2002
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 2002, 415: 793-798. PMID: 11823786, DOI: 10.1038/nature715.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCations, DivalentCentral Nervous SystemCloning, MolecularElectrophysiologyGlutamic AcidGlycineImmunohistochemistryIn Situ HybridizationIon TransportMagnesiumMolecular Sequence DataNeuronsN-MethylaspartateOocytesProtein SubunitsRatsReceptors, GlycineReceptors, N-Methyl-D-AspartateRNA, MessengerSequence HomologySerineSubstrate SpecificityXenopus laevisConceptsExcitatory glycine receptorsGlycine receptorsN-methyl-D-aspartate (NMDA) subtypeD-serineCentral nervous systemNMDA receptor subunitsImpermeable cation channelsVoltage-dependent inhibitionBursts of firingMK-801Inhibitory neurotransmitterMotor neuronsGlutamate receptorsCerebrocortical neuronsCompetitive antagonistNervous systemDual agonistsNMDARNMDAR familyReceptor subunitsNeuronal developmentPathological processesCation channelsReceptorsNR3A
1995
Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family
Ciabarra A, Sullivan J, Gahn L, Pecht G, Heinemann S, Sevarino K. Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. Journal Of Neuroscience 1995, 15: 6498-6508. PMID: 7472412, PMCID: PMC6577996, DOI: 10.1523/jneurosci.15-10-06498.1995.Peer-Reviewed Original ResearchConceptsAgonist-activated currentsGlutamate receptor subunitsIonotropic glutamate receptor familyGlutamate receptor familyReceptor subunitsReceptor familyPostnatal day 1First postnatal weekNMDA receptor subunitsFunctional NMDA receptorsIonotropic glutamate receptorsSpinal cordCA1 fieldHeteromeric configurationsNMDA receptorsGlutamate receptorsPostnatal weekNMDA subunitsDay 1Functional expression studiesNeuronal signalingPrecise roleReceptorsTranscript levelsXenopus oocytes
1993
Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line.
Nillni E, Sevarino K, Jackson I. Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line. Endocrinology 1993, 132: 1260-70. PMID: 8440187, DOI: 10.1210/endo.132.3.8440187.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlotting, WesternElectrophoresis, Polyacrylamide GelKineticsMiceModels, GeneticMolecular Sequence DataMolecular WeightPeptide FragmentsPituitary NeoplasmsProtein PrecursorsProtein Processing, Post-TranslationalPyrrolidonecarboxylic AcidThyrotropin-Releasing HormoneTransfectionTrypsinTumor Cells, Cultured
1989
Thyrotropin-releasing hormone (TRH) precursor processing Characterization of mature TRH and non-TRH peptides synthesized by transfected mammalian cells*
Sevarino K, Goodman R, Spiess J, Jackson I, Wu P. Thyrotropin-releasing hormone (TRH) precursor processing Characterization of mature TRH and non-TRH peptides synthesized by transfected mammalian cells*. Journal Of Biological Chemistry 1989, 264: 21529-21535. PMID: 2513321, DOI: 10.1016/s0021-9258(20)88217-9.Peer-Reviewed Original ResearchCharacterization and Expression of the Gene‐Encoding Rat Thyrotropin‐Releasing Hormone (TRH)
LEE S, SEVARINO K, ROOS B, GOODMAN R. Characterization and Expression of the Gene‐Encoding Rat Thyrotropin‐Releasing Hormone (TRH). Annals Of The New York Academy Of Sciences 1989, 553: 14-28. PMID: 2497670, DOI: 10.1111/j.1749-6632.1989.tb54475.x.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernBlotting, SouthernBrainCloning, MolecularDNAEnhancer Elements, GeneticGenesMolecular Sequence DataOrgan SpecificityPromoter Regions, GeneticProtein PrecursorsRatsRecombinant Fusion ProteinsRestriction MappingRNA, MessengerThyrotropin-Releasing HormoneTransfection