2024
Research utilization competency development in the health workforce pipeline: Design and formative evaluation of learning objectives for health professions students
Yini Karway O, Wleh J, Kpatakolee Y, Sieka J, Candy N, Talbert-Slagle K, Dahn B, Harmon-Gray W, Skrip L. Research utilization competency development in the health workforce pipeline: Design and formative evaluation of learning objectives for health professions students. Health Research Policy And Systems 2024, 22: 158. PMID: 39623382, PMCID: PMC11610060, DOI: 10.1186/s12961-024-01238-z.Peer-Reviewed Original ResearchConceptsHealth professions schoolsResearch utilizationWorkforce pipelineApplication of research evidenceHealth sectorResearch evidenceSchool of Public HealthMiddle-income country contextsGroup discussionsMethodsFocus group discussionsHealth professions studentsCollege of Health SciencesFocus group participantsFormative evaluationFocus group discussionsLife-saving interventionsProfessions studentsHealth policyGroup participantsTime commitmentHealthHealth SciencesPublic healthPharmacy schoolsCompetency areasExploring equity in global health collaborations: a qualitative study of donor and recipient power dynamics in Liberia
Cakouros B, Gum J, Levine D, Lewis J, Wright A, Dahn B, Talbert-Slagle K. Exploring equity in global health collaborations: a qualitative study of donor and recipient power dynamics in Liberia. BMJ Global Health 2024, 9: e014399. PMID: 38485141, PMCID: PMC10946382, DOI: 10.1136/bmjgh-2023-014399.Peer-Reviewed Original ResearchConceptsGlobal health collaborationsHealth collaborationLow-resource settingsThematic analysisPriority settingQualitative studyImplementing partnersEquitable partnershipsInformant interviewsDecision makingGlobal health donorsPower structuresLived experiencePatterns of accountabilityImplementation planNon-governmental organisationsHigh resourcesFinancial controlPower differentialsQualitative analysisForeign donorsEquitable decision makingEquitable collaborationExternal aidsIntentional efforts
2023
Transforming medical education in Liberia through an international community of inquiry
Talbert-Slagle K, Ajami I, Currey B, Galvao R, Hadush J, Li S, Flowers J, Ziah M, Amuh D, Rabb M, Ilesanmi O, Allen N, Martin M, Miller M, Yaman A, Nuthulaganti T, Plyler C, Kumeh O, Sieka J, Ogbuagu O, Marsh R, Rastegar A, Sherman L, Adams Z, Benson A, Dahn B. Transforming medical education in Liberia through an international community of inquiry. PLOS Global Public Health 2023, 3: e0001610. PMID: 36963025, PMCID: PMC10021565, DOI: 10.1371/journal.pgph.0001610.Peer-Reviewed Original ResearchCommunity of inquiryOnly medical schoolMedical educationPhysician workforceUndergraduate medical educationEvidence-informed practiceU.S. academic institutionsInquiry approachMedical schoolsMutual learning processGlobal health partnershipsEducationAcademic institutionsBuilding capacityInquirySchoolsOrganizational transformationFacultyInstitutional affiliationHealth partnershipsPartnershipMethod assessmentSector stakeholdersNon-governmental organizationsStrategic planning
2022
Using an Evidence-based Framework to Guide the Implementation of Syringe Services Programs in Jackson, Mississippi
Eger W, Talbert-Slagle K, Allen H. Using an Evidence-based Framework to Guide the Implementation of Syringe Services Programs in Jackson, Mississippi. HPHR Journal 2022 DOI: 10.54111/0001/ww3.Peer-Reviewed Original ResearchSyringe services programBlood-borne infectionsInjection drug useHuman immunodeficiency virusDrug useHigh HIV infection ratesHIV infection ratesEvidence-based interventionsPublic health expertsPopulation of peopleDepartment of HealthViral hepatitisHIV infectionImmunodeficiency virusOpioid epidemicEvidence-based commentaryInfection rateDrug paraphernaliaConsolidated FrameworkInfectious diseasesDisease controlEvidence-based frameworkInfectionHealth expertsImplementation research
2014
Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body
Talbert-Slagle K, Atkins KE, Yan KK, Khurana E, Gerstein M, Bradley EH, Berg D, Galvani AP, Townsend JP. Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body. PLOS Pathogens 2014, 10: e1004092. PMID: 24811311, PMCID: PMC4014458, DOI: 10.1371/journal.ppat.1004092.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSmall transmembrane protein inhibitors of the platelet‐derived growth factor β receptor (LB215)
Petti L, Talbert‐Slagle K, Chacon K, Hochstrasser M, DiMaio D. Small transmembrane protein inhibitors of the platelet‐derived growth factor β receptor (LB215). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.lb215.Peer-Reviewed Original ResearchTransmembrane domainTransmembrane proteinPlatelet-derived growth factor β receptorProtein inhibitorGrowth factor receptor signalingSingle conservative amino acid substitutionSmall transmembrane proteinConservative amino acid substitutionsGrowth factor β receptorParticular tyrosine residueReceptor tyrosine kinasesAmino acid substitutionsSequence similarityGrowth factor receptorTraptamersReceptor dimerizationEffects of PDGFSmall proteinsTyrosine residuesExtracellular domainTyrosine kinaseAcid substitutionsReceptor signalingRetroviral libraryPDGFβR
