2021
Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Iron Deficiency Anemia
Li X, Lozovatsky L, Fretz J, Finberg K. Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Iron Deficiency Anemia. Blood 2021, 138: 759. DOI: 10.1182/blood-2021-153329.Peer-Reviewed Original ResearchIron deficiency anemiaSinusoidal endothelial cellsBone marrow sinusoidal endothelial cellsNon-anemic controlsBone marrowFGF23 upregulationEndothelial cellsHepcidin elevationDeficiency anemiaFGF23 productionSerum erythropoietinChronic iron deficiency anemiaIron deficiencyFGF23 promoter activityTissue iron deficiencyIron-restricted anemiaFemurs of miceSystemic iron deficiencyBone marrow sectionsReporter alleleNormal iron balanceEndothelial cell subtypesTotal FGF23Phosphaturic hormoneBlood loss
2020
NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss
Li X, Lozovatsky L, Sukumaran A, Gonzalez L, Jain A, Liu D, Ayala-Lopez N, Finberg KE. NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss. Blood 2020, 136: 2691-2702. PMID: 32659785, PMCID: PMC7735158, DOI: 10.1182/blood.2020006321.Peer-Reviewed Original ResearchConceptsHepatic iron storesHypoxia-inducible factorNonheme iron concentrationsIron storesBlood lossNCOA4 expressionSubunit levelsHIF-2α knockdownMurine hepatoma cell lineMessenger RNA inductionDietary ironHepatic responseHepatoma cell lineHIF-1αHepatic originIron deficiencyInducible factorMiceCell linesNCOA4PhlebotomyModest effectRNA inductionIron concentrationProlyl hydroxylases