2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2023
Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report
Miller C, Taylor-Salmon E, Emuren L, Landry M, Gershon A, Miller G. Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report. BMC Infectious Diseases 2023, 23: 854. PMID: 38057696, PMCID: PMC10698951, DOI: 10.1186/s12879-023-08809-5.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVZV reactivationVaccine-strain varicella-zoster virusSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Latent varicella zoster virusSymptomatic COVID-19 infectionRespiratory syndrome coronavirus 2SARS-CoV2 infectionSyndrome coronavirus 2COVID-19 infectionVaccine-type strainsSARS-CoV-2Vesicular rashPediatric patientsSignificant morbidityClinical syndromeCoronavirus 2Single doseCase reportGeneral populationMechanical traumaDisease processHZ casesPhysiologic stress
2013
Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection
Lott JP, Liu K, Landry ML, Nix WA, Oberste MS, Bolognia J, King B. Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection. Journal Of The American Academy Of Dermatology 2013, 69: 736-741. PMID: 24035209, PMCID: PMC5843477, DOI: 10.1016/j.jaad.2013.07.024.Peer-Reviewed Original ResearchConceptsCV-A6 infectionAtypical HFMDCV-A6Acute viral illnessArea of dermatitisCoxsackievirus A6 infectionDiagnostic laboratory evaluationMouth diseaseEnterovirus 71 infectionWidespread cutaneous lesionsReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionAssociated systemic symptomsMucocutaneous lesionsViral illnessAtopic dermatitisCutaneous findingsCase seriesClinical featuresCutaneous lesionsEnterovirus infectionSystemic symptomsSingle institutionPolymerase chain reactionDiagnostic evaluationComparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens
Gitman MR, Ferguson D, Landry ML. Comparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens. Journal Of Clinical Microbiology 2013, 51: 3765-3769. PMID: 24006008, PMCID: PMC3889765, DOI: 10.1128/jcm.01413-13.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overChildChild, PreschoolClinical Laboratory TechniquesCosts and Cost AnalysisFemaleFluorescent Antibody TechniqueHerpes SimplexHumansInfantInfant, NewbornMaleMiddle AgedPolymerase Chain ReactionSensitivity and SpecificitySimplexvirusTime FactorsVirus CultivationYoung Adult
2010
The Molecular Diagnosis of Parechovirus Infection: Has the Time Come?
Landry ML. The Molecular Diagnosis of Parechovirus Infection: Has the Time Come? Clinical Infectious Diseases 2010, 50: 362-363. PMID: 20047495, DOI: 10.1086/649864.Peer-Reviewed Original Research
2009
Cytospin-Enhanced Immunofluorescence and Impact of Sample Quality on Detection of Novel Swine Origin (H1N1) Influenza Virus
Landry ML, Ferguson D. Cytospin-Enhanced Immunofluorescence and Impact of Sample Quality on Detection of Novel Swine Origin (H1N1) Influenza Virus. Journal Of Clinical Microbiology 2009, 48: 957-959. PMID: 20042632, PMCID: PMC2832425, DOI: 10.1128/jcm.01678-09.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsChildChild, PreschoolClinical Laboratory TechniquesFluorescent Antibody Technique, DirectHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanNasopharynxReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityVirologyYoung AdultConceptsNovel swine-origin influenza virusesSwine-origin influenza virusImmunofluorescence antibody testingReal-time reverse transcriptase PCRCycle threshold valuesPCR-positive resultsPediatric patientsCDC assayAntibody testingNasopharyngeal swabsReverse transcriptase-PCRSwine influenzaInfluenza virusTranscriptase-PCRPositive samplesPatientsPositive resultsInfluenzaSwabsCytospinsEmergent US adenovirus 3 strains associated with an epidemic and serious disease
Lebeck MG, McCarthy TA, Capuano AW, Schnurr DP, Landry ML, Setterquist SF, Heil GL, Kilic S, Gray GC. Emergent US adenovirus 3 strains associated with an epidemic and serious disease. Journal Of Clinical Virology 2009, 46: 331-336. PMID: 19854101, PMCID: PMC2806089, DOI: 10.1016/j.jcv.2009.09.023.Peer-Reviewed Original ResearchConceptsClinical diseaseSevere diseaseSevere clinical diseaseYears of ageRisk factor modelingRisk factorsChronic diseasesAdenovirus type 3Emergent strainsPrevalent serotypesHAdV3DiseaseMultivariate modelingType 3Serious diseaseRare strainsNovel variantsRestriction enzyme analysisAdenovirus 3Genomic characterizationEnzyme analysisStatistical analysisUS laboratoriesPersonsVariantsRhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age
