2000
Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development
SEVARINO K, OLIVETO A, KOSTEN T. Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development. Annals Of The New York Academy Of Sciences 2000, 909: 51-87. PMID: 10911924, DOI: 10.1111/j.1749-6632.2000.tb06676.x.Peer-Reviewed Original ResearchConceptsOpiate withdrawalLocus coeruleus noradrenergic neuronsWorldwide public health issueTreatment developmentNeurobiological adaptationsCerebral perfusion abnormalitiesTrials of antidepressantsPublic health issueNew treatment developmentCocaine vaccineAntagonist therapyNoradrenergic neuronsHeroin effectsChronic usePerfusion abnormalitiesSerotonin neurotransmissionOpiate dependenceClinical experienceOpiate maintenanceCocaine dependenceBehavioral treatmentOpiate addictionIllicit substancesHealth issuesPsychostimulants
1996
Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal
Gahn L, Sevarino K. Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal. Neuropeptides 1996, 30: 207-212. PMID: 8819143, DOI: 10.1016/s0143-4179(96)90065-7.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneVentrolateral central grayCentral grayOpiate withdrawalMorphine withdrawalAcute naltrexone treatmentPrecipitation of withdrawalHormone mRNAChronic morphineNaltrexone treatmentSystemic administrationOpiate dependencePhysical symptomsVivo evidenceWithdrawalMorphineSignificant increaseRatsSitu hybridizationMRNA