2008
Advances in Radiotherapy for Lung Cancer
Decker R, Wilson L. Advances in Radiotherapy for Lung Cancer. Seminars In Respiratory And Critical Care Medicine 2008, 29: 285-290. PMID: 18506666, DOI: 10.1055/s-2008-1076748.Peer-Reviewed Original ResearchConceptsLung cancerAggressive local therapyEarly lung tumorsProphylactic cranial irradiationPositron emission tomographic imagingDefinitive treatment optionCell lung cancerRole of radiosurgeryOngoing clinical investigationsEmission tomographic imagingNormal tissue toxicityCranial irradiationPalliative therapyPostoperative radiationLocal therapyLung irradiationAdvanced tumorsTreatment optionsCancer helpLung tumorsRadiation therapyClinical investigationRadiation treatment planningTissue toxicityTherapy
2000
Prognostic significance of cyclin D1 protein levels in early‐stage larynx cancer treated with primary radiation
Yoo S, Carter D, Turner B, Sasaki C, Son Y, Wilson L, Glazer P, Haffty B. Prognostic significance of cyclin D1 protein levels in early‐stage larynx cancer treated with primary radiation. International Journal Of Cancer 2000, 90: 22-28. PMID: 10725854, DOI: 10.1002/(sici)1097-0215(20000220)90:1<22::aid-ijc3>3.0.co;2-t.Peer-Reviewed Original ResearchConceptsEarly-stage larynx cancerLocal relapsePrognostic significanceLarynx cancerTotal median dosePrimary radiation therapySquamous cell carcinomaCell nuclear antigen levelsParaffin-embedded specimensSignificant clinical implicationsCase-control designPercent distributionLarynx cancer patientsCyclin D1 protein levelsCyclin D1 levelsMedian doseControl patientsLocal recurrenceAntigen levelsCancer patientsCell carcinomaDaily fractionsRadiation therapyIndex caseClinical informationPSA based review of adjuvant and salvage radiation therapy vs. observation in postoperative prostate cancer patients
Peschel R, Robnett T, Hesse D, King C, Ennis R, Schiff P, Wilson L. PSA based review of adjuvant and salvage radiation therapy vs. observation in postoperative prostate cancer patients. International Journal Of Cancer 2000, 90: 29-36. PMID: 10725855, DOI: 10.1002/(sici)1097-0215(20000220)90:1<29::aid-ijc4>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsPostoperative radiation therapyBNED survival ratesAdjuvant radiation therapyHigh-risk patientsSalvage radiation therapyPostoperative prostate cancer patientsProstate cancer patientsRadiation therapySurvival ratePSA levelsBiochemical failureCancer patientsBiochemical disease-free survival ratesHigh-risk surgery patientsDisease-free survival ratesAdjuvant radiation groupPreoperative PSA levelSeminal vesicle involvementEarly prostate cancerLife table methodAdjuvant settingSalvage radiationClinical recurrenceSurgery patientsClinical factors
1999
Evaluation of T-cell receptor gene rearrangements in patients with recurrent patch/plaque (T2) CTCL (mycosis fungoides).
Thayu M, Tallini G, Glusac E, Kacinski B, Wilson L. Evaluation of T-cell receptor gene rearrangements in patients with recurrent patch/plaque (T2) CTCL (mycosis fungoides). The Yale Journal Of Biology And Medicine 1999, 72: 365-75. PMID: 11138932, PMCID: PMC2579043.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedElectronsFemaleGene Rearrangement, T-LymphocyteHumansMaleMiddle AgedMycosis FungoidesNeoplasm Recurrence, LocalReceptors, Antigen, T-CellSkin NeoplasmsConceptsTotal skin electron beam therapyDisease-free intervalMycosis fungoidesPolymerase chain reactionSkin biopsiesMedian disease-free intervalCutaneous T-cell lymphomaT-cell receptor gene rearrangementsDominant TCR clonesT-cell receptor gamma gene rearrangementEvaluation of patientsTissue samplesIdentification of patientsT-cell lymphomaGene rearrangementsReceptor gene rearrangementsGamma gene rearrangementsRecurrent mycosis fungoidesElectron beam therapyDominant TCRMF patientsTCR analysisTCR clonesMalignant lymphocytesT lymphocytes
1998
Intraoperative brachytherapy, laryngopharyngoesophagectomy, and gastric transposition for patients with recurrent hypopharyngeal and cervical esophageal carcinoma
