2018
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol
Vespa PM, Shrestha V, Abend N, Agoston D, Au A, Bell MJ, Bleck TP, Blanco MB, Claassen J, Diaz-Arrastia R, Duncan D, Ellingson B, Foreman B, Gilmore EJ, Hirsch L, Hunn M, Kamnaksh A, McArthur D, Morokoff A, O'Brien T, O'Phelan K, Robertson CL, Rosenthal E, Staba R, Toga A, Willyerd FA, Zimmermann L, Yam E, Martinez S, Real C, Engel J. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol. Neurobiology Of Disease 2018, 123: 110-114. PMID: 30048805, PMCID: PMC6344322, DOI: 10.1016/j.nbd.2018.07.025.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyTraumatic brain injuryIncidence of PTELongitudinal prospective observational studyAnti-epileptogenic therapiesEpilepsy Bioinformatics StudyProspective observational studyFuture interventional studiesModerate-severe TBI patientsHemorrhagic contusionAcute evaluationTBI patientsBlood biomarkersDiscovery of biomarkersInterventional studyBrain injuryElectroencephalographic monitoringObservational studyInternational cohortAnimal modelsClinical biomarkersStudy designBiomarkersMultidisciplinary approachNational Institute
2010
Urgent Continuous EEG (cEEG) Monitoring Leads to Changes in Treatment in Half of Cases
Hirsch LJ. Urgent Continuous EEG (cEEG) Monitoring Leads to Changes in Treatment in Half of Cases. Epilepsy Currents 2010, 10: 82-85. PMID: 20697500, PMCID: PMC2912537, DOI: 10.1111/j.1535-7511.2010.01364.x.Peer-Reviewed Original ResearchContinuous electroencephalographic monitoringIntensive care unitAED therapyElectroencephalographic monitoringCare unitElectrographic seizuresNeuroscience intensive care unitAntiepileptic drug therapyRetrospective cohort studyContinuous EEG monitoringAED prescribingAntiepileptic medicationsCohort studyElectroencephalographic findingsNeurological wardDrug therapyElectroencephalographic abnormalitiesInpatient settingAED changesEEG monitoringTherapySeizuresIndividual inpatientsPrescribingFindings
2008
Continuous Electroencephalographic Monitoring in Critically Ill Patients With Central Nervous System Infections
Carrera E, Claassen J, Oddo M, Emerson RG, Mayer SA, Hirsch LJ. Continuous Electroencephalographic Monitoring in Critically Ill Patients With Central Nervous System Infections. JAMA Neurology 2008, 65: 1612-1618. PMID: 19064748, DOI: 10.1001/archneur.65.12.1612.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCentral Nervous System InfectionsChi-Square DistributionCohort StudiesCritical IllnessElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMonitoring, PhysiologicRetrospective StudiesSeizuresStatistics, NonparametricX-Ray MicrotomographyYoung AdultConceptsCentral nervous system infectionNervous system infectionPeriodic epileptiform dischargesContinuous electroencephalographic monitoringElectrographic seizuresSystem infectionElectroencephalographic monitoringIll patientsPoor outcomeClinical correlatesEpileptiform dischargesPrimary central nervous system infectionCritically Ill PatientsRetrospective cohort studyNeurocritical care unitElectrographic findingsCohort studyConsecutive patientsCare unitViral causeClinical significancePatientsMonitoring findingsInfectionAdditional studies
2007
Cyclic electrographic seizures in critically ill patients
Friedman DE, Schevon C, Emerson RG, Hirsch LJ. Cyclic electrographic seizures in critically ill patients. Epilepsia 2007, 49: 281-287. PMID: 17900293, DOI: 10.1111/j.1528-1167.2007.01327.x.Peer-Reviewed Original ResearchConceptsCyclic seizuresIll patientsPattern of seizuresStandard EEG recordingsNonconvulsive seizuresStatus epilepticusElectrographic seizuresSeizure activityUnderlying pathophysiologyElectroencephalographic monitoringSeizure initiationEEG frequency spectrumPatientsSeizuresContinuous EEGEEG powerPathophysiologyEEG recordingsCsAEpilepticusCessation
2006
Frequency and Predictors of Nonconvulsive Seizures During Continuous Electroencephalographic Monitoring in Critically Ill Children
Jette N, Claassen J, Emerson RG, Hirsch LJ. Frequency and Predictors of Nonconvulsive Seizures During Continuous Electroencephalographic Monitoring in Critically Ill Children. JAMA Neurology 2006, 63: 1750-1755. PMID: 17172615, DOI: 10.1001/archneur.63.12.1750.Peer-Reviewed Original ResearchConceptsContinuous electroencephalographic monitoringPeriodic lateralized epileptiform dischargesNonconvulsive seizuresIll childrenElectroencephalographic monitoringEpileptiform dischargesMultivariate logistic regression analysisMajority of patientsLogistic regression analysisAbsence of reactivityCEEG initiationClinical seizuresStatus epilepticusPrior seizuresSeizuresMultivariate analysisFirst hourChildrenPatientsRegression analysisBackground reactivityHoursPredictorsHours of recordingsEpilepticus
2005
Which EEG Patterns Warrant Treatment in the Critically Ill? Reviewing the Evidence for Treatment of Periodic Epileptiform Discharges and Related Patterns
Chong DJ, Hirsch LJ. Which EEG Patterns Warrant Treatment in the Critically Ill? Reviewing the Evidence for Treatment of Periodic Epileptiform Discharges and Related Patterns. Journal Of Clinical Neurophysiology 2005, 22: 79-91. PMID: 15805807, DOI: 10.1097/01.wnp.0000158699.78529.af.Peer-Reviewed Original ResearchConceptsNonconvulsive seizuresPeriodic dischargesContinuous electroencephalographic monitoringPeriodic epileptiform dischargesCritically IllNeuronal injuryIll patientsElectrographic patternsElectroencephalographic monitoringEpileptiform dischargesClinical settingEEG patternsCurrent criteriaSeizuresTreatmentManagement recommendationsDischargePatientsEtiologyInjuryDiagnosis