2016
Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial
Sheth KN, Elm JJ, Molyneaux BJ, Hinson H, Beslow LA, Sze GK, Ostwaldt AC, del Zoppo GJ, Simard JM, Jacobson S, Kimberly WT. Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. The Lancet Neurology 2016, 15: 1160-1169. PMID: 27567243, DOI: 10.1016/s1474-4422(16)30196-x.Peer-Reviewed Original ResearchConceptsPlacebo-controlled phase 2 trialIntravenous glyburideLarge hemispheric infarctionPhase 2 trialGlyburide groupHemispheric infarctionDecompressive craniectomyPlacebo groupBrain swellingModified Rankin Scale scoreProtocol study populationWeb-based randomisationComposite primary outcomePrimary efficacy outcomeSerious adverse eventsProportion of patientsRankin Scale scoreBolus intravenous injectionLarge hemispheric strokePotential clinical benefitEfficacy outcomesStudy drugAdverse eventsCardiac eventsCerebral edema
2013
Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients
Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ, Sheth KN. Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients. Neurocritical Care 2013, 20: 193-201. PMID: 24072459, PMCID: PMC5198519, DOI: 10.1007/s12028-013-9917-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkersBrain EdemaBrain IschemiaCase-Control StudiesClinical Trials as TopicCohort StudiesDouble-Blind MethodFemaleGlyburideHumansHypoglycemic AgentsMagnetic Resonance ImagingMaleMatrix Metalloproteinase 9Middle AgedPilot ProjectsRandom AllocationRetrospective StudiesStrokeTreatment OutcomeConceptsVasogenic edemaIschemic strokeStroke patientsMagnetic resonance imagesMatrix metalloproteinase-9 plasma levelsSerial brain magnetic resonance imagesTransient receptor potential cation channelM member 4Secondary neurological deteriorationPlacebo-controlled trialMMP-9 levelsLarge hemispheric strokeBrain magnetic resonance imagesPreclinical rodent modelsSulfonylurea receptor 1Case-control designBrain swellingCerebral edemaNeurological deteriorationHuman strokeSerious complicationsGlyburide treatmentHemispheric strokeBlood biomarkersBlood markers