2024
A Patient With Type 1 Diabetes and Acute Rhinosinusitis
Roman F, Azar M, Trubin P. A Patient With Type 1 Diabetes and Acute Rhinosinusitis. JAMA 2024, 331: 1586-1587. PMID: 38630502, DOI: 10.1001/jama.2024.0642.Peer-Reviewed Original Research
2023
Current Concepts in the Diagnosis and Management of Pneumocystis Pneumonia in Solid Organ Transplantation
Trubin P, Azar M. Current Concepts in the Diagnosis and Management of Pneumocystis Pneumonia in Solid Organ Transplantation. Infectious Disease Clinics Of North America 2023, 37: 617-640. PMID: 37142510, DOI: 10.1016/j.idc.2023.03.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsHumansImmunocompromised HostOrgan TransplantationPneumocystis cariniiPneumonia, PneumocystisTrimethoprim, Sulfamethoxazole Drug CombinationConceptsSolid organ transplant recipientsOrgan transplant recipientsFirst-choice agentsSolid organ transplantationAppropriate clinical contextTransplant recipientsInterstitial pneumoniaTrimethoprim-sulfamethoxazoleOptimal treatmentPneumocystis pneumoniaOrgan transplantationInfection manifestsPrevention strategiesNucleic acid amplificationDiagnostic testingRadiographic imagingTissue samplingClinical contextLung fluidCurrent conceptsHost susceptibilityPneumoniaAcid amplificationTreatmentProphylaxis
2022
Into the unknown: Diagnosing mysterious brain lesions
Kassab I, Isada C, Azar MM, Sarsam N, Jiang M, Camelo‐Piragua S, Kaul D, Malinis M. Into the unknown: Diagnosing mysterious brain lesions. Transplant Infectious Disease 2022, 24: e13829. PMID: 35307917, DOI: 10.1111/tid.13829.Peer-Reviewed Case Reports and Technical NotesConceptsBrain abscessesImmune statusPancreas-kidney transplant recipientsCentral nervous system infectionBartonella henselaeMetagenomic next-generation sequencingCSF metagenomic next-generation sequencingMultiple brain abscessesVisceral organ involvementPatient's immune statusNervous system infectionCat-scratch diseaseTransplant recipientsOcular involvementOrgan involvementSystem infectionNeurological manifestationsCat bitesBrain lesionsDiagnostic approachNext-generation sequencingAbscessZoonotic pathogensClinicopathological conferenceHenselae
2020
Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults
Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults. CHEST Journal 2020, 159: 1356-1371. PMID: 33217418, DOI: 10.1016/j.chest.2020.11.008.Peer-Reviewed Original ResearchConceptsFinal clinical diagnosisDiagnostic yieldFungal pneumoniaImmunocompromised adultsMicrobiologic diagnosisAntimicrobial stewardshipMicrobiologic testingClinical diagnosisClinical metagenomicsCommunity-acquired pneumoniaStandard of careDiagnosis of pneumoniaAdult patientsRadiologic findingsBacterial pneumoniaBAL fluidProspective studyViral pneumoniaBacterial causePneumoniaDiagnostic utilityStudy designDiagnosisAdultsHypothetical impactDiagnosis of oesophageal mucormycosis managed with medical therapy alone
Ringer M, Pischel L, Azar MM. Diagnosis of oesophageal mucormycosis managed with medical therapy alone. BMJ Case Reports 2020, 13: e236869. PMID: 33093060, PMCID: PMC7583061, DOI: 10.1136/bcr-2020-236869.Peer-Reviewed Original ResearchConceptsIdarubicin/cytarabineLiposomal amphotericin BAcute myeloid leukemiaFebrile neutropeniaInduction chemotherapyPosaconazole therapyClinical characteristicsMedical therapySurgical morbiditySurgical interventionAggressive infectionDevastating manifestationMyeloid leukemiaCT scanInvasive moldsMucormycosisLebanese menAmphotericin BPatientsDiagnosisTherapyReportOdynophagiaNeutropeniaThrombocytopeniaCurrent Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes
Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes. Seminars In Respiratory And Critical Care Medicine 2020, 41: 013-030. PMID: 32000281, DOI: 10.1055/s-0039-1698429.Peer-Reviewed Original ResearchMeSH KeywordsAmphotericin BAntifungal AgentsHistoplasmaHistoplasmosisHumansImmunocompromised HostItraconazolePneumoniaRadiographyConceptsDisseminated diseaseCurrent evidence-based approachesProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseSelf-limiting diseaseLiposomal amphotericin BManagement of histoplasmosisEvidence-based approachHistoplasmosis syndromeImmunocompetent patientsPulmonary diseaseClinical presentationCrohn's diseasePreferred agentClinical manifestationsCommon conditionMilder casesAmphotericin BHistoplasmosisAmphotericin B.DiseaseEpidemiologyGlobal diseaseEmerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift.
