2024
Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers
Jacokes Z, Adoremos I, Hussain A, Newman B, Pelphrey K, Van Horn J. Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers. 2024, 614-630. DOI: 10.1142/9789819807024_0044.Peer-Reviewed Original ResearchAutism spectrum disorderNeural basisDevelopmental disabilitiesCognitive traitsDiagnostic disparitiesSpectrum disorderNeuroimaging techniquesASD biomarkersSex differencesSocial functioningASD researchEffects of gene expressionNeuronal microstructureTailored interventionsBiological influencesGenetic interactionsGene expressionPhenotypic heterogeneityAutismCognitionPrincipal component analysisEarly‐ and Late‐Stage Auditory Processing of Speech Versus Non‐Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study
Edgar E, McGuire K, Pelphrey K, Ventola P, van Noordt S, Crowley M. Early‐ and Late‐Stage Auditory Processing of Speech Versus Non‐Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study. Developmental Psychobiology 2024, 66: e22552. PMID: 39508446, DOI: 10.1002/dev.22552.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNon-speech soundsSpeech soundsTD childrenSpectrum disorderCortical activityResponses to speech soundsProcessing stagesSensitivity to speechAtypical auditory processingTheta phase coherenceAuditory speech processingP3a amplitudeAuditory speechIntra-individual variabilityDevelopment of cortical networksASD childrenCortical networksSpeech processingAuditory processingElectroencephalography sessionLanguage processingCortical responsesAutismSpeechDisentangling negative and positive symptoms in schizophrenia and autism spectrum disorder
Corbera S, Wexler B, Bell M, Pittman B, Pelphrey K, Pearlson G, Assaf M. Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder. Schizophrenia Research 2024, 271: 1-8. PMID: 39002525, PMCID: PMC11384336, DOI: 10.1016/j.schres.2024.07.002.Peer-Reviewed Original ResearchAutism spectrum disorderPositive and Negative Syndrome ScaleAutism Diagnostic Observation Schedule-GenericExperiential negative symptomsPositive symptomsNegative symptomsExploratory factor analysisSpectrum disorderNegative Syndrome ScaleTarget negative symptomsSyndrome ScaleDiscriminant function analysisSZ relativesAssociated with quality of lifeSchizophreniaSocial skillsSocial functioningDiagnostic classificationAutismFactor analysisAssociated with qualityPredictor of diagnosisSymptomsDisordersQuality of lifeA common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder
Arutiunian V, Santhosh M, Neuhaus E, Sullivan C, Bernier R, Bookheimer S, Dapretto M, Geschwind D, Jack A, McPartland J, Van Horn J, Pelphrey K, Gupta A, Webb S, Network T. A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder. Autism Research 2024 PMID: 38984666, DOI: 10.1002/aur.3193.Peer-Reviewed Original ResearchAutism spectrum disorderLanguage skillsCommunication abilitySpectrum disorderStructural language abilityStructural language skillsLow language skillsCommunication skillsMeasures of languageContactin-associated protein-like 2 geneYouth aged 7Verbal communication skillsCELF-4G allele homozygotesLanguage abilityLanguage variablesNon-verbal individualsVerbal youthLanguageNeurexin familyVineland-IICandidate genesGenomic DNAGenetic mechanismsGenetic variantsTime is of the essence: Age at autism diagnosis, sex assigned at birth, and psychopathology
Smith J, McQuaid G, Wallace G, Neuhaus E, Lopez A, Ratto A, Jack A, Khuu A, Webb S, Verbalis A, Pelphrey K, Kenworthy L. Time is of the essence: Age at autism diagnosis, sex assigned at birth, and psychopathology. Autism 2024, 28: 2909-2922. PMID: 38725306, PMCID: PMC11496012, DOI: 10.1177/13623613241249878.Peer-Reviewed Original ResearchSymptoms of anxiety/depressionDepressive symptomsIdentification of autismCommunity-based sampleAnxious/depressed symptomsClinic-based sampleInclusionary criteriaAutism diagnosisAutismClinic-basedMental healthSymptomsAnxiety/depressionSex-basedPsychopathologyAnxietySexIndividualsMaleAge-based disparitiesFemalesBoys/menDiagnostic ageGirls/womenResearchThe relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives
Arutiunian V, Santhosh M, Neuhaus E, Borland H, Tompkins C, Bernier R, Bookheimer S, Dapretto M, Gupta A, Jack A, Jeste S, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S. The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives. Molecular Autism 2024, 15: 19. PMID: 38711098, PMCID: PMC11075235, DOI: 10.1186/s13229-024-00598-1.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderElevated gamma powerLow language skillsGamma powerResponses to speech stimuliLanguage skillsLanguage functionFirst-degree relativesSpectrum disorderClinical Evaluation of Language FundamentalsCo-occurring language impairmentSpeech stimuliCortical gamma-band oscillationsHigh gamma powerSex-balanced sampleGamma-band oscillationsSample of participantsNonverbal IQLanguage impairmentASD participantsTD controlsNeural profilesAutism phenotypeTD groupLanguage FundamentalsConduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
