An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch
Jahn SC, Law ME, Corsino PE, Parker NN, Pham K, Davis BJ, Lu J, Law BK. An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch. Cancer Letters 2012, 326: 183-190. PMID: 22906417, PMCID: PMC3705571, DOI: 10.1016/j.canlet.2012.08.013.Peer-Reviewed Original ResearchConceptsCancer cellsPre-EMT cellsNumber of genesMesenchymal transitionDNA microarray analysisEpithelial cell transitionPost-EMT cellsMitogenic signalingMicroarray analysisCell transitionMesenchymal phenotypeBreast cancer cellsERK phosphorylationLPA receptorsVivo modelMEK inhibitorsTissue architectureGrowth inhibitory effectsEpithelial cellsC-MetInhibitors/antagonistsPDGFCellsPhenotypeEMT