Azar MM, Gaston DC, Kotton CN, Malinis MF. Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift. Transplantation 2020, 104: 1358-1384. PMID: 31972701, DOI: 10.1097/tp.0000000000003123.BooksConceptsHematopoietic stem cell transplantationInfected transplant recipientsInfectious disease specialistsStem cell transplantationBlood culture specimensArray of pathogensTransplant recipientsTransplant cliniciansClinical outcomesDisease specialistsCell transplantationTransplant infectionsMagnetic resonance-based methodsMicrobiology diagnosticsSolid organsCulture specimensMolecular testingMolecular panelResistance determinantsInfectionOutcomesDiagnostic microbiologyResonance-based methodsPatientsTransplantation
2019
Allogeneic stem cell transplantation and combination antiretroviral therapy: cautions, complications, and considerations
Shallis RM, Gleeson S, Azar M, Malinis M, Xu ML, Seropian SE, Gowda L, Zeidan AM. Allogeneic stem cell transplantation and combination antiretroviral therapy: cautions, complications, and considerations. Leukemia & Lymphoma 2019, 60: 2584-2587. PMID: 30943051, DOI: 10.1080/10428194.2019.1594221.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Central nervous system histoplasmosis
Wheat J, Myint T, Guo Y, Kemmer P, Hage C, Terry C, Azar MM, Riddell J, Ender P, Chen S, Shehab K, Cleveland K, Esguerra E, Johnson J, Wright P, Douglas V, Vergidis P, Ooi W, Baddley J, Bamberger D, Khairy R, Vikram H, Jenny-Avital E, Sivasubramanian G, Bowlware K, Pahud B, Sarria J, Tsai T, Assi M, Mocherla S, Prakash V, Allen D, Passaretti C, Huprikar S, Anderson A. Central nervous system histoplasmosis. Medicine 2018, 97: e0245. PMID: 29595679, PMCID: PMC5895412, DOI: 10.1097/md.0000000000010245.Peer-Reviewed Original ResearchConceptsCentral nervous system histoplasmosisPercent of patientsCerebrospinal fluidAmphotericin BCentral nervous system involvementSingle-center case seriesNervous system involvementLiposomal amphotericin BCenter case seriesOutcome of treatmentAnti-Histoplasma antibodiesRecognition of infectionPatients 54 yearsCNS histoplasmosisDeoxycholate formulationDisseminated histoplasmosisMost patientsAntigen testingAntibody testingCase seriesImmunodeficiency syndromeHistoplasma antigenHistoplasmosis infectionSystem involvementYear survivalCase 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure
Hibbert KA, Shepard JO, Lane RJ, Azar MM. Case 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure. New England Journal Of Medicine 2018, 378: 182-190. PMID: 29320657, DOI: 10.1056/nejmcpc1712222.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdenoviridaeAdenoviridae InfectionsAdultAntiviral AgentsCidofovirCytosineDiagnosis, DifferentialFemaleHumansImmunocompromised HostLeukemia, Myeloid, AcuteLungNasopharynxOpportunistic InfectionsOrganophosphonatesRadiography, ThoracicRenal InsufficiencyRespiratory InsufficiencyStem Cell TransplantationTomography, X-Ray ComputedViral Load
2017
Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States