Wilson L, Chung J, Haffty B, Cahow E, Sasaki C, Son Y. Intraoperative brachytherapy, laryngopharyngoesophagectomy, and gastric transposition for patients with recurrent hypopharyngeal and cervical esophageal carcinoma. The Laryngoscope 1998, 108: 1504-1508. PMID: 9778290, DOI: 10.1097/00005537-199810000-00014.Peer-Reviewed Original ResearchConceptsExternal beam radiationGastric transpositionCervical esophagusLocal controlMedian doseRecurrent carcinomaActuarial local controlCervical esophageal carcinomaLymphvascular space invasionTotal median doseLymph node dissectionGood local controlAcceptable risk profileActuarial survivalNode dissectionFacial painNodal involvementOverall survivalRecurrent diseaseCervical abscessIntraoperative brachytherapyMale patientsMedian ageMucosal hemorrhageFacial edemaEffective Treatment of Stage I Uterine Papillary Serous Carcinoma with High Dose-Rate Vaginal Apex Radiation (192Ir) and Chemotherapy
Turner B, Knisely J, Kacinski B, Haffty B, Gumbs A, Roberts K, Frank A, Peschel R, Rutherford T, Edraki B, Kohorn E, Chambers S, Schwartz P, Wilson L. Effective Treatment of Stage I Uterine Papillary Serous Carcinoma with High Dose-Rate Vaginal Apex Radiation (192Ir) and Chemotherapy. International Journal Of Radiation Oncology • Biology • Physics 1998, 40: 77-84. PMID: 9422561, DOI: 10.1016/s0360-3016(97)00581-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBrachytherapyChemotherapy, AdjuvantCystadenocarcinoma, PapillaryDisease-Free SurvivalFemaleHumansHysterectomyMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesSalvage TherapyUterine NeoplasmsConceptsUterine papillary serous carcinomaWhole pelvic radiation therapyWhole-abdomen radiation therapyComplete surgical stagingDisease-free survivalActuarial disease-free survivalFIGO stage IPapillary serous carcinomaSurgical stagingActuarial OSOverall survivalSalvage rateStage IRadiation therapyUPSC patientsVaginal brachytherapyMyometrial invasionSerous carcinomaLDR brachytherapyRadiation Therapy Oncology Group (RTOG) grade 1DFS of patientsPara-aortic lymph node samplingConventional external beam radiotherapyFIGO stage IARTOG grade 3
1997
Treatment of recurrent pelvic and selected primary gynecologic malignancies with 241Am
Chung J, Roberts K, Peschel R, Nath R, Pourang R, Kacinski B, Wilson L. Treatment of recurrent pelvic and selected primary gynecologic malignancies with 241Am. International Journal Of Cancer 1997, 5: 227-234. PMID: 9372545, DOI: 10.1002/(sici)1520-6823(1997)5:5<227::aid-roi3>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsRecurrent pelvic malignanciesPrimary gynecologic malignanciesPrimary radiotherapySurgical salvageMicroscopic diseasePelvic malignanciesPostoperative radiotherapyGynecologic malignanciesUltimate local control rateExternal beam radiation therapyGross primary tumorMedian patient ageLocal control rateTreatment of recurrentBeam radiation therapyMicroscopic residuumTreatment intentPatient ageSurgical resectionCurative therapyGynecologic tumorsGynecologic cancerControl ratePrimary tumorRadiation therapy
1996
Additional courses of total skin electron beam therapy in the treatment of patients with recurrent cutaneous T-cell lymphoma
Wilson L, Quiros P, Kolenik S, Heald P, Braverman I, Edelson R, Kacinski B. Additional courses of total skin electron beam therapy in the treatment of patients with recurrent cutaneous T-cell lymphoma. Journal Of The American Academy Of Dermatology 1996, 35: 69-73. PMID: 8682967, DOI: 10.1016/s0190-9622(96)90499-5.Peer-Reviewed Original ResearchConceptsTotal skin electron beam therapyCutaneous T-cell lymphomaRecurrent cutaneous T-cell lymphomaComplete responseT-cell lymphomaElectron beam therapySecond courseMedian disease-free intervalThird courseAdditional coursesBeam therapyDisease-free intervalTreatment of patientsAcceptable risk profileForm of therapyMedian doseMedian survivalMild erythemaPatientsInitial courseTherapyVariety of modalitiesRisk profileEntire groupLocalized radiationExtent of skin involvement as a prognostic indicator of disease free and overall survival of patients with T3 cutaneous T‐cell lymphoma treated with total skin electron beam radiation therapy
