2021
E-Cigarettes Promote Macrophage-Tumor Cells Crosstalk: Focus on Breast Carcinoma Progression and Lung Metastasis
Pham K, DeFina S, Wang H. E-Cigarettes Promote Macrophage-Tumor Cells Crosstalk: Focus on Breast Carcinoma Progression and Lung Metastasis. Exploratory Research And Hypothesis In Medicine 2021, 6: 60-66. PMID: 35419501, PMCID: PMC9005083, DOI: 10.14218/erhm.2021.00002.Peer-Reviewed Original ResearchTumor-associated macrophagesBreast cancerMetastasis of BCTumor microenvironmentC motif chemokine ligand 5Enhanced tumor malignancyRisk of metastasisConventional cigarette smokingAggressive breast cancerChemokine ligand 5Breast carcinoma progressionCig vapingDNA damaging effectsCigarette smokingLung metastasesImmune cellsAggressive phenotypeBC progressionMacrophage activationCig useMetastasisTumor malignancyCarcinoma progressionE-cigsE-cigarettes
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment
Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER, Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM, George TJ, Brusko TM, Mathews CE, Liu C, Trevino JG, Hughes SJ, Wallet SM. Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment. Cancer Research 2017, 77: 672-683. PMID: 27864347, PMCID: PMC5290036, DOI: 10.1158/0008-5472.can-16-1765.Peer-Reviewed Original ResearchConceptsTumor-associated stromaPancreatic cancerTumor microenvironmentT cell-mediated cytotoxicityCancer cell-conditioned mediumImmunosuppressive tumor microenvironmentT cell proliferationCell-conditioned mediumHuman cell culture modelsTh1 ratioProtective immunityCancer differsHealthy controlsMemory Th17Pancreatic lysatesCell culture modelPrimary human cell culture modelsRobust secretionCancer cellsCD8TA responsesPatientsImmunomodulatory characterCancerCulture model