2017
Mecamylamine treatment for alcohol dependence: a randomized controlled trial
Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH. Mecamylamine treatment for alcohol dependence: a randomized controlled trial. Addiction 2017, 113: 6-14. PMID: 28710873, PMCID: PMC5725262, DOI: 10.1111/add.13943.Peer-Reviewed Original ResearchConceptsHeavy drinking daysDrinking daysAlcohol use disorderUse disordersAlcohol consumptionAlcohol dependenceDouble-blind clinical trialNicotinic acetylcholine receptor antagonistWeeks of treatmentAcetylcholine receptor antagonistCurrent alcohol dependenceSignificant differencesTreatment-seeking smokersMecamylamine treatmentPlacebo groupMonth 3Primary outcomeSmoking statusNicotine withdrawalReceptor antagonistNovel pharmacotherapiesClinical trialsManagement therapyMecamylamineTreatment groups
2015
Concurrent Alcohol and Tobacco Treatment: Effect on Daily Process Measures of Alcohol Relapse Risk
Cooney NL, Litt MD, Sevarino KA, Levy L, Kranitz LS, Sackler H, Cooney JL. Concurrent Alcohol and Tobacco Treatment: Effect on Daily Process Measures of Alcohol Relapse Risk. Journal Of Consulting And Clinical Psychology 2015, 83: 346-358. PMID: 25622198, PMCID: PMC4380705, DOI: 10.1037/a0038633.Peer-Reviewed Original ResearchConceptsSmoking cessation interventionSmoking treatmentCessation interventionsSmoking abstinenceProcess measuresAlcohol treatmentOutpatient alcohol treatment programAlcohol-dependent smokersDaily smoking abstinenceAlcohol relapse riskOutpatient alcohol treatmentLow alcohol consumptionAlcohol treatment programsDependent smokersRelapse riskAlcohol abstinenceWaiting listInteractive voice response systemSmoking outcomesAlcohol consumptionCSC participantsVoice response systemIVR assessmentsTreatment programDaily assessment
2009
Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum
Cooney NL, Cooney JL, Perry BL, Carbone M, Cohen EH, Steinberg HR, Pilkey DT, Sevarino K, Oncken CA, Litt MD. Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum. Addiction 2009, 104: 1588-1596. PMID: 19549054, PMCID: PMC2753831, DOI: 10.1111/j.1360-0443.2009.02624.x.Peer-Reviewed Original ResearchConceptsActive nicotine patchNicotine patchPlacebo gumNicotine gumSmoking cessationDouble-blind placebo-controlled clinical trialAlcohol treatmentPlacebo-controlled clinical trialBetter smoking outcomesCombination nicotine patchTransdermal nicotine patchDouble-blind conditionsSubstance abuse clinicsMonthly booster sessionsCombination nicotine replacementNicotine replacementCessation treatmentTobacco smokersLarge trialsCombination therapyMore cigarettesMedication conditionActive gumClinical trialsBooster sessions
2005
Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients
Oliveto A, Poling J, Sevarino K, Gonsai K, McCance-Katz E, Stine S, Kosten T. Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients. Drug And Alcohol Dependence 2005, 79: 157-165. PMID: 16002025, DOI: 10.1016/j.drugalcdep.2005.01.007.Peer-Reviewed Original ResearchConceptsHC groupOpioid useContingency management proceduresCocaine useEfficacy of DoseOverall opioid useOpioid withdrawal symptomsHigh-dose groupLow-dose groupLY groupDrug-free urineCocaine-dependent patientsCocaine-dependent participantsBaseline characteristicsMaintenance doseWithdrawal symptomsClinical trialsCocaine abstinenceOpioidsLAAMUrine samplesHY groupAbstinenceDoseUrine
2003
Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients
Kosten T, Oliveto A, Feingold A, Poling J, Sevarino K, McCance-Katz E, Stine S, Gonzalez G, Gonsai K. Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients. Drug And Alcohol Dependence 2003, 70: 315-325. PMID: 12757969, DOI: 10.1016/s0376-8716(03)00032-2.Peer-Reviewed Original ResearchConceptsCocaine-free urinesContingency managementCocaine useOpioid withdrawal symptomsUrine toxicology resultsDrug-free urineMethadone treatmentPoor prognosisWithdrawal symptomsMethadone maintenancePlasma levelsDependent patientsToxicology resultsTreatment groupsCell trialsCocaine abuseBuprenorphineDesipraminePatientsCocaine abusersOpiatesSymptom levelsUrineAdditive effectCocaine