2023
Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study
Sumner K, Masalovich S, O’Halloran A, Holstein R, Reingold A, Kirley P, Alden N, Herlihy R, Meek J, Yousey-Hindes K, Anderson E, Openo K, Monroe M, Leegwater L, Henderson J, Lynfield R, McMahon M, McMullen C, Angeles K, Spina N, Engesser K, Bennett N, Felsen C, Lung K, Shiltz E, Thomas A, Talbot H, Schaffner W, Swain A, George A, Rolfes M, Reed C, Garg S. Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study. The Lancet Microbe 2023, 4: e903-e912. PMID: 37769676, PMCID: PMC10872935, DOI: 10.1016/s2666-5247(23)00187-8.Peer-Reviewed Original ResearchConceptsInfluenza virus typeInfluenza-associated hospitalisationsInfluenza seasonInfluenza B virusICU admissionMechanical ventilationSevere outcomesOdds ratioVirus typeFluSurv-NETECMO useInfluenza vaccineB virusVirus infectionLaboratory-confirmed influenza virus infectionInfluenza Hospitalization Surveillance NetworkInfluenza B virus infectionPopulation-based surveillance systemComplete chart reviewEarly antiviral treatmentHospital-onset casesInfluenza-associated outcomesRepeated cross-sectional studyInfluenza vaccination statusB virus infection
2022
COVID-19-Associated Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, January 2021 to April 2022
Havers F, Pham H, Taylor C, Whitaker M, Patel K, Anglin O, Kambhampati A, Milucky J, Zell E, Moline H, Chai S, Kirley P, Alden N, Armistead I, Yousey-Hindes K, Meek J, Openo K, Anderson E, Reeg L, Kohrman A, Lynfield R, Como-Sabetti K, Davis E, Cline C, Muse A, Barney G, Bushey S, Felsen C, Billing L, Shiltz E, Sutton M, Abdullah N, Talbot H, Schaffner W, Hill M, George A, Hall A, Bialek S, Murthy N, Murthy B, McMorrow M. COVID-19-Associated Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, January 2021 to April 2022. JAMA Internal Medicine 2022, 182: 1071-1081. PMID: 36074486, PMCID: PMC9459904, DOI: 10.1001/jamainternmed.2022.4299.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCOVID-19COVID-19 VaccinesCross-Sectional StudiesHospitalizationHumansInfluenza VaccinesSARS-CoV-2ConceptsCOVID-19-associated hospitalizationUnderlying medical conditionsHospitalization ratesUnvaccinated personsVaccinated personsBooster doseMedical conditionsLaboratory-confirmed COVID-19-associated hospitalizationsLaboratory-confirmed SARS-CoV-2 infectionLong-term care facility residentsPositive SARS-CoV-2 test resultCOVID-19 Associated HospitalizationsDetailed medical record reviewImmunization information system dataSARS-CoV-2 test resultsCOVID-19-Associated Hospitalization Surveillance NetworkSARS-CoV-2 infectionCOVID-19Patients 18 yearsMedical record reviewCare facility residentsVaccination coverage dataAdults 18 yearsCross-sectional studyPublic health efforts
2021
Characteristics and Outcomes of Hospitalized Pregnant Women With Influenza, 2010 to 2019 : A Repeated Cross-Sectional Study.
