2024
Strategies to Deimplement Opioid Prescribing in Primary Care
Quanbeck A, Robinson J, Jacobson N, Li X, Hennessy-Garza R, Landeck J, Cohen A, Madden L, Pulvermacher A, Brown R. Strategies to Deimplement Opioid Prescribing in Primary Care. JAMA Network Open 2024, 7: e2438325. PMID: 39388183, PMCID: PMC11581553, DOI: 10.1001/jamanetworkopen.2024.38325.Peer-Reviewed Original ResearchConceptsCluster randomized clinical trialDeimplementation strategiesMorphine milligram equivalent doseMorphine milligram equivalentsPractice facilitationOpioid prescribingIncreased screeningTreatment agreementsUS health care systemCenters for Disease Control and Prevention guidelinesRandomized clinical trialsUrine drug screensPrimary care clinicsPrimary care settingPrimary outcomeMental health screeningPain-related interferenceHealth care systemHigh-intensity groupEnjoyment of lifeChronic pain managementPrimary careCare clinicsCare settingsHealth screening
2021
Psychiatric comorbidity and order of condition onset among patients seeking treatment for chronic pain and opioid use disorder
Barry DT, Beitel M, Cutter CJ, Fiellin DA, Madden LM, Lipkind N, Bollampally P, Liong C, Schottenfeld RS. Psychiatric comorbidity and order of condition onset among patients seeking treatment for chronic pain and opioid use disorder. Drug And Alcohol Dependence 2021, 221: 108608. PMID: 33667784, PMCID: PMC8026725, DOI: 10.1016/j.drugalcdep.2021.108608.Peer-Reviewed Original ResearchConceptsOpioid use disorderChronic painPsychiatric comorbidityCondition onsetUse disordersNonopioid substance use disordersDSM-IV-TR Axis I DisordersFirst groupComorbid chronic painStructured Clinical InterviewAxis I DisordersAxis II disordersSubstance use disordersDSM-IV personality disordersStandardized training protocolSame time groupsPotential treatment implicationsClinical trialsDoctoral-level providersI disordersMultinomial logistic regressionPrimary drugClinical InterviewPainDiagnostic Interview
2020
A qualitative investigation of addiction counselors' perceptions and experiences implementing an open-access model for treating opioid use disorder
Oberleitner LMS, Madden LM, Muthulingam D, Marcus R, Oberleitner DE, Beitel M, Gaeta M, Tamberelli JF, Barry DT. A qualitative investigation of addiction counselors' perceptions and experiences implementing an open-access model for treating opioid use disorder. Journal Of Substance Use And Addiction Treatment 2020, 121: 108191. PMID: 33357602, PMCID: PMC7770334, DOI: 10.1016/j.jsat.2020.108191.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentTreatment programOpioid treatment programsOpioid use disorderMaintenance treatmentTreatment optionsMethadone maintenanceUse disordersProspective patientsIndividual semi-structured interviewsCounselors' perceptionsTreatment organizationsInterdisciplinary teamCliniciansAddiction counselorsSemi-structured interviewsCorrelates of Homelessness Among Patients in Methadone Maintenance Treatment
Gaeta M, Beitel M, Oberleitner LMS, Oberleitner DE, Madden LM, Tamberelli JF, Barry DT. Correlates of Homelessness Among Patients in Methadone Maintenance Treatment. Medical Care 2020, 58: 1030-1034. PMID: 32925463, PMCID: PMC7668351, DOI: 10.1097/mlr.0000000000001414.Peer-Reviewed Original ResearchConceptsOpioid use disorderImportant public health roleLogistic regressionMethadone maintenance treatment programImportant public health issueTreatment-related correlatesCorrelates of homelessnessPercent of patientsMethadone maintenance treatmentFinal logistic regression modelMaintenance treatment programPublic health roleSymptoms of depressionBivariate logistic regressionPublic health issueLogistic regression modelsMaintenance treatmentUse disordersPatientsSignificant independent variablesHealth roleBivariate analysisTreatment programPast monthHigher symptomsThe real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine
Farnum SO, Makarenko I, Madden L, Mazhnaya A, Marcus R, Prokhorova T, Bojko MJ, Rozanova J, Dvoriak S, Islam Z, Altice FL. The real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine. Addiction 2020, 116: 83-93. PMID: 32428276, PMCID: PMC7674222, DOI: 10.1111/add.15115.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOAT discontinuationAgonist therapyTreatment retentionIndependent predictorsHIV epidemicCost-effective HIV prevention strategyMethadone maintenance treatment patientsObservational longitudinal cohort studySpecialty addictions treatmentBuprenorphine maintenance treatmentHigh dosageHIV prevention strategiesLongitudinal cohort studyOpioid-dependent peopleTreatment discontinuationCohort studyMaintenance treatmentMale sexTreatment patientsPrevention strategiesDiscontinuationYounger ageCenter settingAddiction treatmentCorrelates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment
Baldassarri SR, Beitel M, Zinchuk A, Redeker NS, Oberleitner DE, Oberleitner LMS, Carrasco D, Madden LM, Lipkind N, Fiellin DA, Bastian LA, Chen K, Yaggi HK, Barry DT. Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment. Sleep And Breathing 2020, 24: 1729-1737. PMID: 32556918, PMCID: PMC7680294, DOI: 10.1007/s11325-020-02123-z.Peer-Reviewed Original ResearchConceptsOpioid use disorderExcessive daytime sleepinessDaytime sleepinessSleep qualityChronic painExcessive daytimeUse disordersConclusionsPoor sleep qualityCurrent chronic painModifiable risk factorsImpaired sleep qualityMultivariable linear regression modelsBody mass indexPoor sleep qualityNon-significant associationMass indexMultivariable analysisPain interferenceRelated comorbiditiesMethadone treatmentClinical correlatesMean PSQIRisk factorsSleep disordersResultsNinety percentWomen’s Decision-Making about PrEP for HIV Prevention in Drug Treatment Contexts
Qin Y, Price C, Rutledge R, Puglisi L, Madden LM, Meyer JP. Women’s Decision-Making about PrEP for HIV Prevention in Drug Treatment Contexts. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2020, 19: 2325958219900091. PMID: 31918605, PMCID: PMC7099671, DOI: 10.1177/2325958219900091.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug treatment centersHIV preventionTreatment centersPre-exposure prophylaxis efficacyOwn HIV riskDrug treatment contextIntervenable targetPrEP interventionsPrEP awarenessProphylaxis efficacyHIV riskEarly recoveryUse disordersPrEPWomenPreventionTreatment contextSemistructured interviewsEfficacyRiskWomen's abilityLong-term systemic changesWomen's lackDecision-making skills
2019
Pain catastrophizing and pain acceptance are associated with pain severity and interference among methadone‐maintained patients
Mun CJ, Beitel M, Oberleitner L, Oberleitner DE, Madden LM, Bollampally P, Barry DT. Pain catastrophizing and pain acceptance are associated with pain severity and interference among methadone‐maintained patients. Journal Of Clinical Psychology 2019, 75: 2233-2247. PMID: 31454081, PMCID: PMC7213971, DOI: 10.1002/jclp.22842.Peer-Reviewed Original ResearchConceptsOpioid use disorderMethadone maintenance treatmentPain severityPain acceptanceChronic painPain interferenceMMT patientsUse disordersCo-occurring opioid use disorderMethadone-maintained patientsMethadone doseImportant intervention targetMaintenance treatmentPain catastrophizingPainPsychosocial interventionsPatientsIntervention targetsPrevious weekSeverityEmotional distressImportant targetSelf-report measuresDisordersPresent studyPhysicians’ satisfaction with providing buprenorphine treatment
Knudsen HK, Brown R, Jacobson N, Horst J, Kim JS, Collier E, Starr S, Madden LM, Haram E, Toy A, Molfenter T. Physicians’ satisfaction with providing buprenorphine treatment. Addiction Science & Clinical Practice 2019, 14: 34. PMID: 31446893, PMCID: PMC6709557, DOI: 10.1186/s13722-019-0163-3.Peer-Reviewed Original ResearchConceptsBuprenorphine treatmentBaseline Web-based surveyOpioid use disorderGeneral medical practiceStudy of physiciansMedical practiceWaivered physiciansTreatment recommendationsClinical trialsRisk factorsOpioid epidemicImportant treatmentMethodsAs partUse disordersWeb-based surveyPhysician job satisfactionPhysiciansTreatment organizationsBuprenorphineSignificant differencesTreatmentOverall satisfactionSatisfaction itemsStudy measuresLower satisfactionUsing nominal group technique to identify barriers, facilitators, and preferences among patients seeking treatment for opioid use disorder: A needs assessment for decision making support
