2020
Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence
Castelo-Branco C, Gambacciani M, Cano A, Minkin M, Rachoń D, Ruan X, Beer A, Schnitker J, Henneicke-von Zepelin H, Pickartz S. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Climacteric 2020, 24: 109-119. PMID: 33021111, DOI: 10.1080/13697137.2020.1820477.Peer-Reviewed Original ResearchConceptsClimacteric symptomsMenopausal symptomsBetter benefit-risk profileLow-dose transdermal estradiolICR/Evidence-based treatment optionsEstrogen-sensitive organsEstrogen-sensitive tissuesPsychological menopausal symptomsMinor adverse eventsBenefit-risk profileEvidence of hepatotoxicityGood safety profileStandardized mean differenceHormone-dependent diseasesSystematic literature searchTransdermal estradiolAdverse eventsGood tolerabilitySafety profileTreatment optionsSt. John's wortHerbal therapyHormone levelsClinical data
2011
Suspected black cohosh hepatotoxicity
Naser B, Schnitker J, Minkin M, de Arriba S, Nolte K, Osmers R. Suspected black cohosh hepatotoxicity. Menopause The Journal Of The North American Menopause Society 2011, 18: 366-375. PMID: 21228727, DOI: 10.1097/gme.0b013e3181fcb2a6.Peer-Reviewed Original ResearchConceptsIsopropanolic black cohosh extractClinical trialsPostmenopausal womenLiver functionAlanine aminotransferaseAspartate aminotransferaseBlack cohoshPopular herbal treatmentPlacebo-controlled studyMonths of treatmentLiver function valuesStandardized mean differenceBlack cohosh extractMenopausal symptomsHerbal treatmentHepatotoxicity casesMean differenceAdverse effectsAminotransferaseTrialsWomenNonsignificant effectDescriptive statisticsMonthsΓ-glutamyltranspeptidase