Newman B, Jacokes Z, Venkadesh S, Webb S, Kleinhans N, McPartland J, Druzgal T, Pelphrey K, Van Horn J, Consortium F. Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder. PLOS ONE 2024, 19: e0301964. PMID: 38630783, PMCID: PMC11023574, DOI: 10.1371/journal.pone.0301964.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial Communication QuestionnaireSpectrum disorderCharacteristics of autism spectrum disorderAssociated with higher scoresEtiology of autism spectrum disorderMagnetic resonance imagingNeurotypical participantsWhite matter skeletonCommunication QuestionnaireBehavioral functionsFunctional connectivityT1w/T2w ratioNeuronal differencesStructural connectivityAdolescent participantsHigher scoresConduction velocityCortexExtracellular waterDisordersResonance imagingDiffusion MRI techniquesGender, assigned sex at birth, and gender diversity: Windows into diagnostic timing disparities in autism
McQuaid G, Ratto A, Jack A, Khuu A, Smith J, Duane S, Clawson A, Lee N, Verbalis A, Pelphrey K, Kenworthy L, Wallace G, Strang J. Gender, assigned sex at birth, and gender diversity: Windows into diagnostic timing disparities in autism. Autism 2024, 28: 2806-2820. PMID: 38587289, PMCID: PMC11458814, DOI: 10.1177/13623613241243117.Peer-Reviewed Original ResearchGender identityGender diversityGender diverse peopleGender diverse populationsAutism diagnosisReduce mental health risksFemale sexMental health problemsCisgender peopleClinic-based sampleMental health risksAutistic peopleAssociated with riskAutism diagnosis in adulthoodAssigned sexClinic-basedDiagnosis in adulthoodHealth problemsGenderAutistic sampleFemale genderIdentityAutismPeopleMale gender
2009
The Neural Development of an Abstract Concept of Number
Cantlon JF, Libertus ME, Pinel P, Dehaene S, Brannon EM, Pelphrey KA. The Neural Development of an Abstract Concept of Number. Journal Of Cognitive Neuroscience 2009, 21: 2217-2229. PMID: 19016605, PMCID: PMC2745480, DOI: 10.1162/jocn.2008.21159.Peer-Reviewed Original ResearchConceptsBrain mechanismsYears of lifeFunctional magnetic resonance imagingMagnetic resonance imagingInferior frontal cortexCore neural systemsFrontal cortexParietal cortexResonance imagingBrain regionsPrimate neurophysiologyDifferent notation systemsYoung childrenNeural developmentAdultsLiterate adultsCortexChildrenNumerical tasksNeural systemsAbstract conceptsAdditional supportAdult recruitsGreater degreeNumerical representationBrain Regions for Perceiving and Reasoning About Other People in School‐Aged Children
Saxe RR, Whitfield‐Gabrieli S, Scholz J, Pelphrey KA. Brain Regions for Perceiving and Reasoning About Other People in School‐Aged Children. Child Development 2009, 80: 1197-1209. PMID: 19630902, DOI: 10.1111/j.1467-8624.2009.01325.x.Peer-Reviewed Original ResearchConceptsTemporo-parietal junctionPosterior superior temporal sulcusRight temporo-parietal junctionSuperior temporal sulcusMedial prefrontal cortexSchool-Aged ChildrenBiological motionTemporal sulcusCharacters' thoughtsPrefrontal cortexPeople's thoughtsMental factsPosterior cingulateBrain regionsCortical regionsYoung childrenOlder childrenSame storyThoughtPhysical contextResponse selectivityChildrenPeoplePerceivingCingulateAction Understanding in the Superior Temporal Sulcus Region
Vander Wyk BC, Hudac CM, Carter EJ, Sobel DM, Pelphrey KA. Action Understanding in the Superior Temporal Sulcus Region. Psychological Science 2009, 20: 771-777. PMID: 19422619, PMCID: PMC2849148, DOI: 10.1111/j.1467-9280.2009.02359.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrain MappingChoice BehaviorColor PerceptionConcept FormationDominance, CerebralEmotionsFemaleHumansImage Processing, Computer-AssistedIntentionMagnetic Resonance ImagingMaleMotion PerceptionOxygenPattern Recognition, VisualPersonal Construct TheoryPsychomotor PerformanceSocial PerceptionTemporal LobeYoung AdultConceptsSuperior temporal sulcus regionEmotional expressionSTS regionPosterior superior temporal sulcus regionSulcus regionFunctional magnetic resonancePosterior STSAction understandingBiological motionEmotional contextNegative emotionsNegative regardPositive regardPerson's motionSocial actCongruentParticipantsIntentionEmotionsObjectsCongruencyPerceptionActionActressMagnetic resonance
2008
Developmental changes in category-specific brain responses to numbers and letters in a working memory task
Libertus ME, Brannon EM, Pelphrey KA. Developmental changes in category-specific brain responses to numbers and letters in a working memory task. NeuroImage 2008, 44: 1404-1414. PMID: 19027079, PMCID: PMC2659412, DOI: 10.1016/j.neuroimage.2008.10.027.Peer-Reviewed Original ResearchConceptsCategory-specific activationFunctional magnetic resonance imagingWM taskMemory taskBehavioral performanceBrain activityBrain regionsCategory-specific dissociationsLateral fusiform gyrusOccipital-temporal cortexBrain activity patternsEight-year-old childrenFace stimuliWM conditionCognitive abilitiesSemantic processingLanguage abilityLetter conditionFMRI resultsFusiform gyrusAbstract processingIntraparietal sulcusBrain responsesDigit conditionLinguistic abilitiesPhysiology and functioning: Parents’ vagal tone, emotion socialization, and children’s emotion knowledge
Perlman SB, Camras LA, Pelphrey KA. Physiology and functioning: Parents’ vagal tone, emotion socialization, and children’s emotion knowledge. Journal Of Experimental Child Psychology 2008, 100: 308-315. PMID: 18486947, DOI: 10.1016/j.jecp.2008.03.007.Peer-Reviewed Original ResearchConceptsChildren's emotion knowledgeEmotion knowledgeSocialization behaviorsEmotion socialization behaviorsEmotional facial expressionsFamily emotional expressivenessVagal toneEmotion socializationEmotional expressivenessEmotional developmentCardiac vagal toneFacial expressionsSocialization variablesLaboratory sessionsParentsPhysiological regulationToneChildrenFunctioningBehaviorSocializationSessionsExpressivenessKnowledgeFindings