Holstein R, Dawood FS, O'Halloran A, Cummings C, Ujamaa D, Daily Kirley P, Yousey-Hindes K, Fawcett E, Monroe ML, Kim S, Lynfield R, McMullen C, Muse A, Bennett NM, Billing LM, Sutton M, Thomas A, Talbot HK, Schaffner W, Risk I, Reed C, Garg S. Characteristics and Outcomes of Hospitalized Pregnant Women With Influenza, 2010 to 2019 : A Repeated Cross-Sectional Study. Annals Of Internal Medicine 2021, 175: 149-158. PMID: 34958603, DOI: 10.7326/m21-3668.Peer-Reviewed Original ResearchConceptsInfluenza-associated outcomesPregnant womenCross-sectional studyFetal outcomesHospital dischargeInfluenza seasonMechanical ventilationInfluenza Hospitalization Surveillance NetworkIntensive care unit admissionMedical chart abstractionRepeated cross-sectional studySevere maternal outcomesCare unit admissionLaboratory-confirmed influenzaReproductive-aged womenHospitalized pregnant womenInfluenza A H1N1Multivariable logistic regressionHigh-priority target groupUnit admissionHospital deathICU admissionMaternal outcomesChart abstractionClinical characteristicsRacial and Ethnic Disparities in Rates of COVID-19–Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death in the United States From March 2020 to February 2021
Acosta AM, Garg S, Pham H, Whitaker M, Anglin O, O’Halloran A, Milucky J, Patel K, Taylor C, Wortham J, Chai SJ, Kirley PD, Alden NB, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Weigel A, Monroe ML, Ryan P, Reeg L, Kohrman A, Lynfield R, Bye E, Torres S, Salazar-Sanchez Y, Muse A, Barney G, Bennett NM, Bushey S, Billing L, Shiltz E, Sutton M, Abdullah N, Talbot HK, Schaffner W, Ortega J, Price A, Fry AM, Hall A, Kim L, Havers FP. Racial and Ethnic Disparities in Rates of COVID-19–Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death in the United States From March 2020 to February 2021. JAMA Network Open 2021, 4: e2130479. PMID: 34673962, PMCID: PMC8531997, DOI: 10.1001/jamanetworkopen.2021.30479.Peer-Reviewed Original ResearchConceptsCOVID-19-associated hospitalizationIntensive care unit admissionCare unit admissionSevere COVID-19Age-adjusted ratesICU admissionHospital deathUnit admissionWhite personsPacific Islander personsLaboratory-confirmed COVID-19-associated hospitalizationsAlaska NativesCOVID-19Positive SARS-CoV-2 testCOVID-19 Associated HospitalizationsEthnic disparitiesCOVID-19-Associated Hospitalization Surveillance NetworkSARS-CoV-2 testNon-Hispanic white personsIn-Hospital DeathRate ratioCross-sectional studyNon-Hispanic American IndianEthnic minority groupsNon-Hispanic blacksClinical Trends Among U.S. Adults Hospitalized With COVID-19, March to December 2020
Garg S, Patel K, Pham H, Whitaker M, O'Halloran A, Milucky J, Anglin O, Kirley PD, Reingold A, Kawasaki B, Herlihy R, Yousey-Hindes K, Maslar A, Anderson EJ, Openo KP, Weigel A, Teno K, Ryan PA, Monroe ML, Reeg L, Kim S, Como-Sabetti K, Bye E, Davis S, Eisenberg N, Muse A, Barney G, Bennett NM, Felsen CB, Billing L, Shiltz J, Sutton M, Abdullah N, Talbot HK, Schaffner W, Hill M, Chatelain R, Wortham J, Taylor C, Hall A, Fry AM, Kim L, Havers FP. Clinical Trends Among U.S. Adults Hospitalized With COVID-19, March to December 2020. Annals Of Internal Medicine 2021, 174: m21-1991. PMID: 34370517, PMCID: PMC8381761, DOI: 10.7326/m21-1991.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine MonophosphateAdolescentAdrenal Cortex HormonesAdultAge DistributionAgedAlanineAntiviral AgentsCOVID-19Critical CareCross-Sectional StudiesFemaleHospitalizationHumansIntensive Care UnitsLength of StayMaleMiddle AgedPandemicsRespiration, ArtificialSARS-CoV-2United StatesVasoconstrictor AgentsYoung AdultConceptsICU admissionClinical trendsMechanical ventilationCOVID-19COVID-19-associated hospitalizationIntensive care unit admissionLaboratory-confirmed COVID-19U.S. adultsNon-Hispanic black personsCare unit admissionHospital death rateNoninvasive respiratory supportUse of remdesivirPercentage of interventionsCross-sectional studyCOVID-19 vaccineNon-Hispanic whitesSystemic corticosteroidsUnit admissionVasopressor useHospitalized adultsRespiratory supportCase patientsMedian ageSubstantial morbidityRates of Influenza-Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death by Race and Ethnicity in the United States From 2009 to 2019
O’Halloran A, Holstein R, Cummings C, Kirley P, Alden NB, Yousey-Hindes K, Anderson EJ, Ryan P, Kim S, Lynfield R, McMullen C, Bennett NM, Spina N, Billing LM, Sutton M, Schaffner W, Talbot HK, Price A, Fry AM, Reed C, Garg S. Rates of Influenza-Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death by Race and Ethnicity in the United States From 2009 to 2019. JAMA Network Open 2021, 4: e2121880. PMID: 34427679, PMCID: PMC8385599, DOI: 10.1001/jamanetworkopen.2021.21880.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalizationsIntensive care unit admissionCare unit admissionCross-sectional studyHospitalization ratesPacific Islander childrenHospital deathICU admissionUnit admissionInfluenza seasonMAIN OUTCOMELaboratory-confirmed influenza-associated hospitalizationsAge groupsAge-adjusted hospitalization ratesHospital death rateICU admission rateInfluenza-associated diseaseInfluenza-associated outcomesIn-Hospital DeathSevere influenza diseaseHispanic childrenPopulation-based surveillanceWhite personsAlaska NativesAge-stratified rates
2020
Acute Cardiovascular Events Associated With Influenza in Hospitalized Adults : A Cross-sectional Study.
