2022
Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy
Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectrocorticographyElectroencephalographyHumansMagnetic Resonance ImagingRetrospective StudiesTreatment OutcomeConceptsTemporal lobe onsetSeizure freedomResective surgeryIndependent predictorsLesional MRIUnfavorable predictorRefractory epilepsyContinued medical treatmentEpilepsy surgical evaluationFactors Predicting OutcomeIntracranial EEG evaluationNonlesional extratemporal epilepsySubsequent seizure freedomSustained seizure freedomThorough presurgical evaluationSeizure-free outcomeClass II evidenceMedically Refractory EpilepsyRetrospective chart reviewKaplan-Meier curvesSelect clinical scenariosMultivariable regression analysisBest multivariable modelIntracranial EEGSeizure onset localization
2020
Neuroimaging Correlates of Lateralized Rhythmic Delta Activity, Lateralized Periodic Discharges, and Generalized Rhythmic Delta Activity on EEG in Critically Ill Patients
Alzawahmah M, Fong MWK, Gilmore EJ, Hirsch LJ. Neuroimaging Correlates of Lateralized Rhythmic Delta Activity, Lateralized Periodic Discharges, and Generalized Rhythmic Delta Activity on EEG in Critically Ill Patients. Journal Of Clinical Neurophysiology 2020, 39: 228-234. PMID: 33235178, DOI: 10.1097/wnp.0000000000000763.Peer-Reviewed Original ResearchMeSH KeywordsCritical IllnessElectroencephalographyHumansMagnetic Resonance ImagingNeuroimagingRetrospective StudiesConceptsRhythmic delta activityDelta activityMRI abnormalitiesNormal MRIGeneralized rhythmic delta activityLateralized rhythmic delta activityLateralized periodic dischargesCritically Ill PatientsMajority of patientsMultifocal abnormalitiesIll patientsFocal findingsMRI characteristicsFocal abnormalitiesLRDAPatientsDiscordant findingsEpileptiform patternsMost abnormalitiesContinuous EEGPeriodic dischargesAbnormalitiesEEG patternsStatistical significanceMRI
2018
Presurgical language fMRI: Technical practices in epilepsy surgical planning
Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingChildClinical ProtocolsEpilepsyHumansLanguageLanguage TestsMagnetic Resonance ImagingNeurosurgical ProceduresPreoperative CareResearch DesignConceptsLanguage functional MRIFunctional MRISurgical planningEpilepsy surgical planningEpilepsy surgical programsGeneral linear modelingBlood flowClinical practicePatient careSurgical programsRoutine useMarked heterogeneityClinical applicationVerbal fluencyData highlightFMRI dataMost programsPatientsWidespread useEpilepsyIndividualsMRICareClinical Correlates of Periodic Discharges and Nonconvulsive Seizures in Posterior Reversible Encephalopathy Syndrome (PRES)
Bastide L, Legros B, Rampal N, Gilmore EJ, Hirsch LJ, Gaspard N. Clinical Correlates of Periodic Discharges and Nonconvulsive Seizures in Posterior Reversible Encephalopathy Syndrome (PRES). Neurocritical Care 2018, 29: 481-490. PMID: 29949000, DOI: 10.1007/s12028-018-0548-2.Peer-Reviewed Original ResearchConceptsPosterior reversible encephalopathy syndromeReversible encephalopathy syndromeContinuous electroencephalography monitoringGlasgow Outcome ScaleNonconvulsive seizuresPeriodic dischargesEncephalopathy syndromeRisk factorsWorse outcomesEpileptiform patternsMagnetic resonance imaging (MRI) abnormalitiesRetrospective cohort studyCEEG findingsEligible patientsRelated seizuresCohort studyHospital dischargeLow disabilityIll patientsImaging abnormalitiesMedical chartsClinical featuresPathophysiological mechanismsEEG findingsFunctional outcomePresurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning
Benjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Połczyńska M, Spencer DD, Hirsch LJ. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Human Brain Mapping 2018, 39: 2777-2785. PMID: 29528160, PMCID: PMC6033659, DOI: 10.1002/hbm.24039.Peer-Reviewed Original ResearchMeSH KeywordsBrain MappingEpilepsyHumansLanguageMagnetic Resonance ImagingNeurosurgical ProceduresOutcome Assessment, Health CarePreoperative CareConceptsLanguage functional MRISurgical marginsFunctional MRIPatient outcomesClinical practiceEpilepsy surgical planningEpilepsy surgical programsCurrent clinical practiceDirect brain stimulationEpilepsy surgeryStimulation mappingBrain stimulationClinical teamLanguage lateralizationSurgical programsSurgical planningLanguage-critical areasFMRI findingsFMRI paradigmUnexpected preservationFurther validationLanguage declineAdultsOutcomesChildren
2017
Presurgical language fMRI: Mapping of six critical regions
Benjamin CF, Walshaw PD, Hale K, Gaillard WD, Baxter LC, Berl MM, Polczynska M, Noble S, Alkawadri R, Hirsch LJ, Constable RT, Bookheimer SY. Presurgical language fMRI: Mapping of six critical regions. Human Brain Mapping 2017, 38: 4239-4255. PMID: 28544168, PMCID: PMC5518223, DOI: 10.1002/hbm.23661.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingBrain NeoplasmsEpilepsyFemaleHumansIntraoperative CareLanguageMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsYoung AdultConceptsLanguage lateralityWernicke's areaLanguage regionsBasal temporal language areaHum Brain MappTemporal language areaTumor patientsLanguage cortexIndependent cliniciansClinical fMRIExperienced cliniciansCliniciansLanguage mappingLanguage-critical areasSpeech areasAngular gyrusExner's areaLateralityFMRI taskBroca's areaBlind reviewNeurosurgical planningLanguage areasClinical neuropsychologistsFMRI dataSurgical outcome in adolescents with mesial temporal sclerosis: Is it different?
