2024
Insights From Omics in Lyme Disease
Bockenstedt L, Belperron A. Insights From Omics in Lyme Disease. The Journal Of Infectious Diseases 2024, 230: s18-s26. PMID: 39140719, DOI: 10.1093/infdis/jiae250.Peer-Reviewed Original Research
2022
Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection
Boada P, Fatou B, Belperron A, Sigdel T, Smolen K, Wurie Z, Levy O, Ronca S, Murray K, Liberto J, Rashmi P, Kerwin M, Montgomery R, Bockenstedt L, Steen H, Sarwal M. Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection. Frontiers In Immunology 2022, 13: 1012824. PMID: 36569838, PMCID: PMC9784464, DOI: 10.3389/fimmu.2022.1012824.Peer-Reviewed Original ResearchConceptsWest Nile virus infectionLyme diseaseVirus infectionWNV infectionSerum proteomeSymptomatic WNV infectionTime of diagnosisHealthy control seraDisseminated Lyme diseaseHost response pathwaysExtracellular bacterial infectionsSerum proteomic analysisIntracellular viral infectionsViral infectionHost responseBacterial infectionsControl seraStudy participantsInfectionDiseaseDisease biomarkersEarly diagnosticsLC/MSMolecular mechanismsRecovery phase
2011
Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly
Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR. Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2011, 11: 104-110. PMID: 22023165, PMCID: PMC3257374, DOI: 10.1111/j.1474-9726.2011.00759.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingExtracellular Signal-Regulated MAP KinasesFemaleHumansInflammationInterleukin-8MaleMiddle AgedMonocytesMultivariate AnalysisNF-kappa BP38 Mitogen-Activated Protein KinasesPhosphorylationProtein TransportRNA, MessengerSignal TransductionToll-Like Receptor 5Tumor Necrosis Factor-alphaConceptsToll-like receptorsIL-8Multivariable mixed-effects modelsOlder individualsElevated IL-8Levels of TLR5Expression of TLR5Production of TNFAge-associated elevationAge-related decreaseDendritic cellsImmune responsivenessElderly donorsInflammatory responseImmune functionNF-κBTLR5Progressive declineMonocytesMixed effects modelsMAPK p38Significant increaseEffects modelAssociated increaseCritical mechanism
1988
Serial assessment of glomerular filtration rate in lupus nephropathy
Petri M, Bockenstedt L, Colman J, Whiting-O'Keefe Q, Fitz G, Sebastian A, Hellmann D. Serial assessment of glomerular filtration rate in lupus nephropathy. Kidney International 1988, 34: 832-839. PMID: 3210545, DOI: 10.1038/ki.1988.257.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateCreatinine clearanceLupus nephropathyFiltration rateIndividual patientsMeasurements of CCrSerial creatinine clearancesTrue glomerular filtration rateMagnitude of changeSerial assessmentInulin clearanceRenal clearanceSerial measurementsPatientsNephropathyCINClearanceOne-half
1987
The Activation of T Lymphocytes
Bockenstedt L, Goldsmith M, Koretzky G, Weiss A. The Activation of T Lymphocytes. Rheumatic Disease Clinics Of North America 1987, 13: 411-430. PMID: 2963355, DOI: 10.1016/s0889-857x(21)00926-1.Peer-Reviewed Original ResearchConceptsSignal transductionSecond messengerCD3/Ti complexSpecific cell surface receptorsCD3/TiIntracellular second messengerCell surface receptorsCellular genesActivation of PKCCell surface moleculesCellular responsesInteraction of ligandsBiochemical studiesCell surfaceSurface receptorsIntracellular eventsT cell activationPI metabolismAntigen-induced activationTransductionSurface moleculesMessengerCell activationComplex resultsActivation
1980
Constituents of Human Neutrophils that Mediate Enhanced Adherence to Surfaces
Bockenstedt L, Goetzl E. Constituents of Human Neutrophils that Mediate Enhanced Adherence to Surfaces. Journal Of Clinical Investigation 1980, 65: 1372-1381. PMID: 6251111, PMCID: PMC371475, DOI: 10.1172/jci109801.Peer-Reviewed Original ResearchConceptsHuman neutrophilsBasic amino acids lysineAcidic proteinSpecific granulesChemotactic inhibitory activityInvolvement of neutrophilsAmino acid lysineDose-response relationshipWT activityGlycerol gradientsAmino acidsEndogenous constituentsChemokinetic activityComparable dose-response relationshipsSubcellular fractionsNeutrophilsFactor IAspartic acidNeutrophil sonicatesSheep erythrocytesIsoelectric pointProteinChemotactic migrationGlutamic acidAdherence