Azar MM, Zhang X, Assi R, Hage C, Wheat LJ, Malinis MF. Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States. Medical Mycology 2017, 56: 896-899. PMID: 29228334, DOI: 10.1093/mmy/myx120.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedConnecticutFemaleHistoplasmosisHIV InfectionsHumansImmunocompromised HostMaleMiddle AgedRetrospective StudiesTravel-Related IllnessConceptsHuman immunodeficiency virusHistoplasmosis casesEpidemiology of histoplasmosisNon-endemic areasSymptom onsetAntigen testingMedian timeImmunodeficiency virusActive histoplasmosisNonendemic areasRetrospective analysisEndemic areasEpidemiological characterizationHistoplasmosisNew HavenDaysPatientsEpidemiologyDiagnosisCasesCase 30-2017
Bhattacharyya RP, Flores EJ, Azar MM. Case 30-2017. New England Journal Of Medicine 2017, 377: 1274-1282. PMID: 28953442, DOI: 10.1056/nejmcpc1706100.Peer-Reviewed Case Reports and Technical NotesCase 26-2017
Letourneau AR, Price MC, Azar MM. Case 26-2017. New England Journal Of Medicine 2017, 377: 770-778. PMID: 28834480, DOI: 10.1056/nejmcpc1616402.Peer-Reviewed Case Reports and Technical Notes
2016
Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines.
Azar MM, Malinis MF. Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines. American Journal Of Tropical Medicine And Hygiene 2016, 95: 70-4. PMID: 26976880, PMCID: PMC4944712, DOI: 10.4269/ajtmh.16-0063.Peer-Reviewed Case Reports and Technical NotesConceptsBone involvementDisseminated histoplasmosisFoot woundsPapular rashProtean manifestationsFinal diagnosisUnusual manifestationSkin lesionsDimorphic fungus Histoplasma capsulatumHistoplasmosisFungus Histoplasma capsulatumHistoplasma capsulatumDiseaseManifestationsRashOsteomyelitisPatientsLesionsDiagnosisHistoplasmosis
Wheat LJ, Azar MM, Bahr NC, Spec A, Relich RF, Hage C. Histoplasmosis. Infectious Disease Clinics Of North America 2016, 30: 207-227. PMID: 26897068, DOI: 10.1016/j.idc.2015.10.009.Books
2015
Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature
Azar MM, Assi R, Patel N, Malinis MF. Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. Mycopathologia 2015, 181: 425-433. PMID: 26687073, DOI: 10.1007/s11046-015-9975-1.Peer-Reviewed Case Reports and Technical NotesConceptsInternal carotid arteryFungal mycotic aneurysmsMycotic aneurysmSphenoid sinusitisICA aneurysmsSphenoid sinusEORTC/MSG criteriaInternal Carotid Artery AssociatedFungal sphenoid sinusitisLiposomal amphotericin B.Parent vessel sacrificeInvasive fungal infectionsDuration of antimicrobialsEffective antifungal therapyDevastating complicationSurgical debridementEndoscopic resectionAngioinvasive infectionVessel sacrificeCase reportAntifungal therapyCoil embolizationIdeal treatmentCavernous sinusCarotid arteryHistoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management
Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management. Seminars In Respiratory And Critical Care Medicine 2015, 36: 729-745. PMID: 26398539, DOI: 10.1055/s-0035-1562899.BooksMeSH KeywordsAmphotericin BAntifungal AgentsGeography, MedicalHistoplasmaHistoplasmosisHumansImmunocompromised HostItraconazoleLungMediastinal DiseasesPneumoniaRadiographyConceptsMost patientsPulmonary diseaseAcute pulmonary diseaseChronic cavitary pneumoniaCommon endemic mycosisProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseEvaluation of patientsLiposomal amphotericin BDate evidence-based approachGranulomatous inflammatory diseaseDiagnosis of histoplasmosisEvidence-based approachMediastinal manifestationsCavitary pneumoniaDisseminated diseaseClinical presentationCrohn's diseasePreferred agentClinical syndromeAnaerobic infectionsInflammatory diseasesEndemic mycosis