Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation
Petrovska I, Nüske E, Munder M, Kulasegaran G, Malinovska L, Kroschwald S, Richter D, Fahmy K, Gibson K, Verbavatz J, Alberti S. Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation. ELife 2014, 3: e02409. PMID: 24771766, PMCID: PMC4011332, DOI: 10.7554/elife.02409.Peer-Reviewed Original ResearchMetabolic enzymesCellular starvationFilament formationKey metabolic enzymesEnzyme glutamine synthetaseNutritional stressHigher order fibrilsGlutamine synthetaseFunctional roleMacromolecular crowdingSpecific adaptationsPhysical organizationGeneral mechanismStarvationEnzymeBack stackingEnzymatic inactivationIntracellular pHFilamentsMetabolismGLN1Broad implicationsCellsYeastBiology