2013
A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor*
Petti LM, Talbert-Slagle K, Hochstrasser ML, DiMaio D. A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor*. Journal Of Biological Chemistry 2013, 288: 27273-27286. PMID: 23908351, PMCID: PMC3779723, DOI: 10.1074/jbc.m113.470054.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBovine papillomavirus 1CattleCell LineCell Transformation, ViralEnzyme ActivatorsFibroblastsHumansMaleMiceMutation, MissenseOncogene Proteins v-sisOncogene Proteins, ViralPhosphorylationProtein Kinase InhibitorsReceptor, Platelet-Derived Growth Factor betaSignal TransductionConceptsTransmembrane domainTransmembrane proteinPlatelet-derived growth factor β receptorLimited sequence similarityGrowth factor β receptorParticular tyrosine residueLigand-independent mannerSequence similarityGenetic evidenceGrowth factor receptorE5 proteinOncogenic transformationWild typeProtein activatorViral homologueTyrosine residuesE5 bindsProtein inhibitorPDGFβRV-sisPDGFβ receptorBovine papillomavirusFactor receptorNonidentical sitesCell proliferationInnovation spread: lessons from HIV
Talbert-Slagle K, Berg D, Bradley EH. Innovation spread: lessons from HIV. International Journal For Quality In Health Care 2013, 25: 352-356. PMID: 23696582, PMCID: PMC3723303, DOI: 10.1093/intqhc/mzt038.Peer-Reviewed Original Research
2012
A model for scale up of family health innovations in low-income and middle-income settings: a mixed methods study
Bradley EH, Curry LA, Taylor LA, Pallas SW, Talbert-Slagle K, Yuan C, Fox A, Minhas D, Ciccone DK, Berg D, Pérez-Escamilla R. A model for scale up of family health innovations in low-income and middle-income settings: a mixed methods study. BMJ Open 2012, 2: e000987. PMID: 22923624, PMCID: PMC3432850, DOI: 10.1136/bmjopen-2012-000987.Peer-Reviewed Original Research
2009
Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor β Receptor
Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM, DiMaio D. Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor β Receptor. Journal Of Virology 2009, 83: 9773-9785. PMID: 19605488, PMCID: PMC2748040, DOI: 10.1128/jvi.00946-09.Peer-Reviewed Original ResearchConceptsPDGF beta receptorTransmembrane domainBPV E5Transmembrane proteinBovine papillomavirus E5 proteinPlatelet-derived growth factor beta receptorArtificial transmembrane proteinsLigand-independent receptor activationPrimary amino acid sequenceSimilar cellular proteinsSmall artificial proteinsGrowth factor β receptorHomodimeric transmembrane proteinAmino acid sequenceGrowth factor beta receptorConsecutive amino acidsC-terminal cysteineSame cellular targetsNew genetic techniquesBeta receptorsCellular proteinsAcid sequenceE5 proteinGenetic techniquesSequence requirements
2008
The bovine papillomavirus E5 protein and the PDGF β receptor: It takes two to tango
Talbert-Slagle K, DiMaio D. The bovine papillomavirus E5 protein and the PDGF β receptor: It takes two to tango. Virology 2008, 384: 345-351. PMID: 18990418, PMCID: PMC2661243, DOI: 10.1016/j.virol.2008.09.033.Peer-Reviewed Original ResearchConceptsBovine papillomavirus E5 proteinE5 proteinTransmembrane domainTransmembrane proteinTarget proteinsPlatelet-derived growth factor beta receptorArtificial transmembrane proteinsMembrane-spanning segmentsHuman erythropoietin receptorBPV E5 proteinGrowth factor beta receptorCellular receptor tyrosine kinasesLigand-independent activationReceptor tyrosine kinasesGenetic screenPDGF β-receptorNovel proteinTransmembrane sequenceCellular proteinsMitogenic signalingHydrophobic proteinsReceptor dimerizationLarger target proteinsErythropoietin receptorSmall proteins
2005
Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT
Choi J, Walker J, Talbert-Slagle K, Wright P, Pober JS, Alexander L. Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT. Journal Of Virology 2005, 79: 11194-11204. PMID: 16103171, PMCID: PMC1193601, DOI: 10.1128/jvi.79.17.11194-11204.2005.Peer-Reviewed Original ResearchConceptsMemory T cellsHuman immunodeficiency virus (HIV) replicationImmunodeficiency virus replicationT cellsViral replicationEndothelial cellsAntiretroviral therapyHIV replicationSuboptimal T cell receptor (TCR) stimulationHIV Type 1 ReplicationVirus replicationMajor histocompatibility complex (MHC) class II moleculesType 1 replicationTumor necrosis factorMHC class IIClass II moleculesT cell receptor stimulationVirus-producing cellsReceptor-dependent activationNef-dependent mannerEffector cytokinesHuman endothelial cellsHLA-DRIL-6Presence of EC