2019
Cesarean Scar Pregnancy, Incidence, and Recurrence: Five-Year Experience at a Single Tertiary Care Referral Center
Grechukhina O, Deshmukh U, Fan L, Kohari K, Abdel-Razeq S, Bahtiyar M, Sfakianaki A. Cesarean Scar Pregnancy, Incidence, and Recurrence: Five-Year Experience at a Single Tertiary Care Referral Center. Obstetric Anesthesia Digest 2019, 39: 98-99. DOI: 10.1097/01.aoa.0000557687.83837.90.Peer-Reviewed Original ResearchCesarean scar pregnancyScar pregnancyTreatment modalitiesSingle tertiary care referral centerTertiary care referral centerYale-New Haven HospitalLife-threatening complicationsNumerous treatment modalitiesTertiary care centerOptimal treatment modalityFive-year experiencePrevious hysterotomySac implantsPregnancy outcomesReferral centerPatient counselingCare centerTreatment decisionsPregnancyAvailable literaturePresent studyModalitiesHysterotomyComplicationsRecurrence
2018
Cesarean Scar Pregnancy, Incidence, and Recurrence
Grechukhina O, Deshmukh U, Fan L, Kohari K, Abdel-Razeq S, Bahtiyar MO, Sfakianaki AK. Cesarean Scar Pregnancy, Incidence, and Recurrence. Obstetrics And Gynecology 2018, 132: 1285-1295. PMID: 30303911, DOI: 10.1097/aog.0000000000002940.Peer-Reviewed Original ResearchMeSH KeywordsAbortifacient Agents, NonsteroidalAdultCesarean SectionCicatrixCombined Modality TherapyCurettageFemaleHumansHysteroscopyMethotrexatePotassium ChloridePregnancyPregnancy RatePregnancy, EctopicRecurrenceTertiary Care CentersUterine Artery EmbolizationUterine Balloon TamponadeWatchful WaitingYoung AdultConceptsCesarean scar pregnancyScar pregnancySubsequent pregnancy outcomeLocal methotrexatePregnancy outcomesTreatment modalitiesRecurrent cesarean scar pregnancyBilateral uterine artery embolizationElectronic medical record reviewYale-New Haven HospitalSubsequent spontaneous conceptionViable intrauterine pregnancyPrior cesarean deliveryMedical record reviewTime of diagnosisUterine artery embolizationPotassium chloride injectionFetal cardiac activityProducts of conceptionIntrauterine pregnancyPregnancy characteristicsSystemic methotrexateExpectant managementMethotrexate therapyArtery embolization
2016
Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil gelatinase-associated lipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-associated lipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion
2015
Amniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth
Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Abdel-Razeq SS, Shook LL, Bahtiyar MO, Buhimschi IA. Amniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth. American Journal Of Reproductive Immunology 2015, 73: 507-521. PMID: 25605324, PMCID: PMC4430418, DOI: 10.1111/aji.12362.Peer-Reviewed Original ResearchConceptsMyeloid differentiation 2Preterm birthSMD-2Fetal membranesInflammation-induced preterm birthHuman AFIntra-amniotic inflammatory responseInfection-induced preterm birthIntra-amniotic inflammationIL-6 levelsNormal pregnancy outcomeDifferentiation 2MD-2 mRNATime-dependent fashionPregnancy outcomesImmunohistochemistry findingsTLR4 ligandInflammatory cytokinesInflammatory responseHost responseMRNA expressionLevel of expressionWestern blottingHistological localizationAF samples
2008
Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth
Buhimschi C, Rosenberg V, Dulay A, Thung S, Sfakianaki A, Bahtiyar M, Buhimschi I. Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth. American Journal Of Perinatology 2008, 25: 175-187. PMID: 18425720, DOI: 10.1055/s-2008-1061497.Peer-Reviewed Original ResearchConceptsPreterm birthSignificant public health problemMost preterm birthsAdverse pregnancy outcomesWeeks of gestationPublic health problemVariety of interventionsNeonatal outcomesPregnancy outcomesDecidual hemorrhagePremature infantsPremature birthLikely multifactorialPathophysiological pathwaysHealth problemsPathophysiological conditionsProteomic biomarkersOxidative stressBirthExcessive stretchingOutcomesHemorrhageGestationInfantsEtiology