Muthulingam D, Bia J, Madden LM, Farnum SO, Barry DT, Altice FL. Using nominal group technique to identify barriers, facilitators, and preferences among patients seeking treatment for opioid use disorder: A needs assessment for decision making support. Journal Of Substance Use And Addiction Treatment 2019, 100: 18-28. PMID: 30898324, PMCID: PMC6432946, DOI: 10.1016/j.jsat.2019.01.019.Peer-Reviewed Original ResearchConceptsOpioid use disorderNominal group techniquePharmacologic therapyUse disordersSyringe exchange programsIndividual-level barriersEvidence-based interventionsAddiction treatment centersEvidence-based strategiesOUD treatmentPharmacologic treatmentSpecific medicationsTreatment optionsPharmacologic propertiesMedicationsDecision aidPatient considerationsSide effectsTreatment centersOpioid crisisSpecific knowledge gapsGroup techniqueDecision aid developmentTreatmentTherapyElectronic cigarette and tobacco use in individuals entering methadone or buprenorphine treatment
Baldassarri SR, Fiellin DA, Savage ME, Madden LM, Beitel M, Dhingra LK, Fucito L, Camenga D, Bollampally P, Barry DT. Electronic cigarette and tobacco use in individuals entering methadone or buprenorphine treatment. Drug And Alcohol Dependence 2019, 197: 37-41. PMID: 30769264, PMCID: PMC6637405, DOI: 10.1016/j.drugalcdep.2018.12.012.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid agonist therapyCurrent cigarette smokingCigarette smokingEC useHigher oddsFormer smokersLower oddsPsychiatric distressPast cigarette smokingElectronic cigarette useAgonist therapyCurrent smokersBuprenorphine treatmentChronic painTobacco useNicotine dependenceUse disordersSmokingCigarette useMultivariate analysisElectronic cigarettesSmokersCigarettesMultivariate model
2018
An evaluation of the feasibility, acceptability, and preliminary efficacy of cognitive-behavioral therapy for opioid use disorder and chronic pain
Barry DT, Beitel M, Cutter CJ, Fiellin DA, Kerns RD, Moore BA, Oberleitner L, Madden LM, Liong C, Ginn J, Schottenfeld RS. An evaluation of the feasibility, acceptability, and preliminary efficacy of cognitive-behavioral therapy for opioid use disorder and chronic pain. Drug And Alcohol Dependence 2018, 194: 460-467. PMID: 30508769, PMCID: PMC6312460, DOI: 10.1016/j.drugalcdep.2018.10.015.Peer-Reviewed Original ResearchConceptsOpioid use disorderCognitive behavioral therapyChronic painPreliminary efficacyDrug counselingUse disordersImproved pain outcomesProportion of patientsMethadone-maintained patientsNonmedical opioid useEnd of treatmentPrimary study aimPatient satisfaction ratingsManualized cognitive behavioral therapyOpioid usePain outcomesPain interferenceClinical trialsStandard drug counselingPatientsMean sessionSecondary aimStudy aimPainPilot studyAssessment of barrier severity and willingness to enter opioid agonist treatment among people who inject drugs in Ukraine
Zelenev A, Shea P, Mazhnaya A, Rozanova J, Madden L, Marcus R, Altice FL. Assessment of barrier severity and willingness to enter opioid agonist treatment among people who inject drugs in Ukraine. Drug And Alcohol Dependence 2018, 190: 82-88. PMID: 29990648, PMCID: PMC6292439, DOI: 10.1016/j.drugalcdep.2018.05.027.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOpioid agonist treatmentOpioid-dependent peopleSubstance abuse treatment programsCross-sectional surveyAgonist therapyAgonist treatmentHIV preventionTreatment perceptionsTreatment efficacyOAT expansionStudy participantsTreatment programAddiction treatmentComposite measureSeveritySocial stigmaDrugsTreatmentStructural barriersBarrier severityParticipantsExperiences of Burnout among Drug Counselors in A Large Opioid Treatment Program: A Qualitative Investigation
Beitel M, Oberleitner L, Muthulingam D, Oberleitner D, Madden LM, Marcus R, Eller A, Bono MH, Barry DT. Experiences of Burnout among Drug Counselors in A Large Opioid Treatment Program: A Qualitative Investigation. Substance Use & Addiction Journal 2018, 39: 211-217. PMID: 29522381, DOI: 10.1080/08897077.2018.1449051.Peer-Reviewed Original ResearchConceptsExperience of burnoutDrug counselorsTreatment programJob-related demandsIndividual semi-structured interviewsWork engagementCounselor burnoutBurnoutCounselor feedbackPhysiological symptomsSemi-structured interviewsCounselorsQualitative investigationParticipantsPossible experienceSystem-level changesCounselor descriptionsExperienceProgram settingsOpioid treatment programsTreatment gapMultidisciplinary teamEngagementProgramTranscribedAn investigation of an open‐access model for scaling up methadone maintenance treatment
