2024
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedonia
2020
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imaging
2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterationsA factor analytic evaluation of the World Health Organization Disability Assessment Schedule 2.0 among veterans presenting to a generalist mental health clinic
Sexton MB, Davis MT, Lusk RK, Lyubkin M, Chermack ST. A factor analytic evaluation of the World Health Organization Disability Assessment Schedule 2.0 among veterans presenting to a generalist mental health clinic. Psychiatry Research 2019, 272: 638-642. PMID: 30616134, DOI: 10.1016/j.psychres.2019.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory Care FacilitiesDiagnostic and Statistical Manual of Mental DisordersDisability EvaluationDisabled PersonsFactor Analysis, StatisticalFemaleHumansMaleMental HealthMental Health ServicesMiddle AgedSurveys and QuestionnairesUnited StatesVeteransWorld Health OrganizationYoung AdultConceptsWorld Health Organization Disability Assessment Schedule 2.0Disability Assessment Schedule 2.0WHODAS 2.0Veterans AffairsMental health clinicsU.S. veteran populationClinical decision makingVeterans Benefits AdministrationHealth clinicsVeteran populationMental disordersMental healthcareGlobal assessmentStatistical ManualFactor analytic evaluationVeteran sampleDSM-5Multiaxial systemVeteransFactor structureNon-clinical sampleFifth editionExploratory analysisGood model fitDiscontinuation
2017
A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure
Sexton MB, Davis MT, Bennett DC, Morris DH, Rauch SAM. A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure. Journal Of Affective Disorders 2017, 226: 232-238. PMID: 29017066, DOI: 10.1016/j.jad.2017.09.048.Peer-Reviewed Original ResearchConceptsPosttraumatic Cognitions InventoryMilitary sexual traumaPosttraumatic stress disorderTrauma-related beliefsMilitary trauma exposureTrauma-focused treatmentTrauma exposureFactor modelTrauma typesStress disorderSexual traumaCritical constructsSalient relationshipsMilitary traumaStress exposurePsychometric evaluationFactor scoresSubscale scoresReliability validityConfirmatory analysisStandard assessmentVeteransInventoryValidityTraumaPreliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures
Davis MT, DellaGioia N, Matuskey D, Harel B, Maruff P, Pietrzak RH, Esterlis I. Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures. Journal Of Affective Disorders 2017, 218: 82-85. PMID: 28460315, PMCID: PMC6457447, DOI: 10.1016/j.jad.2017.04.064.Peer-Reviewed Original ResearchConceptsCogState measuresVerbal learningComputerized cognitive test batteryLower full-scale IQ scoresFull Scale IQ scoresCognitive test batteryCognitive test performanceMajor depressive disorderMagnitude of deficitsVisual attentionVisual memoryCognitive measuresExecutive functionCognitive functioningPsychomotor speedVisuospatial problemIntellectual functioningIQ scoresTest batteryCognitive deficitsTest performanceCognitive dysfunctionMemoryAssessment measuresDepressive disorder
2015
The Posttraumatic Stress Disorder Checklist for DSM‐5 (PCL‐5): Development and Initial Psychometric Evaluation
Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL. The Posttraumatic Stress Disorder Checklist for DSM‐5 (PCL‐5): Development and Initial Psychometric Evaluation. Journal Of Traumatic Stress 2015, 28: 489-498. PMID: 26606250, DOI: 10.1002/jts.22059.Peer-Reviewed Original ResearchConceptsPosttraumatic Stress Disorder ChecklistPCL-5 scoresComparative fit indexPCL-5Initial psychometric evaluationPTSD symptomsTucker-Lewis indexDSM-5Trauma-exposed college studentsSelf-report measuresPsychometric evaluationStrong internal consistencyConfirmatory factor analysisDSM-5 changesTest-retest reliabilityPTSD criteriaStudy 1Study 2Sound measureDiscriminant validityPsychometric propertiesCollege studentsFit indicesAdequate fitSuperior fit
2014
PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide
Zuromski KL, Davis MT, Witte TK, Weathers F, Blevins C. PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide. Suicide And Life-Threatening Behavior 2014, 44: 682-697. PMID: 24796870, DOI: 10.1111/sltb.12098.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersPosttraumatic stress disorderAcquired CapabilitySpecific PTSD symptom clustersSymptom clustersTrauma-exposed undergraduatesInterpersonal-psychological theorySuicidal behaviorAnxious arousalPTSD symptomsStress disorderPain tolerancePrevious researchCurrent studySuicideNumbingObserved relationshipArousalRelationshipUndergraduatesConstructsBehaviorDisordersResearchSymptoms
2012
Quantifying the Relationship Between Perceived Consequences of ADHD Medication and Its Usage
Cox DJ, Davis MT, Cox BS, Burket RC, Merkel RL, Mikami AY, Ford D. Quantifying the Relationship Between Perceived Consequences of ADHD Medication and Its Usage. Journal Of Attention Disorders 2012, 19: 78-83. PMID: 22912505, DOI: 10.1177/1087054712452913.Peer-Reviewed Original Research