2024
Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentation
2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionAssociation of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank.
Rivier C, Renedo D, de Havenon A, Sunmonu N, Gill T, Payabvash S, Sheth K, Falcone G. Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank. Neurology 2023, 102: e208010. PMID: 38165331, PMCID: PMC10870735, DOI: 10.1212/wnl.0000000000208010.Peer-Reviewed Original ResearchConceptsPoor oral healthOral healthBrain healthRisk factorsNeuroimaging markerWMH volumeHealth profileMD scoreSelf-reported poor oral healthCross-sectional neuroimaging studiesFractional anisotropyWhite matter hyperintensity volumeModifiable risk factorsWhite matter injuryPresence of denturesMendelian randomizationMiddle-aged personsFA scoreMiddle-aged participantsLoose teethCardiovascular diseaseHyperintensity volumeBrain MRIModifiable processEarly interventionImprovement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity
de Havenon A, Smith E, Sharma R, Falcone G, Bangad A, Prabhakaran S, Sheth K. Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity. Journal Of The American Heart Association 2023, 12: e029374. PMID: 37345754, PMCID: PMC10356061, DOI: 10.1161/jaha.123.029374.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesIncident strokePrimary outcomeHypertensive individualsMatter hyperintensitiesAtherosclerotic cardiovascular disease risk scoreCognitive impairmentCardiovascular disease risk scoreVascular risk factorsCurrent cigarette smokingDisease risk scoreMagnetic resonance imagingLogistic regression modelsRandomization armCerebrovascular eventsVascular riskCigarette smokingPrognostic informationRisk factorsPrognostic abilityRisk scoreCognitive declineResonance imagingDeLong testStrokeIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexBlood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults
Acosta J, Haider S, Rivier C, Leasure A, Sheth K, Falcone G, Payabvash S. Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults. Stroke And Vascular Neurology 2023, 8: 358-367. PMID: 36878613, PMCID: PMC10647862, DOI: 10.1136/svn-2022-001929.Peer-Reviewed Original Research
2015
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke
Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Barrick TR, Moynihan B, Lewis CM, Boncoraglio GB, Lemmens R, Thijs V, Sudlow C, Wardlaw J, Rothwell PM, Meschia JF, Worrall BB, Levi C, Bevan S, Furie KL, Dichgans M, Rosand J, Markus HS, Rost N, Smoller S, Sorkin J, Wang X, Selim M, Pikula A, Wolf P, Debette S, Seshadri S, de Bakker P, Chasman D, Rexrode K, Chen I, Rotter J, Luke M, Sale M, Lee T, Chang K, Elkind M, Goldstein L, James M, Breteler M, O'Donnell C, Leys D, Carty C, Kidwell C, Olesen J, Sharma P, Rich S, Tatlisumak T, Happola O, Bijlenga P, Soriano C, Giralt E, Roquer J, Jimenez-Conde J, Cotlarcius I, Hardy J, Korostynski M, Boncoraglio G, Ballabio E, Parati E, Mateusz A, Urbanik A, Dziedzic T, Jagiella J, Gasowski J, Wnuk M, Olszanecki R, Pera J, Slowik A, Juchniewicz K, Levi C, Nyquist P, Cendes I, Cabral N, Franca P, Goncalves A, Keller L, Crisby M, Kostulas K, Lemmens R, Ahmadi K, Opherk C, Duering M, Dichgans M, Malik R, Gonik M, Staals J, Melander O, Burri P, Sadr-Nabavi A, Romero J, Biffi A, Anderson C, Falcone G, Brouwers B, Rosand J, Rost N, Du R, Kourkoulis C, Battey T, Lubitz S, Mueller-Myhsok B, Meschia J, Brott T, Pare G, Pichler A, Enzinger C, Schmidt H, Schmidt R, Seiler S, Blanton S, Yamada Y, Bersano A, Rundek T, Sacco R, Yvonne Chan Y, Gschwendtner A, Deng Z, Barr T, Gwinn K, Corriveau R, Singleton A, Waddy S, Launer L, Chen C, Le K, Lee W, Tan E, Olugbodi A, Rothwell P, Schilling S, Mok V, Lebedeva E, Jern C, Jood K, Olsson S, Kim H, Lee C, Kilarski L, Markus H, Peycke J, Bevan S, Sheu W, Chiou H, Chern J, Giraldo E, Taqi M, Jain V, Lam O, Howard G, Woo D, Kittner S, Mitchell B, Cole J, O'Connell J, Milewicz D, Illoh K, Worrall B, Stine C, Karaszewski B, Werring D, Sofat R, Smalley J, Lindgren A, Hansen B, Norrving B, Smith G, Martín J, Thijs V, Klijn K, van't Hof F, Algra A, Macleod M, Perry R, Arnett D, Pezzini A, Padovani A, Cramer S, Fisher M, Saleheen D, Broderick J, Kissela B, Doney A, Sudlow C, Rannikmae K, Silliman S, McDonough C, Walters M, Pedersen A, Nakagawa K, Chang C, Dobbins M, McArdle P, Chang Y, Brown R, Brown D, Holliday E, Kalaria R, Maguire J, Attia J, Farrall M, Giese A, Fornage M, Majersik J, Cushman M, Keene K, Bennett S, Tirschwell D, Psaty B, Reiner A, Longstreth W, Spence D, Montaner J, Fernandez-Cadenas I, Langefeld C, Bushnell C, Heitsch L, Lee J, Sheth K. Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology 2015, 86: 146-153. PMID: 26674333, PMCID: PMC4731688, DOI: 10.1212/wnl.0000000000002263.Peer-Reviewed Original ResearchConceptsGenome-wide significant associationGenetic associationGenome-wide levelGenome-wide significanceMeta-analysis testingIndependent lociSuggestive lociGenetic lociLociDisease mechanismsNovel associationsGenetic susceptibilityPopulationCommon genetic susceptibilityDirection of effectReference dataset