Chow EJ, Rolfes MA, O'Halloran A, Anderson EJ, Bennett NM, Billing L, Chai S, Dufort E, Herlihy R, Kim S, Lynfield R, McMullen C, Monroe ML, Schaffner W, Spencer M, Talbot HK, Thomas A, Yousey-Hindes K, Reed C, Garg S. Acute Cardiovascular Events Associated With Influenza in Hospitalized Adults : A Cross-sectional Study. Annals Of Internal Medicine 2020, 173: 605-613. PMID: 32833488, PMCID: PMC8097760, DOI: 10.7326/m20-1509.Peer-Reviewed Original ResearchConceptsAcute ischemic heart diseaseAcute heart failureAcute cardiovascular eventsLaboratory-confirmed influenzaCardiovascular eventsCross-sectional studyInfluenza vaccinationDischarge codesInfluenza testingChronic conditionsTobacco useInfluenza Hospitalization Surveillance NetworkInfluenza antiviral medicationsMedical record abstractionIschemic heart diseasePopulation-based studyAnnual influenza epidemicsLogistic regression modelsCommon such eventsRace/ethnicityPractitioner ordersHospitalized adultsAntiviral medicationsHeart failureInfluenza seasonRespiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults
Chow EJ, Rolfes MA, O’Halloran A, Alden NB, Anderson EJ, Bennett NM, Billing L, Dufort E, Kirley PD, George A, Irizarry L, Kim S, Lynfield R, Ryan P, Schaffner W, Talbot HK, Thomas A, Yousey-Hindes K, Reed C, Garg S. Respiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults. JAMA Network Open 2020, 3: e201323. PMID: 32196103, PMCID: PMC7084169, DOI: 10.1001/jamanetworkopen.2020.1323.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaRespiratory diagnosesInfluenza seasonAcute diagnosisInfluenza Hospitalization Surveillance NetworkPositive influenza test resultsRevision discharge diagnosis codesSeasonal influenza virus infectionCommon acute diagnosesEarly antiviral treatmentAcute kidney injuryMedical record abstractionPatient demographic characteristicsDischarge diagnosis codesBurden of infectionInfluenza virus infectionInfluenza test resultsCross-sectional studyTranscription-polymerase chain reactionIndirect fluorescent stainingInternational Statistical ClassificationSurveillance networkRelated Health ProblemsFluSurv-NETHospital outcomes
2018
Clinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015
Collins JP, Campbell AP, Openo K, Farley MM, Cummings CN, Kirley PD, Herlihy R, Yousey-Hindes K, Monroe ML, Ladisky M, Lynfield R, Baumbach J, Spina N, Bennett N, Billing L, Thomas A, Schaffner W, Price A, Garg S, Anderson EJ. Clinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015. Journal Of The Pediatric Infectious Diseases Society 2018, 8: 539-549. PMID: 30358877, DOI: 10.1093/jpids/piy101.Peer-Reviewed Original ResearchConceptsSolid organ transplantationImmunocompromised childrenClinical featuresImmunosuppressive therapyIntensive careOrgan transplantationInfluenza Hospitalization Surveillance NetworkHuman immunodeficiency virus/Community-acquired influenzaEarly antiviral treatmentLonger hospitalization durationDuration of hospitalizationIntensive care admissionAntiviral useCare admissionHospital deathHospitalization durationInfluenza vaccinationAntiviral treatmentInfluenza seasonInfluenza severityPrimary outcomeImmunodeficiency syndromeMultivariable analysisImmunoglobulin deficiency