2020
Author response: New onset refractory status epilepticus research: What is on the horizon?
Gofton TE, Hirsch LJ. Author response: New onset refractory status epilepticus research: What is on the horizon? Neurology 2020, 94: 596. PMID: 32229639, DOI: 10.1212/wnl.0000000000009187.Peer-Reviewed Original Research
2019
Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy.
Ghassemi MM, Amorim E, Alhanai T, Lee JW, Herman ST, Sivaraju A, Gaspard N, Hirsch LJ, Scirica BM, Biswal S, Moura Junior V, Cash SS, Brown EN, Mark RG, Westover MB. Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy. Critical Care Medicine 2019, 47: 1416-1423. PMID: 31241498, PMCID: PMC6746597, DOI: 10.1097/ccm.0000000000003840.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyNeurologic outcomeElectroencephalogram featuresAcute hypoxic-ischemic encephalopathyAcademic medical centerBetter prognostic predictionReceiver operator curveNeurologic recoveryComatose patientsPrognostic implicationsCardiac arrestMedical CenterPrognostication performancePrognostic predictionOperator curveLogistic regressionSequential logistic regressionSpecificity thresholdEncephalopathyStatistical associationOutcomes
2018
Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsy
Detyniecki K, O'Bryan J, Choezom T, Rak G, Ma C, Zhang S, Bonito J, Hirsch LJ. Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsy. Epilepsy & Behavior 2018, 88: 349-356. PMID: 30344026, DOI: 10.1016/j.yebeh.2018.09.035.Peer-Reviewed Original ResearchConceptsRescue medication useProspective observational studyEmergency department visitsHigh seizure frequencySeizure clustersAdult patientsRescue medicationClinical characteristicsSeizure frequencyActive epilepsyDepartment visitsMedication useObservational studyExact testSeizure-related outcomesFisher's exact testLogistic regression modelsSeizure clusteringAdverse outcomesEpilepsy severitySeizure diariesIndividual patientsPatientsEpilepsyFinal analysis
2008
Updates in the Management of Seizures and Status Epilepticus in Critically Ill Patients
Khaled K, Hirsch LJ. Updates in the Management of Seizures and Status Epilepticus in Critically Ill Patients. Neurologic Clinics 2008, 26: 385-408. PMID: 18514819, DOI: 10.1016/j.ncl.2008.03.017.Peer-Reviewed Original ResearchConceptsStatus epilepticusIll patientsManagement of seizuresOrgan transplant patientsRenal failure patientsReversal of factorsFirstline treatmentSystemic sequelaeTransplant patientsAntiseizure medicationsFailure patientsSeizure thresholdEarly recognitionElectroencephalogram monitoringMaximal responseSpecific treatmentPatientsMetabolic imbalanceEpilepticusMedicationsSeizuresTreatmentSequelaeFeverHypoxia
2006
Advances in the Management of Seizures and Status Epilepticus in Critically Ill Patients
Khaled K, Hirsch LJ. Advances in the Management of Seizures and Status Epilepticus in Critically Ill Patients. Critical Care Clinics 2006, 22: 637-659. PMID: 17239748, DOI: 10.1016/j.ccc.2006.06.004.Peer-Reviewed Original ResearchConceptsStatus epilepticusIll patientsAnti-seizure medicationsFirst-line treatmentManagement of seizuresOrgan transplant patientsRenal failure patientsReversal of factorsSystemic sequelaeTransplant patientsFailure patientsSeizure thresholdEarly recognitionElectroencephalogram monitoringMaximal responseSpecific treatmentPatientsMetabolic imbalanceEpilepticusMedicationsSeizuresTreatmentSequelaeFeverHypoxia
2004
Stimulus‐induced Rhythmic, Periodic, or Ictal Discharges (SIRPIDs): A Common EEG Phenomenon in the Critically Ill
Hirsch LJ, Claassen J, Mayer SA, Emerson RG. Stimulus‐induced Rhythmic, Periodic, or Ictal Discharges (SIRPIDs): A Common EEG Phenomenon in the Critically Ill. Epilepsia 2004, 45: 109-123. PMID: 14738418, DOI: 10.1111/j.0013-9580.2004.38103.x.Peer-Reviewed Original ResearchConceptsContinuous EEG monitoringIctal dischargesEEG patternsClinical status epilepticusAcute brain injuryPeriodic epileptiform dischargesEEG phenomenaPrior epilepsyEncephalopathic patientsAcute illnessClinical seizuresConsecutive patientsIll patientsSpontaneous seizuresStatus epilepticusPatients stimulationBrain injuryEpileptiform dischargesSIRPIDsPatientsEEG monitoringTherapeutic significanceSeizuresSignificant differencesStimulation