Farooque P, Hirsch L, Levy S, Testa F, Mattson R, Spencer D. Surgical outcome in adolescents with mesial temporal sclerosis: Is it different? Epilepsy & Behavior 2017, 69: 24-27. PMID: 28235653, DOI: 10.1016/j.yebeh.2016.10.028.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisTemporal sclerosisStatus epilepticusTemporal lobectomySurgical outcomesAdolescent patientsIctal onsetMore lobesEpilepsy surgery databaseScalp EEGSeizure freedomPatient populationSurgery DatabaseRisk factorsPatientsElectrographic dataLobectomyEpilepticusTwo yearsSclerosisHypometabolismNovel findingsAdolescentsMRIOutcomes
2015
Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography
King-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck CN, Goldman A, Jobst B, Shields DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, Gross RE, Cole AJ, Sperling MR, Nair DR, Gwinn RP, Park YD, Rutecki PA, Fountain NB, Wharen RE, Hirsch LJ, Miller IO, Barkley GL, Edwards JC, Geller EB, Berg MJ, Sadler TL, Sun FT, Morrell MJ. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia 2015, 56: 959-967. PMID: 25988840, PMCID: PMC4676303, DOI: 10.1111/epi.13010.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyChronic ambulatory electrocorticographyElectrographic seizuresTemporal lobe epilepsyMTL epilepsySeizure lateralizationLobe epilepsyTreatment decisionsMTL seizuresInpatient video-electroencephalography (EEG) monitoringIctal ECoG activityInpatient video-EEG monitoringVideo-electroencephalography monitoringVideo-EEG monitoringIntractable epilepsySeizure focusECoG activityLarge cohortAmbulatory settingResponsive neurostimulationPatientsSeizuresEpilepsyIntracranial electrodesECoG
2014
Limbic Encephalitis Associated With Anti–Voltage-Gated Potassium Channel Complex Antibodies Mimicking Creutzfeldt-Jakob Disease
Yoo JY, Hirsch LJ. Limbic Encephalitis Associated With Anti–Voltage-Gated Potassium Channel Complex Antibodies Mimicking Creutzfeldt-Jakob Disease. JAMA Neurology 2014, 71: 79-82. PMID: 24247910, DOI: 10.1001/jamaneurol.2013.5179.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseFaciobrachial dystonic seizuresDystonic seizuresLimbic encephalitisPotassium channel complex antibodiesAbnormal basal gangliaCommon treatable conditionsMagnetic resonance imagingNonparaneoplastic formsProgressive confusionClinical featuresBasal gangliaTreatable conditionTreatable diseaseComplete resolutionSimilar presentationComplex antibodiesRapid onsetResonance imagingSyndromeEncephalitisReversible conditionDiseaseSeizuresImmunotherapy
2013
Similarity of Lateralized Rhythmic Delta Activity to Periodic Lateralized Epileptiform Discharges in Critically Ill Patients
Gaspard N, Manganas L, Rampal N, Petroff OA, Hirsch LJ. Similarity of Lateralized Rhythmic Delta Activity to Periodic Lateralized Epileptiform Discharges in Critically Ill Patients. JAMA Neurology 2013, 70: 1288-1295. PMID: 23921464, DOI: 10.1001/jamaneurol.2013.3475.Peer-Reviewed Original ResearchConceptsLateralized rhythmic delta activityRhythmic delta activityContinuous EEG monitoringIll patientsDelta activityPeriodic dischargesAcute seizuresClinical significanceIll subjectsEEG monitoringEEG patternsPeriodic lateralized epileptiform dischargesJuxtacortical white matterContinuous electroencephalography monitoringIntensive care unitCross-sectional prevalenceFocal EEG abnormalitiesAcademic medical centerSimilar clinical significanceRadiological correlatesEarly seizuresMost patientsAcute illnessDischarge groupIndependent predictorsSeizure localization using three-dimensional surface projections of intracranial EEG power
