2009
Naltrexone for Initiation and Maintenance of Opiate Abstinence
Sevarino K, Kosten T. Naltrexone for Initiation and Maintenance of Opiate Abstinence. Contemporary Neuroscience 2009, 227-245. DOI: 10.1007/978-1-59745-197-0_12.Peer-Reviewed Original ResearchPartial opioid agonist buprenorphineDistinct pharmacological classesOpiate agonist methadoneRole of naltrexoneOpioid antagonist naltrexoneAntagonist naltrexoneOpiate dependencePharmacological classesOpiate abstinenceAbstinent statePhysical dependenceLong-term maintenanceNaltrexoneOpiatesBuprenorphinePharmacotherapyMethadoneAbstinence
2002
Ketoconazole increases cocaine and opioid use in methadone maintained patients
Kosten T, Oliveto A, Sevarino K, Gonsai K, Feingold A. Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug And Alcohol Dependence 2002, 66: 173-180. PMID: 11906804, DOI: 10.1016/s0376-8716(01)00198-3.Peer-Reviewed Original ResearchConceptsCortisol synthesis inhibitorOpioid usePlacebo treatmentCocaine useDouble-blind trialMorning cortisol levelsStress-induced reinstatementCocaine-related behaviorsSynthesis inhibitorSubstance abuse problemsMethadone treatmentWithdrawal symptomsKetoconazole treatmentPharmacological adrenalectomyClinical trialsBlind trialSide effectsCocaine abuseCortisol levelsMethadoneNormal valuesPatientsSubjective effectsKetoconazoleTreatment implications