Quiros P, Kacinski B, Wilson L. Extent of skin involvement as a prognostic indicator of disease free and overall survival of patients with T3 cutaneous T‐cell lymphoma treated with total skin electron beam radiation therapy. Cancer 1996, 77: 1912-1917. PMID: 8646693, DOI: 10.1002/(sici)1097-0142(19960501)77:9<1912::aid-cncr23>3.0.co;2-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBody Surface AreaChemotherapy, AdjuvantCohort StudiesDisease-Free SurvivalFemaleFollow-Up StudiesHumansLymphoma, T-Cell, CutaneousMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRadiotherapy DosageRadiotherapy, High-EnergyRemission InductionRetrospective StudiesSkinSkin NeoplasmsSurvival RateConceptsTotal skin electron beam therapyCutaneous T-cell lymphomaComplete clinical responseOverall survivalSkin involvementT-cell lymphomaMedian DFSPrognostic indicatorTotal skin electron beam radiation therapyToxicity of therapyElectron beam radiation therapyBeam radiation therapyTotal skin surfaceElectron beam therapyFree survivalClinical responsePrognostic significanceTumor nodulesRadiation therapyPatientsPatient recordsTherapyDiseaseBeam therapyMonths
1995
Subareolar breast cancer: Long-term results with conservative surgery and radiation therapy
Haffty B, Wilson L, Smith R, Fischer D, Beinfield M, Ward B, McKhann C. Subareolar breast cancer: Long-term results with conservative surgery and radiation therapy. International Journal Of Radiation Oncology • Biology • Physics 1995, 33: 53-57. PMID: 7642431, DOI: 10.1016/0360-3016(95)00165-u.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCombined Modality TherapyFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm Recurrence, LocalNipplesPrognosisRetrospective StudiesTreatment OutcomeConceptsEntire nipple areolar complexSubareolar breast cancersNipple-areolar complexEarly-stage breast cancerMajority of patientsStage breast cancerAreolar complexBreast cancerConservative surgeryRadiation therapyMedian doseConservative managementRelative contraindicationAxillary lymph node dissectionDistant disease-free survivalYale-New Haven HospitalTotal median doseAdjuvant systemic therapyLymph node dissectionRegional nodal irradiationDisease-free survivalRecurrence-free survivalSubset of patientsTime of surgeryLong-term results
1994
Adjuvant systemic chemotherapy and hormonal therapy. Effect on local recurrence in the conservatively treated breast cancer patient
Haffty B, Wilmarth L, Wilson L, Fischer D, Beinfield M, McKhann C. Adjuvant systemic chemotherapy and hormonal therapy. Effect on local recurrence in the conservatively treated breast cancer patient. Cancer 1994, 73: 2543-2548. PMID: 8174051, DOI: 10.1002/1097-0142(19940515)73:10<2543::aid-cncr2820731015>3.0.co;2-7.Peer-Reviewed Original ResearchConceptsAdjuvant systemic therapyAdjuvant systemic chemotherapyLower relapse rateMajority of patientsSystemic therapySystemic chemotherapyRadiation therapyBreast relapseHormonal therapyLymph nodesRelapse rateSignificant independent prognostic factorAdjuvant hormonal therapyNegative lymph nodesCox regression analysisIndependent prognostic factorBreast cancer patientsAxillary dissectionLocal relapseLocal recurrencePatient agePrognostic factorsCancer patientsRetrospective analysisIntact breast
1993
Conservative surgery and radiation in the treatment of synchronous ipsilateral breast cancers
Wilson L, Beinfield M, McKhann C, Haffty B. Conservative surgery and radiation in the treatment of synchronous ipsilateral breast cancers. Cancer 1993, 72: 137-142. PMID: 8389664, DOI: 10.1002/1097-0142(19930701)72:1<137::aid-cncr2820720126>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsIpsilateral breast cancerConservative surgeryRadiation therapyRecurrence rateBreast cancerBreast recurrence rateChest wall progressionIpsilateral breast recurrenceActuarial survival rateEvidence of diseaseLocal recurrence rateManagement of patientsSubsequent local recurrenceInvasive lobular histologyBreast recurrenceLobular histologyMedian doseMetastatic diseaseLocal recurrenceThird patientRegional lymphaticsSeparate lesionsSingle lesionSame breastPatients