuresPercent of patientsPositive lymph nodesPostoperative radiation therapyChemotherapy response rateAdjuvant casesAdjuvant chemotherapyChemotherapy armChemotherapy eraNeoadjuvant groupNonsquamous histologyNeoadjuvant chemotherapyAdjuvant groupOverall survival
2010
Interpretation of Amniotic Fluid White Blood Cell Count in “Bloody Tap” Amniocenteses in Women With Symptoms of Preterm Labor
Abdel-Razeq SS, Buhimschi IA, Bahtiyar MO, Rosenberg VA, Dulay AT, Han CS, Werner EF, Thung S, Buhimschi CS. Interpretation of Amniotic Fluid White Blood Cell Count in “Bloody Tap” Amniocenteses in Women With Symptoms of Preterm Labor. Obstetrics And Gynecology 2010, 116: 344-354. PMID: 20664395, PMCID: PMC4142228, DOI: 10.1097/aog.0b013e3181e8fec6.Peer-Reviewed Original ResearchConceptsWhite blood cellsAmniotic fluid white blood cellBlood cell countWBC countAmniotic fluidBloody tapAmniotic fluid white blood cell countCell countAmniotic fluid WBC countRBC/White blood cell countPositive amniotic fluid cultureMaternal WBC countRed blood cell countCells/Number of neutrophilsAbsence of inflammationSetting of inflammationAmniotic fluid culturePositive likelihood ratioAmniotic fluid samplesIntraamniotic inflammationPreterm laborConsecutive womenFluid cultureNormative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome
Abdel-Razeq SS, Campbell K, Funai EF, Kaplan LJ, Bahtiyar MO. Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome. American Journal Of Obstetrics And Gynecology 2010, 203: 149.e1-149.e4. PMID: 20417482, DOI: 10.1016/j.ajog.2010.02.055.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal CavityAdultBlood Pressure DeterminationBody Mass IndexCesarean SectionCompartment SyndromesFemaleGestational AgeHumansLogistic ModelsManometryPostoperative CarePostoperative ComplicationsPostpartum PeriodPregnancyPressureProbabilityProspective StudiesReference ValuesRisk AssessmentSupine PositionUrinary BladderConceptsBody mass indexIntraabdominal pressureArterial hypertensionSemirecumbent positionHigher body mass indexGeneral surgical populationAbdominal compartment syndromeHigh intraabdominal pressureNormal arterial pressureHypertension rangeHypertensive disordersSurgical populationArterial pressureCesarean sectionCompartment syndromeGestational ageMass indexPostpartum womenBladder pressurePatientsHypertensionSupineNormative valuesPotential implicationsGravidityThe role of urinary soluble endoglin in the diagnosis of pre‐eclampsia: comparison with soluble fms‐like tyrosine kinase 1 to placental growth factor ratio
Buhimschi C, Baumbusch M, Dulay A, Lee S, Wehrum M, Zhao G, Bahtiyar M, Pettker C, Ali U, Funai E, Buhimschi I. The role of urinary soluble endoglin in the diagnosis of pre‐eclampsia: comparison with soluble fms‐like tyrosine kinase 1 to placental growth factor ratio. BJOG An International Journal Of Obstetrics & Gynaecology 2010, 117: 321-330. PMID: 19943826, DOI: 10.1111/j.1471-0528.2009.02434.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, CDBiomarkersChronic DiseaseDiagnosis, DifferentialEndoglinFemaleGrowth HormoneHumansHypertensionPlacental HormonesPre-EclampsiaPregnancyPregnancy Complications, CardiovascularProspective StudiesReceptors, Cell SurfaceSensitivity and SpecificityVascular Endothelial Growth Factor Receptor-1Young AdultConceptsSoluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Tyrosine kinase-1Placental growth factor ratioGrowth factor ratioSoluble endoglinDiagnosis of PEGestational agePlGF ratioChronic hypertensionHealthy controlsPreterm PEUrinary levelsSevere PEMild PEWeeks of GATertiary referral university hospitalKinase 1Prospective observational cohortSoluble endoglin levelsReferral university hospitalWeeks of gestationIdentification of womenSeverity of PEUrine of women
2009
Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth
Azpurua H, Dulay AT, Buhimschi IA, Bahtiyar MO, Funai E, Abdel-Razeq SS, Luo G, Bhandari V, Copel JA, Buhimschi CS. Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth. American Journal Of Obstetrics And Gynecology 2009, 200: 203.e1-203.e11. PMID: 19185102, PMCID: PMC3791328, DOI: 10.1016/j.ajog.2008.11.001.Peer-Reviewed Original ResearchConceptsCord blood IL-6End-diastolic blood flowRenal artery pulsatility indexArtery pulsatility indexBlood IL-6Amniotic fluid indexIntraamniotic inflammationResistance indexPulsatility indexPreterm birthIL-6Blood flowSerum blood urea nitrogen levelAF IL-6 levelsInflammation-associated preterm birthRenal artery resistance indexSystolic/diastolic ratioBlood urea nitrogen levelsAge-reference rangeCord blood interleukinRenal vascular bedIL-6 levelsHours of lifeUrea nitrogen levelsBlood interleukin
2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester