1996
Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal
Gahn L, Sevarino K. Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal. Neuropeptides 1996, 30: 207-212. PMID: 8819143, DOI: 10.1016/s0143-4179(96)90065-7.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneVentrolateral central grayCentral grayOpiate withdrawalMorphine withdrawalAcute naltrexone treatmentPrecipitation of withdrawalHormone mRNAChronic morphineNaltrexone treatmentSystemic administrationOpiate dependencePhysical symptomsVivo evidenceWithdrawalMorphineSignificant increaseRatsSitu hybridizationMRNA
1993
Cocaine Regulation of Brain Preprothyrotropin‐Releasing Hormone mRNA
Sevarino K, Primus R. Cocaine Regulation of Brain Preprothyrotropin‐Releasing Hormone mRNA. Journal Of Neurochemistry 1993, 60: 1151-1154. PMID: 8436966, DOI: 10.1111/j.1471-4159.1993.tb03267.x.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneCocaine treatmentNucleus accumbensCocaine actionSolution hybridization RNase protectionMRNA levelsRat brain regionsChronic cocaine treatmentAcute cocaine treatmentPreclinical evidenceExtrahypothalamic regionsCocaine withdrawalMin postinjectionH postinjectionPrepro-TRHBrain regionsCocaine regulationCocaine reinforcementAmygdalaThalamusTRH precursorHippocampusHormone mRNASignificant decreaseRNase protection