Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits
Martin J, Khramtsova E, Goleva S, Blokland G, Traglia M, Walters R, Hübel C, Coleman J, Breen G, Børglum A, Demontis D, Grove J, Werge T, Bralten J, Bulik C, Lee P, Mathews C, Peterson R, Winham S, Wray N, Edenberg H, Guo W, Yao Y, Neale B, Faraone S, Petryshen T, Weiss L, Duncan L, Goldstein J, Smoller J, Stranger B, Davis L, Consortium S, Alda M, Bortolato M, Burton C, Byrne E, Carey C, Erdman L, Huckins L, Mattheisen M, Robinson E, Stahl E. Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. Biological Psychiatry 2021, 89: 1127-1137. PMID: 33648717, PMCID: PMC8163257, DOI: 10.1016/j.biopsych.2020.12.024.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGenome-Wide Association StudyHumansMaleMultifactorial InheritancePhenotypePolymorphism, Single NucleotideSex CharacteristicsConceptsSex-differential effectsSex differencesGenetic architectureBehavioral traitsSingle nucleotide polymorphism (SNP)-based heritabilityGenetic correlationsGenome-wide association summary statisticsSNP-based heritabilityMultiple gene setsOrigins of sex differencesAssociation summary statisticsIdentified 4 genesGene-based approachRisk-taking behaviorIdentified genesGene setsWell-powered studiesBehavioral phenotypesBiological functionsGenetic contributionBetween-sexGenetic effectsTrait pairsGenetic correlation estimatesNeuron-related