2020
RETREG1/FAM134B mediated autophagosomal degradation of AMFR/GP78 and OPA1 —a dual organellar turnover mechanism
Mookherjee D, Das S, Mukherjee R, Bera M, Jana S, Chakrabarti S, Chakrabarti O. RETREG1/FAM134B mediated autophagosomal degradation of AMFR/GP78 and OPA1 —a dual organellar turnover mechanism. Autophagy 2020, 17: 1729-1752. PMID: 32559118, PMCID: PMC8354597, DOI: 10.1080/15548627.2020.1783118.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagosomesCell Line, TumorChlorocebus aethiopsCOS CellsGene Knockdown TechniquesGTP PhosphohydrolasesHeLa CellsHumansIntracellular Signaling Peptides and ProteinsLysosomesMembrane ProteinsMicroscopy, ConfocalMicroscopy, Electron, TransmissionReal-Time Polymerase Chain ReactionReceptors, Autocrine Motility FactorConceptsInner mitochondrial membraneRETREG1/FAM134BEndoplasmic reticulumMitochondrial membraneFluorescent proteinAutophagosomal degradationOuter mitochondrial membrane proteinMahogunin Ring Finger-1OPA1 mitochondrial dynaminMicrotubule associated protein 1 light chain 3Outer mitochondrial membrane 20AMFR/gp78Cellular surveillance systemsMitochondrial membrane proteinInteresting new geneAutocrine motility factor receptorOuter mitochondrial membraneLC3-interacting regionMAP1LC3/LC3Protein 1 light chain 3Blue fluorescent proteinSQSTM1/p62Green fluorescent proteinRed fluorescent proteinReticulophagy regulator 1Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
Ramakrishnan S, Bera M, Coleman J, Rothman JE, Krishnakumar SS. Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis. ELife 2020, 9: e54506. PMID: 32401194, PMCID: PMC7220375, DOI: 10.7554/elife.54506.Peer-Reviewed Original ResearchConceptsSynaptotagmin-1Vesicular fusion machinerySingle-vesicle fusionFusion of vesiclesSNARE complexFusion machineryNeuronal exocytosisOligomer bindsRegulatory proteinsVesicle fusionSNAREpinsSynchronous fusionSynaptic vesiclesNovel mechanismVesiclesComplexinKinetic delayPrimary interfaceSynergistic roleFusionExocytosisMachineryProteinBindsMechanismNuclear filaments: role in chromosomal positioning and gene expression
Bera M, Sengupta K. Nuclear filaments: role in chromosomal positioning and gene expression. Nucleus 2020, 11: 99-110. PMID: 32453974, PMCID: PMC7529408, DOI: 10.1080/19491034.2020.1769445.Peer-Reviewed Original ResearchConceptsChromosomal contactsGene expressionLMNA mutationsInner nuclear membraneDNA damage repairGene expression profilesIntrachromosomal contactsChromosomal positioningChromosome positioningNuclear actinNuclear laminsEpigenetic modificationsLamin networkChromosomal loopsDamage repairExpression profilesNuclear membraneNuclear processesKey playersLaminsLaminopathiesMutationsElastic meshworkMuscle tissueMechanical rigidity
2019
Chromosome Territorial Organization Drives Efficient Protein Complex Formation: A Hypothesis.
Bera M, Kalyana Sundaram RV. Chromosome Territorial Organization Drives Efficient Protein Complex Formation: A Hypothesis. The Yale Journal Of Biology And Medicine 2019, 92: 541-548. PMID: 31543715, PMCID: PMC6747946.Peer-Reviewed Original ResearchConceptsProtein complex assemblyProtein complex formationNascent protein chainNuclear basketExport factorsProtein complexesComplex assemblyNuclear granulesKissing loopProtein chainsEukaryotesMRNAComplex formationComplex formation efficiencyChromosomesERPathwayAssemblyLoopInterphaseComplexesGranulesTranslationFormationExportSynaptotagmin oligomers are necessary and can be sufficient to form a Ca2+‐sensitive fusion clamp
Ramakrishnan S, Bera M, Coleman J, Krishnakumar SS, Pincet F, Rothman JE. Synaptotagmin oligomers are necessary and can be sufficient to form a Ca2+‐sensitive fusion clamp. FEBS Letters 2019, 593: 154-162. PMID: 30570144, PMCID: PMC6349546, DOI: 10.1002/1873-3468.13317.Peer-Reviewed Original Research