2016
Palmoplantar Keratoderma in Costello Syndrome Responsive to Acitretin
Marukian NV, Levinsohn JL, Craiglow BG, Milstone LM, Choate KA. Palmoplantar Keratoderma in Costello Syndrome Responsive to Acitretin. Pediatric Dermatology 2016, 34: 160-162. PMID: 28008647, DOI: 10.1111/pde.13057.Peer-Reviewed Original ResearchConceptsCostello syndromePalmoplantar keratodermaCoarse facial featuresMultisystem congenital disorderSevere palmoplantar keratodermaDermatologic findingsAcanthosis nigricansKeratosis pilarisSystemic administrationSevere casesCardiac defectsCutaneous papillomasSkin redundancyCongenital disorderIntellectual disabilityAcitretinFunctional consequencesKeratodermaPatientsMalignancyPapillomasPilarisSyndromeAdministrationFacial features
1994
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-1137. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.Peer-Reviewed Original ResearchConceptsFollicle developmentTransgenic miceHair follicle developmentHuman keratin 14 promoterParathyroid hormone-related proteinNormal hair follicle developmentOverexpression of PTHrPHormone-related proteinHormone-related peptideKeratin 14 promoterHumoral hypercalcemiaPTHrP geneNormal tissuesMicePTHrPSkinOverexpressionCellular differentiationEarly stagesHypercalcemiaMalignancySyndromePeptidesFollicles
1989
Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties.
Insogna KL, Stewart AF, Morris CA, Hough LM, Milstone LM, Centrella M. Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties. Journal Of Clinical Investigation 1989, 83: 1057-1060. PMID: 2537846, PMCID: PMC303783, DOI: 10.1172/jci113947.Peer-Reviewed Original ResearchConceptsGrowth factor-like propertiesParathyroid hormone-like proteinHormone-like proteinNRK-49F cellsParaneoplastic syndromeHumoral hypercalcemiaLatter hormoneHuman tumorsPhysiological actionsPTHHuman dermal fibroblastsSignificant increaseSoft agarDisplay actionsDermal fibroblastsSynthetic peptidesSynthetic analoguesHypercalcemiaMalignancySyndromeTumorsUnique primary structure
1988
Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.
Mangin M, Webb A, Dreyer B, Posillico J, Ikeda K, Weir E, Stewart A, Bander N, Milstone L, Barton D. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 597-601. PMID: 2829195, PMCID: PMC279598, DOI: 10.1073/pnas.85.2.597.Peer-Reviewed Original ResearchConceptsParathyroid hormone-like peptideHumoral hypercalcemiaHormone-like peptideCommon paraneoplastic syndromeTumor-derived peptidesHuman renal carcinomaParaneoplastic syndromeNormal human keratinocytesHuman PTHRenal carcinomaHuman tumorsSyndromeHuman keratinocytesHypercalcemiaMalignancyBlot analysisTumorsRNA blot hybridization analysisPartial N-terminal amino acid sequencePeptidesMRNABlot hybridization analysisMature peptideCarcinomaPTH
1986
A Parathyroid Hormone-Like Protein from Cultured Human Keratinocytes
Merendino JJ, Insogna KL, Milstone LM, Broadus AE, Stewart AF. A Parathyroid Hormone-Like Protein from Cultured Human Keratinocytes. Science 1986, 231: 388-390. PMID: 2417317, DOI: 10.1126/science.2417317.Peer-Reviewed Original ResearchConceptsHumoral hypercalcemiaParathyroid hormoneHuman keratinocytesParathyroid hormone receptor agonistsParathyroid hormone-like proteinSquamous epithelial originExtracts of tumorsHormone receptor agonistsHormone-like proteinHormone-like factorsAdenylate cyclase activityRat osteosarcoma cellsAdenylate cyclase productionNative parathyroid hormoneCultured human keratinocytesNormal human keratinocytesReceptor agonistMalignant tumorsCyclic adenosine monophosphateHypercalcemiaEpithelial originKeratinocyte-conditioned mediumMalignancyCyclase activityCyclase production