Madden LM, Farnum SO, Eggert KF, Quanbeck AR, Freeman RM, Ball SA, Schottenfeld RS, Shi JM, Savage ME, Barry DT. An investigation of an open‐access model for scaling up methadone maintenance treatment. Addiction 2018, 113: 1450-1458. PMID: 29453891, DOI: 10.1111/add.14198.Peer-Reviewed Original ResearchConceptsNon-medical opioid useOpioid use disorderMethadone maintenance treatmentOpioid useMaintenance treatmentTreatment accessUse disordersTreatment modelMethadone maintenance treatment centersMaintenance treatment centersDeleterious effectsMethadone treatmentPatient mortalityTreatment optionsTreatment outcomesTreatment centersProspective patientsRate of retentionPatient censusRapid enrollmentAddiction treatmentApparent deleterious effectsTreatmentMortalityProgrammatic outcomesHIV Risk perception and eligibility for pre-exposure prophylaxis in women involved in the criminal justice system
Rutledge R, Madden L, Ogbuagu O, Meyer JP. HIV Risk perception and eligibility for pre-exposure prophylaxis in women involved in the criminal justice system. AIDS Care 2018, 30: 1282-1289. PMID: 29527934, PMCID: PMC6085161, DOI: 10.1080/09540121.2018.1447079.Peer-Reviewed Original ResearchConceptsPrEP implementation programsPre-exposure prophylaxisHIV risk behaviorsPrEP awarenessHIV pre-exposure prophylaxisRisk behaviorsPersonal HIV riskPrEP care continuumPrEP-eligible womenHepatitis C infectionPrimary care providersHIV risk perceptionUnsafe injection practicesMeeting eligibility criteriaPrison/jailCross-sectional surveyRecent transactional sexLifetime substance usePrEP eligibleC infectionEligible womenCare continuumHIV riskCare providersHigh risk
2017
Drug Counselor Responses to Patients’ Pain Reports: A Qualitative Investigation of Barriers and Facilitators to Treating Patients with Chronic Pain in Methadone Maintenance Treatment
Beitel M, Oberleitner L, Kahn M, Kerns RD, Liong C, Madden LM, Ginn J, Barry DT. Drug Counselor Responses to Patients’ Pain Reports: A Qualitative Investigation of Barriers and Facilitators to Treating Patients with Chronic Pain in Methadone Maintenance Treatment. Pain Medicine 2017, 18: 2152-2161. PMID: 28177509, DOI: 10.1093/pm/pnw327.Peer-Reviewed Original ResearchConceptsOpioid use disorderMethadone maintenance treatmentChronic painDrug counselorsMaintenance treatmentTreatment needsUse disordersMedical providersCo-occurring chronic painMethadone maintenance treatment programPain management referralsChronic noncancer painPatient-related barriersMethadone-maintained patientsTreatment of patientsMaintenance treatment programPatients' treatment needsNoncancer painMedication regimensPain managementManagement referralsTreatment adherencePatient improvementPatient reportsPainCorrelates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment
Shrestha R, Karki P, Altice FL, Huedo-Medina TB, Meyer JP, Madden L, Copenhaver M. Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment. Drug And Alcohol Dependence 2017, 173: 107-116. PMID: 28214391, PMCID: PMC5366273, DOI: 10.1016/j.drugalcdep.2016.12.023.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisHIV risk reductionDrug injectionHIV riskRisk behaviorsHigh-risk drug usersHigh-risk PWUDOpioid-dependent personsHIV prevention approachesRecent risk behaviorsCross-sectional studyConsistent condom useHigh-risk behaviorsRisk reductionCorrelates of willingnessPrEP deliveryMethadone treatmentIndependent correlatesMethadone programsSafe drugElevated riskCasual partnersNeurocognitive impairmentDrug usersKey populations
2016
Physical activity, psychiatric distress, and interest in exercise group participation among individuals seeking methadone maintenance treatment with and without chronic pain
Beitel M, Stults-Kolehmainen M, Cutter CJ, Schottenfeld RS, Eggert K, Madden LM, Kerns RD, Liong C, Ginn J, Barry DT. Physical activity, psychiatric distress, and interest in exercise group participation among individuals seeking methadone maintenance treatment with and without chronic pain. American Journal On Addictions 2016, 25: 125-131. PMID: 26824197, DOI: 10.1111/ajad.12336.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentPhysical activity levelsExercise group participationChronic painPhysical activityPsychiatric distressMaintenance treatmentActivity levelsPast weekVigorous-intensity physical activityExercise of patientsIntensity physical activityExercise groupExercise interventionPainBrief self-report instrumentPatientsLow levelsSelf-report instrumentDistressWeeksDepressionTreatmentGroup participationParticipants