Lee HW, Youngblood MW, Farooque P, Han X, Jhun S, Chen WC, Goncharova I, Vives K, Spencer DD, Zaveri H, Hirsch LJ, Blumenfeld H. Seizure localization using three-dimensional surface projections of intracranial EEG power. NeuroImage 2013, 83: 616-626. PMID: 23850575, PMCID: PMC3815983, DOI: 10.1016/j.neuroimage.2013.07.010.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingElectroencephalographyEpilepsyFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleSeizuresConceptsEpilepsy surgerySeizure localizationGood surgical outcomeEEG powerIntractable epilepsy patientsAgreement rateNormal brain functionOverall agreement ratePoor outcomeSurgical outcomesIntractable epilepsyIcEEG recordingsSeizure onsetSublobar localizationEpilepsy patientsIndependent reviewersClinical informationIcEEG dataPatientsBrain functionSurgeryImproved diagnostic methodIntracranial EEGDiagnostic methodsOutcomesIntracranial EEG evaluation of relationship within a resting state network
Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingChildElectroencephalographyEpilepsy, Frontal LobeFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleNerve NetParietal LobeYoung AdultConceptsDefault mode networkIntracranial EEG evaluationMode networkLocalization-related epilepsyCross-approximate entropyNeuronal involvementHemodynamic measurementsIntracranial EEG recordingsEEG evaluationBackground activityGamma powerFMRI studyIntracranial EEGBrain activityPatientsEEG recordingsLow levelsT2EpilepsyMagnitude squared coherenceT1
2008
Continuous Electroencephalographic Monitoring in Critically Ill Patients With Central Nervous System Infections
Carrera E, Claassen J, Oddo M, Emerson RG, Mayer SA, Hirsch LJ. Continuous Electroencephalographic Monitoring in Critically Ill Patients With Central Nervous System Infections. JAMA Neurology 2008, 65: 1612-1618. PMID: 19064748, DOI: 10.1001/archneur.65.12.1612.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCentral Nervous System InfectionsChi-Square DistributionCohort StudiesCritical IllnessElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMonitoring, PhysiologicRetrospective StudiesSeizuresStatistics, NonparametricX-Ray MicrotomographyYoung AdultConceptsCentral nervous system infectionNervous system infectionPeriodic epileptiform dischargesContinuous electroencephalographic monitoringElectrographic seizuresSystem infectionElectroencephalographic monitoringIll patientsPoor outcomeClinical correlatesEpileptiform dischargesPrimary central nervous system infectionCritically Ill PatientsRetrospective cohort studyNeurocritical care unitElectrographic findingsCohort studyConsecutive patientsCare unitViral causeClinical significancePatientsMonitoring findingsInfectionAdditional studiesFocal motor seizures induced by alerting stimuli in critically ill patients
Hirsch LJ, Pang T, Claassen J, Chang C, Khaled KA, Wittman J, Emerson RG. Focal motor seizures induced by alerting stimuli in critically ill patients. Epilepsia 2008, 49: 968-973. PMID: 18177364, DOI: 10.1111/j.1528-1167.2007.01481.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnticonvulsantsArousalBrain Damage, ChronicBrain StemChildCritical CareDominance, CerebralElectroencephalographyEpilepsy, Partial, MotorEpilepsy, ReflexFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsSubstance Withdrawal SyndromeTemporal LobeThalamusVideo RecordingConceptsFocal motor seizuresMotor seizuresIll patientsEEG findingsTertiary care medical centerVideo-EEG findingsNonconvulsive status epilepticusReview of chartsElectrographic seizure activityFocal EEG findingsArousal circuitryHyperexcitable cortexEncephalopathic patientsAcute illnessClinical seizuresStatus epilepticusBilateral thalamusComatose patientsElectrographic seizuresUpper brainstemSeizure activityClinical correlatesEpileptiform activityMotor pathwaysNeurological ICU