Piotrowska Z, Vázquez M, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age. The Pediatric Infectious Disease Journal 2009, 28: 25-29. PMID: 19057454, PMCID: PMC4639321, DOI: 10.1097/inf.0b013e3181861da0.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusHRV-positive childrenHuman rhinovirusSyncytial virusAge groupsDiagnostic laboratoriesRespiratory tract diseaseMajor respiratory pathogenRate of infectionYears of ageSimilar age groupAsymptomatic childrenRespiratory specimenAsymptomatic groupRespiratory infectionsHRV infectionHospitalization ratesPolymerase chain reactionTract diseaseRespiratory pathogensHRV isolatesMajor causeStudy periodSymptomsInfection
2008
Role of Human Polyomaviruses in Respiratory Tract Disease in Young Children - Volume 14, Number 11—November 2008 - Emerging Infectious Diseases journal - CDC
Wattier RL, Vázquez M, Weibel C, Shapiro ED, Ferguson D, Landry ML, Kahn JS. Role of Human Polyomaviruses in Respiratory Tract Disease in Young Children - Volume 14, Number 11—November 2008 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2008, 14: 1766-1768. PMID: 18976566, PMCID: PMC2630739, DOI: 10.3201/eid1411.080394.Peer-Reviewed Original ResearchReal-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients
Landry ML, Cohen S, Ferguson D. Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients. Journal Of Clinical Virology 2008, 43: 148-151. PMID: 18639488, PMCID: PMC7173065, DOI: 10.1016/j.jcv.2008.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntibodies, MonoclonalChildChild, PreschoolFluorescent Antibody Technique, DirectHospitalizationHumansImmunoassayInfantInfluenza A virusInfluenza B virusInfluenza, HumanMiddle AgedNasopharynxReagent Kits, DiagnosticReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityTaq PolymeraseTime FactorsVirus CultivationYoung AdultConceptsHospitalized patientsTaqMan RT-PCRRT-PCRInfluenza ARapid flu testsDiagnosis of influenzaInfluenza-positive samplesDetection of influenzaReal-time RT-PCRInfluenza BInfluenza diagnosisPatient managementReal-time PCRMore accurate testsPatientsBinaxTrue positive samplesRapid testClinical samplesPositive samplesFurther studiesHospitalAccurate testInfluenzaDiagnosisProspective Study of Human Metapneumovirus Detection in Clinical Samples by Use of Light Diagnostics Direct Immunofluorescence Reagent and Real-Time PCR
Landry ML, Cohen S, Ferguson D. Prospective Study of Human Metapneumovirus Detection in Clinical Samples by Use of Light Diagnostics Direct Immunofluorescence Reagent and Real-Time PCR. Journal Of Clinical Microbiology 2008, 46: 1098-1100. PMID: 18184854, PMCID: PMC2268359, DOI: 10.1128/jcm.01926-07.Peer-Reviewed Original Research
2007
Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006
Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006. Clinical Infectious Diseases 2007, 45: 1120-1131. PMID: 17918073, PMCID: PMC2064001, DOI: 10.1086/522188.Peer-Reviewed Original ResearchConceptsAdenovirus infectionIntensive care unit staySolid organ transplantationChronic disease conditionsAdenovirus isolatesUnited States 2004Adenovirus-positive specimensRisk factor modelingTyping methodsUnit stayRisk factorsAntigenic presentationChronic diseasesGenotype prevalenceClinical dataOrgan transplantationSevere diseaseRecent transplantationBone marrowBlinded comparisonDisease severityMilitary traineesSequence typing methodInfectionCancer diagnosis
2006
Human Bocavirus Infection in Young Children in the United States: Molecular Epidemiological Profile and Clinical Characteristics of a Newly Emerging Respiratory Virus
Kesebir D, Vazquez M, Weibel C, Shapiro ED, Ferguson D, Landry ML, Kahn JS. Human Bocavirus Infection in Young Children in the United States: Molecular Epidemiological Profile and Clinical Characteristics of a Newly Emerging Respiratory Virus. The Journal Of Infectious Diseases 2006, 194: 1276-1282. PMID: 17041854, PMCID: PMC7204143, DOI: 10.1086/508213.Peer-Reviewed Original ResearchConceptsRespiratory tract diseasePolymerase chain reactionAsymptomatic childrenClinical characteristicsEpidemiological profileRespiratory specimensTract diseaseLower respiratory tract diseaseHBoV-positive childrenHuman bocavirus infectionRespiratory syncytial virusMolecular epidemiological profileYears of ageYoung childrenDiagnostic laboratoriesBocavirus infectionRespiratory specimenAbnormal findingsRespiratory virusesRespiratory secretionsSyncytial virusHuman bocavirusParainfluenza virusB virusChest radiographyCoronavirus HKU1 Infection in the United States - Volume 12, Number 5—May 2006 - Emerging Infectious Diseases journal - CDC
Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Coronavirus HKU1 Infection in the United States - Volume 12, Number 5—May 2006 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2006, 12: 775-779. PMID: 16704837, PMCID: PMC3374449, DOI: 10.3201/eid1205.051316.Peer-Reviewed Original ResearchConceptsHCoV-HKU1Respiratory specimensLower respiratory tract infectionsLower respiratory tract diseaseHCoV-HKU1 infectionRespiratory tract infectionsRespiratory syncytial virusRespiratory tract diseaseReverse transcription-polymerase chain reactionNew human coronavirusYears of ageTranscription-polymerase chain reactionTract infectionsSyncytial virusPositive childrenParainfluenza virusTract diseaseRespiratory tractHuman coronavirusesPositive specimensInfluenza virusInfectionChain reactionChildrenVirus
2005
Real-Time Nucleic Acid Sequence-Based Amplification Using Molecular Beacons for Detection of Enterovirus RNA in Clinical Specimens
Landry ML, Garner R, Ferguson D. Real-Time Nucleic Acid Sequence-Based Amplification Using Molecular Beacons for Detection of Enterovirus RNA in Clinical Specimens. Journal Of Clinical Microbiology 2005, 43: 3136-3139. PMID: 16000425, PMCID: PMC1169110, DOI: 10.1128/jcm.43.7.3136-3139.2005.Peer-Reviewed Original ResearchConceptsNucleic acid sequence-based amplificationTime Nucleic Acid Sequence-Based AmplificationEV-positive samplesReal-time nucleic acid sequence-based amplificationDetection of enterovirusesEnterovirus RNAStool samplesCerebrospinal fluidNASBA assayClinical specimensEnterovirusesMolecular beacon technologyAssaysDetection of Human Metapneumovirus in Clinical Samples by Immunofluorescence Staining of Shell Vial Centrifugation Cultures Prepared from Three Different Cell Lines
Landry ML, Ferguson D, Cohen S, Peret TC, Erdman DD. Detection of Human Metapneumovirus in Clinical Samples by Immunofluorescence Staining of Shell Vial Centrifugation Cultures Prepared from Three Different Cell Lines. Journal Of Clinical Microbiology 2005, 43: 1950-1952. PMID: 15815029, PMCID: PMC1081324, DOI: 10.1128/jcm.43.4.1950-1952.2005.Peer-Reviewed Original ResearchAssociation between a Novel Human Coronavirus and Kawasaki Disease
Esper F, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Association between a Novel Human Coronavirus and Kawasaki Disease. The Journal Of Infectious Diseases 2005, 191: 499-502. PMID: 15655771, PMCID: PMC7199489, DOI: 10.1086/428291.Peer-Reviewed Original ResearchConceptsKawasaki diseaseNovel human coronavirusRespiratory secretionsHuman coronavirusesClassic Kawasaki diseaseNew Haven coronavirusCase-control studyReverse transcriptase-polymerase chain reactionSystemic vasculitisControl subjectsPolymerase chain reactionPossible associationDiseaseChain reactionInfectionCoronavirusSecretionAssociationVasculitisInfantsEtiologyEvidence of a Novel Human Coronavirus That Is Associated with Respiratory Tract Disease in Infants and Young Children
Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Evidence of a Novel Human Coronavirus That Is Associated with Respiratory Tract Disease in Infants and Young Children. The Journal Of Infectious Diseases 2005, 191: 492-498. PMID: 15655770, PMCID: PMC7199485, DOI: 10.1086/428138.Peer-Reviewed Original ResearchConceptsRespiratory tract diseaseTract diseaseNovel human coronavirusHuman coronavirusesYoung childrenNew Haven coronavirusAbnormal breath soundsClinical featuresSymptomatic childrenPolymerase chain reactionRespiratory specimensRespiratory tractCommon findingBreath soundsAnimal CoVsHCoVsNew HavenDiseaseInfantsEtiological agentSubstantial proportionChain reactionChildrenSignificant proportionInfection
2004
Human Metapneumovirus and Severity of Respiratory Syncytial Virus Disease - Volume 10, Number 7—July 2004 - Emerging Infectious Diseases journal - CDC
Lazar I, Weibel C, Dziura J, Ferguson D, Landry ML, Kahn JS. Human Metapneumovirus and Severity of Respiratory Syncytial Virus Disease - Volume 10, Number 7—July 2004 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2004, 10: 1318-1320. PMID: 15324559, PMCID: PMC3323339, DOI: 10.3201/eid1007.030983.Peer-Reviewed Original ResearchA 1-Year Experience with Human Metapneumovirus in Children Aged <5 Years
Esper F, Martinello RA, Boucher D, Weibel C, Ferguson D, Landry ML, Kahn JS. A 1-Year Experience with Human Metapneumovirus in Children Aged <5 Years. The Journal Of Infectious Diseases 2004, 189: 1388-1396. PMID: 15073675, PMCID: PMC7109939, DOI: 10.1086/382482.Peer-Reviewed Original ResearchConceptsHuman metapneumovirusPresence of hMPVStudy periodHMPV-positive childrenRespiratory syncytial virusParainfluenza virus 1Respiratory tract diseaseReverse transcription-polymerase chain reactionDirect fluorescent antibody testFluorescent antibody testSyncytial virusRespiratory specimensPolymerase chain reactionChildren AgedCommon findingInfluenza ARespiratory pathogensChest wallAntibody testVirus 1Chain reactionNegative resultsMetapneumovirusSignificant proportionChildren